在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Tescalcin (TESC)

In Stock
  • 中文名稱:
    人TESC重組蛋白
  • 貨號:
    CSB-EP023393HU
  • 規(guī)格:
    ¥1344
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 基因名:
    TESC
  • Uniprot No.:
  • 別名:
    TESC; CHP3Calcineurin B homologous protein 3; Tescalcin; TSC
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Mature Protein
  • 來源:
    E.coli
  • 分子量:
    40.6kDa
  • 表達區(qū)域:
    2-214aa
  • 氨基酸序列
    GAAHSASEEVRELEGKTGFSSDQIEQLHRRFKQLSGDQPTIRKENFNNVPDLELNPIRSKIVRAFFDNRNLRKGPSGLADEINFEDFLTIMSYFRPIDTTMDEEQVELSRKEKLRFLFHMYDSDSDGRITLEEYRNVVEELLSGNPHIEKESARSIADGAMMEAASVCMGQMEPDQVYEGITFEDFLKIWQGIDIETKMHVRFLNMETMALCH
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 6xHis-SUMO-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Functions as an integral cofactor in cell pH regulation by controlling plasma membrane-type Na(+)/H(+) exchange activity. Promotes the maturation, transport, cell surface stability and exchange activity of SLC9A1/NHE1 at the plasma membrane. Promotes the induction of hematopoietic stem cell differentiation toward megakaryocytic lineage. Essential for the coupling of ERK cascade activation with the expression of ETS family genes in megakaryocytic differentiation. Also involved in granulocytic differentiation in a ERK-dependent manner. Inhibits the phosphatase activity of calcineurin.
  • 基因功能參考文獻:
    1. This study found that the genotype of TESC at the rs7294919 locus and MDD had a significant interactive effect on the hippocampal subfield volume. PMID: 28575645
    2. High Tescalcin expression is associated with colorectal cancer. PMID: 27485112
    3. CHP3 functions as a novel negative regulator of cardiomyocyte hypertrophy via inhibition of GSK3alpha/beta phosphorylation. PMID: 25935310
    4. This study demonstrated that highly significant effects of rs7294919 of tescalcin on hippocampal gray matter volumes. PMID: 24776739
    5. a binding partner and regulator of subunit 4 of the COP9 signalosome PMID: 24659803
    6. TESC is overexpressed in colorectal cancer PMID: 24811141
    7. Loss of both N-myristoylation and calcium binding of CHP3 decreases cell surface stability of NHE1. PMID: 22984264
    8. Tescalcin is one of the key gene products that is involved in switching differentiation program in some cell types. PMID: 20060826
    9. CHP3 binds directly to the proximal juxtamembrane C-terminal region (amino acids 505-571) of rat NHE1 in the same region that binds CHP1 and CHP2. PMID: 18321853

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Cytoplasm. Membrane; Lipid-anchor. Cell membrane. Cell projection, lamellipodium. Cell projection, ruffle membrane.
  • 蛋白家族:
    Calcineurin regulatory subunit family, CHP subfamily
  • 組織特異性:
    Expressed in mature megakaryocytes and polymorphonuclear granulocytes (at protein level). Abundantly expressed in heart. Also expressed at a lower level in adult testis and salivary gland, and in the placenta.
  • 數據庫鏈接:

    HGNC: 26065

    OMIM: 611585

    KEGG: hsa:54997

    STRING: 9606.ENSP00000334785

    UniGene: Hs.525709



主站蜘蛛池模板: 午夜天堂精品久久久久| 日本不卡高字幕在线2019| 富婆如狼似虎找黑人老外| 国产尤物av尤物在线看| 青青青草国产线观| 亚洲欧美日韩中文加勒比| 亚洲2020天天堂在线观看| 99久久久国产精品消防器材| 久久久国产一区二区三区| 欧美黑人又粗又大又爽免费| 性色av免费观看| 变态 另类 欧美 大码 日韩| 国产亚洲精品第一综合不卡| 亚洲最大日夜无码中文字幕| 国产97色在线 | 日韩| 国产成人av无码精品天堂| 久草热8精品视频在线观看| 免费精品国偷自产在线2020| 亚洲影院丰满少妇中文字幕无码 | 无码熟妇人妻av在线影片免费| 情侣激情18内射骚话国产| 中文毛片无遮挡高潮免费| 性高湖久久久久久久久aaaaa| 亚洲成av人片在一线观看| 欧美综合自拍亚洲图久青草| 欧美成人aa大片| 色一情一乱一伦麻豆| 久久婷婷激情综合色综合俺也去| 曰本大码熟中文字幕| 人人爽人人添人人超| 国产做a爰片久久毛片a片| 免费大黄网站在线观| 欧美又粗又大又黄的片| 国产三级在线观看播放视频| 啦啦啦www在线观看免费视频| 亚洲人成网77777色在线播放| 亚洲婷婷六月的婷婷| 九九99无码精品视频在线观看| 亚洲国产精品久久久久久久| 亚洲精品国产精品国自产| 成年女人免费v片|