在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Rat Melanopsin (Opn4)

In Stock
  • 中文名稱:
    大鼠Opn4重組蛋白
  • 貨號:
    CSB-CF851271RA
  • 規格:
    ¥9720
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 基因名:
  • Uniprot No.:
  • 種屬:
    Rattus norvegicus (Rat)
  • 蛋白長度:
    Full Length
  • 來源:
    in vitro E.coli expression system
  • 分子量:
    53.9 kDa
  • 表達區域:
    1-474aa
  • 氨基酸序列
    MNSPSESRVPSSLTQDPSFTASPALLQGIWNSTQNISVRVQLLSVSPTTPGLQAAAWVPFPTVDVPDHAHYTLGTVILLVGLTGMLGNLTVIYTFCRNRGLRTPANMLIINLAVSDFLMSFTQAPVFFASSLYKKWLFGETGCKFYAFCGAVFGIVSMITLTAIAMDRYLVITRPLATIGMRSKRRTALVLLGVWLYALAWSLPPFFGWSAYVPEGLLTSCSWDYVTFTPLVRAYTMLLFCFVFFLPLLIIIFCYIFIFRAIRETGRACEGCGESPLRRRQWQRLQSEWKMAKVALIVILLFVLSWAPYSTVALVGFAGYSHILTPYMSSVPAVIAKASAIHNPIIYAITHPKYRAAIAQHLPCLGVLLGVSGQRSHPSLSYRSTHRSTLSSQSSDLSWISGQKRQESLGSESEVGWTDTETTAAWGAAQQASGQSFCSHDLEDGEVKAPSSPQEQKSKTPKTKRHLPSLDRRM
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Photoreceptor that binds cis-retinaldehydes. Contributes to pupillar reflex, photoentrainment and other non-image forming responses to light. May be involved in the optokinetic visual tracking response. May be involved in the regulation of retinal hyaloid vessel growth and regression.
  • 基因功能參考文獻:
    1. during retinal degeneration, the expression of melanopsin was significantly decreased, while vector-mediated overexpression of melanopsin delayed the loss of visual function in rats. PMID: 26572076
    2. Following ON injury or retrograde tracing there is a transient melanopsin downregulation that should be taken into account when assessing m(+)RGC survival. PMID: 26176868
    3. Data indicate that the phosphorylation status of melanopsin influences its functions. PMID: 25378407
    4. Early light exposure can increase the number of melanopsin immunopositive retinal ganalion cells through a process dependent on intrinsic photosensitive spiking activity. PMID: 23541830
    5. We found that light and darkness are important for regulation of melanopsin protein expression whereas input from a retinal networks regulates melanopsin mRNA expression. PMID: 23187103
    6. overexpression of mir133b decreased TH and D2 receptor expression as well as dopamine production, which finally resulted in reduced melanopsin expression PMID: 22101014
    7. Melanopsin expression defines a subset of RGCs that play a broad role in regulation of nonvisual photoreception, providing projections that contribute to circadian entrainment, negative masking, regulation of sleep-wake states, and the pupillary reflex PMID: 12904470
    8. Melanopsin, in itself, is not necessary for circadian photoreception. In fact, it appears that of the known photoreceptor systems, none, in and of itself, is necessary for circadian photoreception. PMID: 14500998
    9. During rat retinal development melanopsin is expressed at prenatal day 18 in cells of the inner neuroblast layer. and During early postnatal development a melanopsin immunoreactive dendritic network is formed in the inner plexiform layer. PMID: 15073514
    10. We investigated the effect of photoreceptor degeneration on melanopsin mRNA regulation in RCS/N-rdy rats (Royal College of Surgeons rats with a defect in the retinal dystrophy gene). PMID: 15509757
    11. Data suggest that retinal ganglion cells adapt their expression of the putative circadian photopigment melanopsin to environmental light and darkness. PMID: 16186625
    12. Regulation of melanopsin expression [review] PMID: 16687290
    13. melanopsin-containing RGCs have synaptic contact with PKC/CtBP2-containing rod bipolar cells PMID: 17652756
    14. the daily and photoperiod-dependent regulation of the melanopsin gene does not rely on a circadian oscillator but is directly illumination-dependent PMID: 18001324
    15. The PI3 K/Akt pathway was found to play a role in maintaining the survival of melanopsin-expressing retinal ganglion cells after injury. PMID: 18512147

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein. Cell projection, axon. Cell projection, dendrite. Perikaryon.
  • 蛋白家族:
    G-protein coupled receptor 1 family, Opsin subfamily
  • 組織特異性:
    Eye; expressed in a photosensitive subset of retinal ganglion cells (at protein level).
  • 數據庫鏈接:


主站蜘蛛池模板: 中国大陆高清aⅴ毛片| 久久久中日ab精品综合| 性按摩玩人妻hd中文字幕| 成人午夜视频精品一区| 爽死你欧美大白屁股在线| 亚洲乱码日产精品bd在线| 精品久久久久久中文字幕202| 激情 小说 亚洲 图片 伦| 好紧好爽好湿别拔出来视频男男| 日本中文字幕乱码aa高清电影 | 亚洲日韩av无码| 97精品久久久久中文字幕| 亚洲国产成人av片在线播放| 免费啪视频在线观看视频日本 | 人妻va精品va欧美va| 国产精品自在线拍国产电影| 精品亚洲一区二区三区在线播放| 潮喷大喷水系列无码久久精品| 中文字幕乱码免费| 亚洲国产精品无码久久久久高潮| 白丝乳交内射一二三区| 亚洲精品无码专区在线| 日本爽爽爽爽爽爽在线观看免 | 国产无套内射又大又猛又粗又爽| 久久大蕉香蕉免费| 亚洲欧洲日本精品专线| 久久成人麻豆午夜电影| 欧美成人综合久久精品| 天堂va视频一区二区| 性少妇中国内射xxxx狠干| 欧性猛交ⅹxxx乱大交| 国产免费又色又爽又黄软件| 99国精品午夜福利视频不卡 | 大j8黑人w巨大888a片| 高清免费精品国自产拍| 明星性猛交ⅹxxx乱大交| 亚洲国产成人av人片久久| 无码专区手机在线播放| 伴郎粗大的内捧猛烈进出视频观看 | 蜜臀久久99精品久久久久久小说| 国产精品久久久久9999|