在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. ELP3 Antibody

ELP3 Antibody

  • 中文名稱：
    ELP3兔多克隆抗體
  • 貨號：
    CSB-PA930405
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA930405(ELP3 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA930405(ELP3 Antibody) at dilution 1/15, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    ELP3
  • 別名：
    DKFZp761L098 antibody; Elongation protein 3 homolog (S. cerevisiae) antibody; Elongation protein 3 homolog antibody; ELONGATION PROTEIN 3; S. CEREVISIAE; HOMOLOG OF antibody; elongator acetyltransferase complex subunit 3 antibody; Elongator complex protein 3 antibody; elp3 antibody; ELP3_HUMAN antibody; FLJ10422 antibody; hELP3 antibody; Hypothetical protein DKFZp761L098 antibody; Kat9 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human ELP3
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:15-1:50
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Catalytic tRNA acetyltransferase subunit of the RNA polymerase II elongator complex, which is a component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. May also act as a protein lysine acetyltransferase by mediating acetylation of target proteins; such activity is however unclear in vivo and recent evidences suggest that ELP3 primarily acts as a tRNA acetyltransferase. Involved in neurogenesis: regulates the migration and branching of projection neurons in the developing cerebral cortex, through a process depending on alpha-tubulin acetylation. Required for acetylation of GJA1 in the developing cerebral cortex.
  • 基因功能參考文獻：
    1. and CTU1/2, partner enzymes in U34 methoxycarbonylmethyl-2-thio tRNA modification, are up-regulated in human breast cancers and sustain metastasis. PMID: 27811057
    2. Promoter hypermethylation is an important mechanism of the transcriptional inactivation of ELP3 in invasive ductal breast carcinoma. PMID: 25148870
    3. Regulation of G6PD acetylation by SIRT2 and KAT9 modulates NADPH homeostasis and cell survival during oxidative stress. PMID: 24769394
    4. data suggest that hElp3 can regulate the transcription of HSP70 gene, and the HAT domain of hElp3 is essential for this function PMID: 22216241
    5. The results of this study uncover a novel role for Elp3 in the regulation of synaptic bouton expansion during neurogenesis that may be linked with a requirement for sleep. PMID: 20626565
    6. Elp3 promotes the acetylation of alpha-tubulin in microtubules in neurological disorders. PMID: 20036197
    7. We used hELP3 antisense oligonucl. to knock down hELP3 gene. The results showed that reduction of hELP3 mRNA and protein caused a suppression of HSP70-2 and histone H3 hypoacetylation. PMID: 17558451
    8. Allelic variants of ELP3 were associated with amyotrophic lateral sclerosis in three populations comprising 1483 people. PMID: 18996918
    9. ELP3 localises to mitochondria in HeLa cells, actin-like filaments, and actin-rich sites at the edges of spreading cells. This suggests that ELP3 and the ELONGATOR complex may play a role in mitochondrial function, actin organisation, and cell motility. PMID: 19429107

    顯示更多

    收起更多

  • 相關疾病：
    ELP3 genetic variations may be associated with an increased risk for neurodegeneration and motor neuron diseases.
  • 亞細胞定位：
    Cytoplasm. Nucleus.; [Isoform 1]: Nucleus.; [Isoform 2]: Cytoplasm. Nucleus.
  • 蛋白家族：
    ELP3 family
  • 組織特異性：
    Expressed in the cerebellum and spinal motor neurons.
  • 數據庫鏈接：

    HGNC: 20696

    OMIM: 612722

    KEGG: hsa:55140

    STRING: 9606.ENSP00000256398

    UniGene: Hs.491336



主站蜘蛛池模板： 久久99热只有频精品8| a∨变态另类天堂无码专区| 中文字幕无码专区人妻系列| 又粗又黄又猛又爽大片免费| 精品久久人妻av中文字幕| 亚洲人成人网站色www| 男女性潮高清免费网站| 精品无码成人久久久久久| 亚洲精品成a人在线观看| 久久国产精久久精产国| 奶真大水真多小荡货av| 日本丰满少妇bbb| 国产精品一卡二卡三卡四卡| 99精品无码一区二区| 欧美综合精品久久久久成人影院 | 中文无码精品a∨在线观看不卡| 国产主播一区二区三区在线观看| 色99久久久久高潮综合影院| 人妻丰满熟妇av无码区免| 日韩 欧美 国产 一区三| 国产成人亚洲综合色婷婷秒播| 超薄丝袜足j好爽在线| 国产精品亚洲专区无码牛牛| 一区二区三区人妻无码| 亚洲婷婷综合色香五月| 国产精品高潮呻吟av久久黄| ā片在线观看免费观看| 欧美成人秋霞久久aa片| 亚洲成av人片在www| 国产精品人妻熟女男人的天堂| 久久精品国产亚洲7777| 久久se精品一区精品二区| 成人亚洲一区无码久久| 国产网红女主播精品视频| 欧美人与动人物牲交免费观看久久| 在线综合亚洲欧美网站| 成年女人看片永久免费视频| 精品国产品香蕉在线| 久久婷婷色综合一区二区| 男人a天堂手机在线版| 亚洲精品aa片在线观看国产|