在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Rat Secretin receptor (Sctr), partial

Recombinant Rat Secretin receptor (Sctr), partial

  • 中文名稱：
    大鼠Sctr重組蛋白
  • 貨號：
    CSB-YP020865RA1
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    大鼠Sctr重組蛋白
  • 貨號：
    CSB-EP020865RA1
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    大鼠Sctr重組蛋白
  • 貨號：
    CSB-EP020865RA1-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大鼠Sctr重組蛋白
  • 貨號：
    CSB-BP020865RA1
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大鼠Sctr重組蛋白
  • 貨號：
    CSB-MP020865RA1
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Sctr; Secretin receptor; SCT-R
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Receptor for secretin (SCT), which is involved in different processes such as regulation of the pH of the duodenal content, food intake and water homeostasis. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. Upon binding to secretin, regulates the pH of the duodenum by (1) inhibiting the secretion of gastric acid from the parietal cells of the stomach and (2) stimulating the production of bicarbonate (NaHCO(3)) from the ductal cells of the pancreas. In addition to regulating the pH of the duodenal content, plays a central role in diet induced thermogenesis: acts as a non-sympathetic brown fat (BAT) activator mediating prandial thermogenesis, which consequentially induces satiation. Mechanistically, secretin released by the gut after a meal binds to secretin receptor (SCTR) in brown adipocytes, activating brown fat thermogenesis by stimulating lipolysis, which is sensed in the brain and promotes satiation. Also able to stimulate lipolysis in white adipocytes. Also plays an important role in cellular osmoregulation by regulating renal water reabsorption. Also plays a role in the central nervous system: required for synaptic plasticity.
  • 基因功能參考文獻：
    1. Structure and Function of Cross-class Complexes of G Protein-coupled Secretin and Angiotensin 1a Receptors. PMID: 27330080
    2. Secretin receptors are overexpressed in various endocrine tumor cells and play a proproliferative role in pheochromocytoma and adrenocortical carcinoma cells. PMID: 22692904
    3. Molecular basis of secretin docking to its intact receptor using multiple photolabile probes distributed throughout the pharmacophore. PMID: 21566140
    4. Data show that in secretin/secretin receptor binding, the alpha-helix in natural secretin was oriented approximately parallel to the amino-terminal alpha-helix of the receptor. PMID: 21388146
    5. This recepetor interacts with secretin at specific binding sites. PMID: 12403838
    6. analysis of the pattern of disulfide bonds in the functional intact secretin receptor PMID: 15664984
    7. There is a charge-charge interaction between glutamic acid residue at position 351 and amino terminus that is critical to secretin normal docking. PMID: 15731172
    8. refined model of the intact receptor was also fully consistent with the spatial approximation of the Trp(48)-Asp(49)-Asn(50) endogenous agonist segment with the third extracellular loop region that it has been shown to photolabel PMID: 17827151
    9. Model of helical bundle and loop domains of prototypic secretin receptor is consistent with endogenous agonist mechanism for class II G-protein-coupled receptor activation, where ligand binding promotes interaction of a portion of receptor amino terminus. PMID: 18467541

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 2 family
  • 組織特異性：
    In the brain, expressed in the central amygdala, hippocampus, area postrema, nucleus of the tractus solitary and cerebellum.
  • 數據庫鏈接：


主站蜘蛛池模板： 亚洲一区二区无码影院| 亚洲国产精彩中文乱码av| 在线精品视频一区二区 | 国产高清一区二区三区直播| 伊人久久大香线蕉综合中文字幕| 国偷自产视频一区二区久 | 最新亚洲精品国偷自产在线| 色欲香天天综合网站| 人人爽人人片人人片av| av片在线观看免费| 极品美女在线观看免费直播| 四虎永久地址www成人久久| 妺妺窝人体色www看人体| 欧美丰满老熟妇xxxxx性| 久久这里只精品国产免费9| 无码av喷白浆在线播放| 东北女人啪啪对白| 天堂中文在线资源| 男插女高潮一区二区| 国产1卡2卡三卡四卡精品| 肥老熟妇伦子伦456视频| 天堂а√在线官网| 久久精品亚洲乱码伦伦中文| 少妇高潮大叫好爽| 精品一区二区三区免费播放| 国产精品videossex久久发布| 久爱www人成免费网站| 欧美无人区码suv| 久久人人爽人人爽人人片| 伊人色综合久久天天人守人婷| 最大胆裸体人体牲交免费| 国产精品宾馆在线精品酒店| 成人午夜精品无码区| 亚洲无av码在线中文字幕| 午夜无码国产理论在线| 国产乱人激情h在线观看| 久久综合伊人九色综合| 成人免费无码大片a毛片18| 国产成人精品综合久久久| 野花社区在线www日本| 久久人人做人人爽人人av|