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  4. Recombinant Human Succinate dehydrogenase assembly factor 2, mitochondrial (SDHAF2)

Recombinant Human Succinate dehydrogenase assembly factor 2, mitochondrial (SDHAF2)

  • 中文名稱：
    人SDHAF2重組蛋白
  • 貨號：
    CSB-YP885749HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人SDHAF2重組蛋白
  • 貨號：
    CSB-EP885749HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人SDHAF2重組蛋白
  • 貨號：
    CSB-EP885749HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人SDHAF2重組蛋白
  • 貨號：
    CSB-BP885749HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人SDHAF2重組蛋白
  • 貨號：
    CSB-MP885749HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    SDHAF2
  • Uniprot No.：
  • 別名：
    Chromosome 11 open reading frame 79; FLJ20487; hSDH5; mitochondrial; Paraganglioma or familial glomus tumors 2; PGL2; SDH assembly factor 2; SDH5; Sdhaf2; SDHF2_HUMAN; Succinate dehydrogenase assembly factor 2, mitochondrial; Succinate dehydrogenase subunit 5
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    30-166
  • 氨基酸序列
    S FRRFYRGDSP TDSQKDMIEI PLPPWQERTD ESIETKRARL LYESRKRGML ENCILLSLFA KEHLQHMTEK QLNLYDRLIN EPSNDWDIYY WATEAKPAPE IFENEVMALL RDFAKNKNKE QRLRAPDLEY LFEKPR
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer.
  • 基因功能參考文獻：
    1. Loss of SDHAF2 gene is associated with paragangliomas. PMID: 28099933
    2. The SDHA, TMEM127, MAX, and SDHAF2 genes contribute to hereditary pheochromocytoma and paraganglioma. PMID: 28384794
    3. data show that SDHA flavination is independent of SDHAF2 in breast cancer cells, employing an alternative mechanism. PMID: 27587393
    4. FAD interacts noncovalently with SDHA in the absence of SDH5 PMID: 27296776
    5. Autosomal dominant susceptibility for Paraganglioma is modified by imprinting and mutations in the SDHAF2 gene cause Paragangliomas only when the mutation is inherited from father. PMID: 24973967
    6. Loss of heterozygosity was found in more than 50 % of the von Hippel-Lindau-associated pheochromocytomas, and was correlated with a significant decrease (p < 0.05) in both SDHAF2 and SDHD mRNA expression, which may be suggestive of a pathogenic role. PMID: 24322175
    7. New mutation found in SDHAF2 gene in pheochromocytoma/paraganglioma patients. PMID: 24712571
    8. Data indicate that SDH5 is protected from mitochondrial LON (LONM)-mediated degradation in mitochondria by its stable interaction with SDHA, a state that is dysregulated in hereditary paraganglioma 2 (PGL2). PMID: 24414418
    9. Data indicate that succinate dehydrogenase 5 (SDH5) functions as a critical protein in regulating epithelial-mesenchymal transition (EMT) by modulating the glycogen synthase kinase (GSK)-3beta-beta-catenin signaling pathway. PMID: 23983127
    10. Studies indicate that mutations in the mitochondrial complex II structural subunit genes SDHB, SDHC and SDHD and the regulatory subunit gene SDHAF2 in many paraganglioma families. PMID: 23291190
    11. Studies indicate that an array of tumor syndromes caused by complex II-associated mutations in genes SDHA, SDHB, SDHC, SDHD, SDHAF1 and SDHAF2 have been identified over a decade. PMID: 23174333
    12. Studies indicate that the flavinylation factor Sdh5 (SDHAF2) provided insight into the possible mechanism associated with Sdh1 (SDHA) flavinylation. PMID: 23380393
    13. We established the SDHAF2 mutation status of PGL2 family members PMID: 21224366
    14. Somatic mutations of the SDHAF2 tumor suppressor gene are unlikely to frequently contribute to parathyroid tumor development in sporadic primary hyperparathyroidism. PMID: 20972721
    15. germline loss-of-function mutations in the SDH5 gene segregate with disease in a family with hereditary paraganglioma PMID: 19628817

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  • 相關疾病：
    Paragangliomas 2 (PGL2)
  • 亞細胞定位：
    Mitochondrion matrix.
  • 蛋白家族：
    SDHAF2 family
  • 數據庫鏈接：

    HGNC: 26034

    OMIM: 601650

    KEGG: hsa:54949

    STRING: 9606.ENSP00000301761

    UniGene: Hs.313247



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