在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

SDHAF2 Antibody, FITC conjugated

  • 中文名稱:
    SDHAF2兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA885749LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) SDHAF2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    SDHAF2
  • 別名:
    Chromosome 11 open reading frame 79 antibody; FLJ20487 antibody; hSDH5 antibody; mitochondrial antibody; Paraganglioma or familial glomus tumors 2 antibody; PGL2 antibody; SDH assembly factor 2 antibody; SDH5 antibody; Sdhaf2 antibody; SDHF2_HUMAN antibody; Succinate dehydrogenase assembly factor 2, mitochondrial antibody; Succinate dehydrogenase subunit 5 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Succinate dehydrogenase assembly factor 2, mitochondrial protein (30-166AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer.
  • 基因功能參考文獻:
    1. Loss of SDHAF2 gene is associated with paragangliomas. PMID: 28099933
    2. The SDHA, TMEM127, MAX, and SDHAF2 genes contribute to hereditary pheochromocytoma and paraganglioma. PMID: 28384794
    3. data show that SDHA flavination is independent of SDHAF2 in breast cancer cells, employing an alternative mechanism. PMID: 27587393
    4. FAD interacts noncovalently with SDHA in the absence of SDH5 PMID: 27296776
    5. Autosomal dominant susceptibility for Paraganglioma is modified by imprinting and mutations in the SDHAF2 gene cause Paragangliomas only when the mutation is inherited from father. PMID: 24973967
    6. Loss of heterozygosity was found in more than 50 % of the von Hippel-Lindau-associated pheochromocytomas, and was correlated with a significant decrease (p < 0.05) in both SDHAF2 and SDHD mRNA expression, which may be suggestive of a pathogenic role. PMID: 24322175
    7. New mutation found in SDHAF2 gene in pheochromocytoma/paraganglioma patients. PMID: 24712571
    8. Data indicate that SDH5 is protected from mitochondrial LON (LONM)-mediated degradation in mitochondria by its stable interaction with SDHA, a state that is dysregulated in hereditary paraganglioma 2 (PGL2). PMID: 24414418
    9. Data indicate that succinate dehydrogenase 5 (SDH5) functions as a critical protein in regulating epithelial-mesenchymal transition (EMT) by modulating the glycogen synthase kinase (GSK)-3beta-beta-catenin signaling pathway. PMID: 23983127
    10. Studies indicate that mutations in the mitochondrial complex II structural subunit genes SDHB, SDHC and SDHD and the regulatory subunit gene SDHAF2 in many paraganglioma families. PMID: 23291190
    11. Studies indicate that an array of tumor syndromes caused by complex II-associated mutations in genes SDHA, SDHB, SDHC, SDHD, SDHAF1 and SDHAF2 have been identified over a decade. PMID: 23174333
    12. Studies indicate that the flavinylation factor Sdh5 (SDHAF2) provided insight into the possible mechanism associated with Sdh1 (SDHA) flavinylation. PMID: 23380393
    13. We established the SDHAF2 mutation status of PGL2 family members PMID: 21224366
    14. Somatic mutations of the SDHAF2 tumor suppressor gene are unlikely to frequently contribute to parathyroid tumor development in sporadic primary hyperparathyroidism. PMID: 20972721
    15. germline loss-of-function mutations in the SDH5 gene segregate with disease in a family with hereditary paraganglioma PMID: 19628817

    顯示更多

    收起更多

  • 相關疾病:
    Paragangliomas 2 (PGL2)
  • 亞細胞定位:
    Mitochondrion matrix.
  • 蛋白家族:
    SDHAF2 family
  • 數據庫鏈接:

    HGNC: 26034

    OMIM: 601650

    KEGG: hsa:54949

    STRING: 9606.ENSP00000301761

    UniGene: Hs.313247



主站蜘蛛池模板: 好男人社区在线www| 国产在不卡免费一区二区三| 丰满少妇被猛烈进入av久久| 成人午夜福利视频| 亚洲午夜福利在线观看| 亚洲午夜免费福利视频| 国产成人亚洲日韩欧美| 亚洲成av人片在线观看下载| 国产av熟女一区二区三区| 四房播播开心五月| 越猛烈欧美xx00动态图| 又粗又黄又爽视频免费看| 久久综合九色综合久99| 亚洲日韩欧美国产高清αv| www插插插无码视频网站| 亚洲欧美另类成人综合图片| 国产av无码精品色午夜| 亚洲国产av一区二区三区| 国产精品香蕉在线的人| 久久九九有精品国产23百花影院| 国产高清在线精品一区二区三区 | 小辣椒福利视频导航| 亚洲成av人片天堂网久久| 成 人 网 站 免费 在线| 精品午夜福利1000在线观看| 欧美最猛黑人xxxx黑人猛交| 日本欧美亚洲中文在线观看| 国产网红女主播精品视频| 波多野结衣在线精品视频| 久久人人97超碰国产亚洲人| 亚洲五月综合缴情在线观看| 粗大的内捧猛烈进出在线视频| 日韩激情无码免费毛片| 久久久精品2019免费观看| 正在播放国产乱子伦最新视频| 国产成人av无码精品| 亚洲人成网站日本片| 亚洲国产美女久久久久| 亚洲亚洲人成综合网络| 亚洲女人自熨在线视频| 日本三级欧美三级人妇视频|