在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ELP3 Antibody, HRP conjugated

ELP3 Antibody, HRP conjugated

  • 中文名稱：
    ELP3兔多克隆抗體, HRP偶聯(lián)
  • 貨號(hào)：
    CSB-PA884499LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) ELP3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    ELP3
  • 別名：
    DKFZp761L098 antibody; Elongation protein 3 homolog (S. cerevisiae) antibody; Elongation protein 3 homolog antibody; ELONGATION PROTEIN 3; S. CEREVISIAE; HOMOLOG OF antibody; elongator acetyltransferase complex subunit 3 antibody; Elongator complex protein 3 antibody; elp3 antibody; ELP3_HUMAN antibody; FLJ10422 antibody; hELP3 antibody; Hypothetical protein DKFZp761L098 antibody; Kat9 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Elongator complex protein 3 protein (1-85AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. May also act as a protein lysine acetyltransferase by mediating acetylation of target proteins; such activity is however unclear in vivo and recent evidences suggest that ELP3 primarily acts as a tRNA acetyltransferase. Involved in neurogenesis: regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation. Required for acetylation of GJA1 in the developing cerebral cortex.
  • 基因功能參考文獻(xiàn)：
    1. and CTU1/2, partner enzymes in U34 methoxycarbonylmethyl-2-thio tRNA modification, are up-regulated in human breast cancers and sustain metastasis. PMID: 27811057
    2. Promoter hypermethylation is an important mechanism of the transcriptional inactivation of ELP3 in invasive ductal breast carcinoma. PMID: 25148870
    3. Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stress. PMID: 24769394
    4. data suggest that hElp3 can regulate the transcription of HSP70 gene, and the HAT domain of hElp3 is essential for this function PMID: 22216241
    5. The results of this study uncover a novel role for Elp3 in the regulation of synaptic bouton expansion during neurogenesis that may be linked with a requirement for sleep. PMID: 20626565
    6. Elp3 promotes the acetylation of alpha-tubulin in microtubules in neurological disorders. PMID: 20036197
    7. We used hELP3 antisense oligonucl. to knock down hELP3 gene. The results showed that reduction of hELP3 mRNA and protein caused a suppression of HSP70-2 and histone H3 hypoacetylation. PMID: 17558451
    8. Allelic variants of ELP3 were associated with amyotrophic lateral sclerosis in three populations comprising 1483 people. PMID: 18996918
    9. ELP3 localises to mitochondria in HeLa cells, actin-like filaments, and actin-rich sites at the edges of spreading cells. This suggests that ELP3 and the ELONGATOR complex may play a role in mitochondrial function, actin organisation, and cell motility. PMID: 19429107

    顯示更多

    收起更多

  • 相關(guān)疾病：
    ELP3 genetic variations may be associated with an increased risk for neurodegeneration and motor neuron diseases.
  • 亞細(xì)胞定位：
    Cytoplasm. Nucleus.; [Isoform 1]: Nucleus.; [Isoform 2]: Cytoplasm. Nucleus.
  • 蛋白家族：
    ELP3 family
  • 組織特異性：
    Expressed in the cerebellum and spinal motor neurons.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 20696

    OMIM: 612722

    KEGG: hsa:55140

    STRING: 9606.ENSP00000256398

    UniGene: Hs.491336



主站蜘蛛池模板： 真实国产熟睡乱子伦视频| 亚洲色无码专线精品观看| 日本国产成人国产在线播放| 成人无码a∨电影免费| 国产精品久久久| 国产午夜精品久久久久免费视| 少妇被爽到高潮动态图| 在线天堂中文www官网| 在线看片免费人成视频影院看| 狠狠躁天天躁无码中文字幕 | 无码h肉动漫在线观看| 99视频精品全部免费 在线| 中国人妻被两个老外三p| 男人狂躁进女人下面免费视频| 人妻少妇无码精品视频区| 亚洲v国产v欧美v久久久久久| 久久亚洲人成电影网| 免费观看一区二区三区| 一本一道久久综合狠狠老| 久久久久国精品产熟女久色| 人妻少妇精品无码专区芭乐视网| 人妻精品动漫h无码中字| 亚洲久热无码av中文字幕| 男女啪啪做爰高潮无遮挡| 国产jjizz女人多水| 国产真实的和子乱拍在线观看| 国产乱妇乱子视频在播放| 国产综合有码无码视频在线| 情侣激情18内射骚话国产| 少妇太爽了在线观看| 中文成人无码精品久久久不卡| 国产午夜亚洲精品理论片不卡| 97夜夜澡人人爽人人| 久久天天躁狠狠躁夜夜网站| 亚欧欧美人成视频在线| 亚洲乱码中文字幕小综合| 无码av一区二区三区无码| 亚洲女人自熨在线视频| 久久精品国产只有精品96| 无码人妻一区二区三区线| 人妻丝袜中文无码av影音先锋专区 |