在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SEMA4A Antibody

  • 中文名稱:
    SEMA4A兔多克隆抗體
  • 貨號:
    CSB-PA954171
  • 規格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA954171(SEMA4A Antibody) at dilution 1/45, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    CORD10 antibody; RP11 54H19 2 antibody; RP35 antibody; SEM4A_HUMAN antibody; Sema B antibody; Sema domain immunoglobulin domain Ig transmembrane domain TM and short cytoplasmic domain 4A antibody; Sema domain immunoglobulin domain Ig transmembrane domain TM and short cytoplasmic domain semaphorin 4A antibody; Sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) antibody; Sema4a antibody; SEMAB antibody; Semaphorin 4A precursor antibody; Semaphorin B antibody; Semaphorin-4A antibody; Semaphorin-B antibody; SEMB antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Fusion protein of Human SEMA4A
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:10000
    IHC 1:30-1:150
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Cell surface receptor for PLXNB1, PLXNB2, PLXNB3 and PLXND1 that plays an important role in cell-cell signaling. Regulates glutamatergic and GABAergic synapse development. Promotes the development of inhibitory synapses in a PLXNB1-dependent manner and promotes the development of excitatory synapses in a PLXNB2-dependent manner. Plays a role in priming antigen-specific T-cells, promotes differentiation of Th1 T-helper cells, and thereby contributes to adaptive immunity. Promotes phosphorylation of TIMD2. Inhibits angiogenesis. Promotes axon growth cone collapse. Inhibits axonal extension by providing local signals to specify territories inaccessible for growing axons.
  • 基因功能參考文獻:
    1. Human oligodendrocytes undergo apoptosis when exposed to Sema4A and take up H-ferritin for meeting iron requirements and that these functions are mediated via the Tim-1 receptor. H-ferritin can block Sema4A-mediated cytotoxicity. Sema4A is detectable in the CSF of multiple sclerosis patients and HIV-seropositive persons and can induce oligodendrocyte cell death. PMID: 29457657
    2. Advanced peri-implantitis lesions showed higher levels of gene expression for Sem3A and Sem4D and lower levels of Sem4A in comparison to tissues obtained from a healthy dental implant. PMID: 29763494
    3. Here we show three families with retinal degeneration in which unaffected family members are either homozygous or heterozygous for the variant. The p.R713Q variant in SEMA4A is insufficient to cause either autosomal recessive or autosomal dominant retinitis pigmentosa and is unlikely to be pathogenic. PMID: 28805479
    4. ILT-4 is a receptor for hSEMA4A)on activated CD4(+) T cells. hSEMA4A is highly expressed in human asthmatic lung tissue. PMID: 29467366
    5. Suggest a role for Plexin-B1 as a ligand and Sema4A as a receptor and characterize a reverse signaling pathway downstream of Sema4A regulating cell migration via Scrib. PMID: 28007914
    6. SEMA 4A confers doxorubicin resistance on hepatocellular carcinoma by inducing epithelialemesenchymal transition. PMID: 27697528
    7. In this review, we summarized the current findings on neuroimmune Sema4A and Sema4D molecules in chronic inflammation underlying many diseases and discussed their positive or negative impacts on the implicated molecular and cellular processes PMID: 27554682
    8. Sema4A activated the Akt pathway via Plexin D1 receptor in lung fibroblasts.Lung fibroblasts show elevated levels of Sema4A expression in systemic sclerosis patients. PMID: 26648031
    9. Data suggest that increased expression of semaphorin 4A (Sema4A) is required to promote inflammation of rheumatoid arthritis (RA). PMID: 26303122
    10. Germline variants in SEMA4A predispose to familial colorectal cancer type X. PMID: 25307848
    11. PACAP released from retinal neural cells (photoreceptors or optic nerve cells) may regulate Sema4A expression in retinal pigment epithelial cells and thereby contribute to the maintenance of retinal structure and function. PMID: 25515530
    12. These results indicate the importance of the Sema4A protein conformation in human and mouse retina homeostasis. PMID: 23360997
    13. Sema4A plays an inhibitory role in T helper (Th)2-type allergic diseases, such as allergic asthma, in a fraction of Sema4a-deficient transgenic mice. PMID: 23007237
    14. mutations in SEMA4A may cause susceptibility to light exposure, oxidative stress, and ER stress, which may be involved in the progression and pathology of RP. PMID: 22956603
    15. Dendritic cell-derived SEM4A is not only critical for T helper type (Th)1 cells but also for Th17 cell differentiation, and multiple sclerosis patients with high Sema4A levels exhibit Th17 cell skewing. PMID: 22491253
    16. Mutations within the SEMA4A gene cause various retinal degnerative diseases. PMID: 16199541

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Retinitis pigmentosa 35 (RP35); Cone-rod dystrophy 10 (CORD10)
  • 亞細胞定位:
    Cell membrane; Single-pass type I membrane protein.
  • 蛋白家族:
    Semaphorin family
  • 數據庫鏈接:

    HGNC: 10729

    OMIM: 607292

    KEGG: hsa:64218

    STRING: 9606.ENSP00000347117

    UniGene: Hs.408846



主站蜘蛛池模板: 国产成熟妇女性视频电影| 丁香啪啪综合成人亚洲| 婷婷四房播播| 成年女人免费v片| a毛片免费全部播放自慰| 韩国精品视频一区二区在线播放 | 国产在线一区二区av视频| 欧美国产精品久久久乱码| 四虎成人精品一区二区免费网站| 男女后式激烈动态图片| 日本乱偷互换人妻中文字幕| 国产强奷在线播放免费| 亚欧av无码乱码在线观看性色| 少妇与大狼拘作爱性a| 久久久噜噜噜久噜久久| 色欲来吧来吧天天综合网| 男女无遮挡xx00动态图120秒| 狠狠色狠狠色综合日日不卡| 国产在线精品无码不卡手机免费 | 热re99久久精品国产99热| 成在人线av无码免费| 亚洲337少妇裸体艺术| 五月婷婷久久草| 欧美日韩亚洲国内综合网| 无码任你躁久久久久久久| 日日婷婷夜日日天干| 亚洲熟妇无码av不卡在线播放 | 久久99国产综合精品女同| 国产99久久精品一区二区| 亚洲一区精品无码| 无码写真精品永久福利在线| 国产成人精品亚洲精品| 性欧美熟妇videofreesex| 精品无码av无码专区| 国产内射xxxxx在线| 国产99视频精品免费视看6| 久久无码字幕中文久久无码| 少妇精品导航| 奇米影视7777狠狠狠狠色| а天堂中文在线官网在线| 尤物视频在线观看|