在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Rat Secretin receptor (Sctr)

  • 中文名稱:
    大鼠Sctr重組蛋白
  • 貨號:
    CSB-CF020865RA
  • 規格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產品詳情

  • 基因名:
  • Uniprot No.:
  • 別名:
    Sctr; Secretin receptor; SCT-R
  • 種屬:
    Rattus norvegicus (Rat)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區域:
    26-449
  • 氨基酸序列
    VGVPPRLCDVRRVLLEERAHCLQQLSKEKKGALGPETASGCEGLWDNMSCWPSSAPARTV EVQCPKFLLMLSNKNGSLFRNCTQDGWSETFPRPDLACGVNINNSFNERRHAYLLKLKVM YTVGYSSSLAMLLVALSILCSFRRLHCTRNYIHMHLFVSFILRALSNFIKDAVLFSSDDV TYCDAHKVGCKLVMIFFQYCIMANYAWLLVEGLYLHTLLAISFFSERKYLQAFVLLGWGS PAIFVALWAITRHFLENTGCWDINANASVWWVIRGPVILSILINFIFFINILRILMRKLR TQETRGSETNHYKRLAKSTLLLIPLFGIHYIVFAFSPEDAMEVQLFFELALGSFQGLVVA VLYCFLNGEVQLEVQKKWRQWHLQEFPLRPVAFNNSFSNATNGPTHSTKASTEQSRSIPR ASII
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Receptor for secretin (SCT), which is involved in different processes such as regulation of the pH of the duodenal content, food intake and water homeostasis. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Upon binding to secretin, regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO(3)) from the ductal cells of the pancreas. In addition to regulating the pH of the duodenal content, plays a central role in diet induced thermogenesis: acts as a non-sympathetic brown fat (BAT) activator mediating prandial thermogenesis, which consequentially induces satiation. Mechanistically, secretin released by the gut after a meal binds to secretin receptor (SCTR) in brown adipocytes, activating brown fat thermogenesis by stimulating lipolysis, which is sensed in the brain and promotes satiation. Also able to stimulate lipolysis in white adipocytes. Also plays an important role in cellular osmoregulation by regulating renal water reabsorption. Also plays a role in the central nervous system: required for synaptic plasticity.
  • 基因功能參考文獻:
    1. Structure and Function of Cross-class Complexes of G Protein-coupled Secretin and Angiotensin 1a Receptors. PMID: 27330080
    2. Secretin receptors are overexpressed in various endocrine tumor cells and play a proproliferative role in pheochromocytoma and adrenocortical carcinoma cells. PMID: 22692904
    3. Molecular basis of secretin docking to its intact receptor using multiple photolabile probes distributed throughout the pharmacophore. PMID: 21566140
    4. Data show that in secretin/secretin receptor binding, the alpha-helix in natural secretin was oriented approximately parallel to the amino-terminal alpha-helix of the receptor. PMID: 21388146
    5. This recepetor interacts with secretin at specific binding sites. PMID: 12403838
    6. analysis of the pattern of disulfide bonds in the functional intact secretin receptor PMID: 15664984
    7. There is a charge-charge interaction between glutamic acid residue at position 351 and amino terminus that is critical to secretin normal docking. PMID: 15731172
    8. refined model of the intact receptor was also fully consistent with the spatial approximation of the Trp(48)-Asp(49)-Asn(50) endogenous agonist segment with the third extracellular loop region that it has been shown to photolabel PMID: 17827151
    9. Model of helical bundle and loop domains of prototypic secretin receptor is consistent with endogenous agonist mechanism for class II G-protein-coupled receptor activation, where ligand binding promotes interaction of a portion of receptor amino terminus. PMID: 18467541

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 2 family
  • 組織特異性:
    In the brain, expressed in the central amygdala, hippocampus, area postrema, nucleus of the tractus solitary and cerebellum.
  • 數據庫鏈接:


主站蜘蛛池模板: 毛片免费全部播放无码| 人间精品视频在线播放| 免费无码又爽又黄又刺激网站| 国产精品亚洲专区无码唯爱网 | 中文字幕日本特黄aa毛片| 大香伊蕉在人线免费视频| 欧美日韩中文在线字幕视频| 加勒比无码一区二区三区| 人禽杂交18禁网站免费| 中文字幕中文有码在线| 18级成人毛片免费观看| 性色av无码一区二区三区人妻| 日产亚洲一区二区三区| 100禁毛片免费40分钟视频| 最大胆裸体人体牲交免费| 大肉大捧一进一出好爽视色大师| 国产精品久久久久久妇女| 免费看女人与善牲交| 久久www免费人成_看片老司机 | 亚洲狠狠婷婷综合久久蜜芽| 日本精品αv中文字幕| 精品无码成人网站久久久久久| 久久av无码精品人妻糸列| 人禽无码视频在线观看| 国产桃色无码视频在线观看| 成人黄网站高清免费视频| 国产一区二区三区免费观看在线| 亚洲毛片不卡av在线播放一区| 无码动漫性爽xo视频在线观看| 国产午夜福利伦理300| 国产日韩一区二区三免费高清| 2021国产精品一卡2卡三卡4卡| 欧美精品a∨在线观看| 影音先锋中文字幕人妻| 欧美性猛交xxxx乱大交极品| 亚洲精品久久久久久久久久久捆绑| 人妻熟女一区二区aⅴ清水理纱 | 精品无码国产自产拍在线观看| 精品久久久久久成人av| 国产清纯在线一区二区www| 日本特黄aaaaaa大片|