在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Rat Melanopsin (Opn4)-VLPs

  • 中文名稱:
    Recombinant Rat Melanopsin (Opn4)-VLPs
  • 貨號:
    CSB-MP851271RA
  • 規(guī)格:
  • 其他:

產(chǎn)品詳情

  • 基因名:
  • Uniprot No.:
  • 別名:
    (Opsin-4)
  • 種屬:
    Rattus norvegicus (Rat)
  • 蛋白長度:
    Full Length
  • 來源:
    Mammalian cell
  • 表達區(qū)域:
    1-474aa
  • 氨基酸序列
    MNSPSESRVPSSLTQDPSFTASPALLQGIWNSTQNISVRVQLLSVSPTTPGLQAAAWVPFPTVDVPDHAHYTLGTVILLVGLTGMLGNLTVIYTFCRNRGLRTPANMLIINLAVSDFLMSFTQAPVFFASSLYKKWLFGETGCKFYAFCGAVFGIVSMITLTAIAMDRYLVITRPLATIGMRSKRRTALVLLGVWLYALAWSLPPFFGWSAYVPEGLLTSCSWDYVTFTPLVRAYTMLLFCFVFFLPLLIIIFCYIFIFRAIRETGRACEGCGESPLRRRQWQRLQSEWKMAKVALIVILLFVLSWAPYSTVALVGFAGYSHILTPYMSSVPAVIAKASAIHNPIIYAITHPKYRAAIAQHLPCLGVLLGVSGQRSHPSLSYRSTHRSTLSSQSSDLSWISGQKRQESLGSESEVGWTDTETTAAWGAAQQASGQSFCSHDLEDGEVKAPSSPQEQKSKTPKTKRHLPSLDRRM
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    C-terminal 10xHis-tagged
    If you have specified tag type, please tell us and we will check if it's possible to develop.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from PBS, 6% Trehalose, pH 7.4.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein indeionized sterile water to a concentration of 0.1-1.0 mg/mL.Aliquot for long-term storage at -80℃. Solubilize for 60 minutes at room temperature with occasional gentle mixing. Avoid vigorous shaking or vortexing.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事項:
    The VLPs are expressed from human 293 cells (HEK293).Mix the sample gently by repeatedly pipetting it up and down. Do not vortex. Repeated freezing and thawing is not recommended.Store the protein at -20℃/-80℃ upon receiving it, and ensure to avoid repeated freezing and thawing, otherwise, it will affect the protein activity. The immunization strategy should be optimized (antigen dose, regimen and adjuvant).
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    Photoreceptor that binds cis-retinaldehydes. Contributes to pupillar reflex, photoentrainment and other non-image forming responses to light. May be involved in the optokinetic visual tracking response. May be involved in the regulation of retinal hyaloid vessel growth and regression.
  • 基因功能參考文獻:
    1. during retinal degeneration, the expression of melanopsin was significantly decreased, while vector-mediated overexpression of melanopsin delayed the loss of visual function in rats. PMID: 26572076
    2. Following ON injury or retrograde tracing there is a transient melanopsin downregulation that should be taken into account when assessing m(+)RGC survival. PMID: 26176868
    3. Data indicate that the phosphorylation status of melanopsin influences its functions. PMID: 25378407
    4. Early light exposure can increase the number of melanopsin immunopositive retinal ganalion cells through a process dependent on intrinsic photosensitive spiking activity. PMID: 23541830
    5. We found that light and darkness are important for regulation of melanopsin protein expression whereas input from a retinal networks regulates melanopsin mRNA expression. PMID: 23187103
    6. overexpression of mir133b decreased TH and D2 receptor expression as well as dopamine production, which finally resulted in reduced melanopsin expression PMID: 22101014
    7. Melanopsin expression defines a subset of RGCs that play a broad role in regulation of nonvisual photoreception, providing projections that contribute to circadian entrainment, negative masking, regulation of sleep-wake states, and the pupillary reflex PMID: 12904470
    8. Melanopsin, in itself, is not necessary for circadian photoreception. In fact, it appears that of the known photoreceptor systems, none, in and of itself, is necessary for circadian photoreception. PMID: 14500998
    9. During rat retinal development melanopsin is expressed at prenatal day 18 in cells of the inner neuroblast layer. and During early postnatal development a melanopsin immunoreactive dendritic network is formed in the inner plexiform layer. PMID: 15073514
    10. We investigated the effect of photoreceptor degeneration on melanopsin mRNA regulation in RCS/N-rdy rats (Royal College of Surgeons rats with a defect in the retinal dystrophy gene). PMID: 15509757
    11. Data suggest that retinal ganglion cells adapt their expression of the putative circadian photopigment melanopsin to environmental light and darkness. PMID: 16186625
    12. Regulation of melanopsin expression [review] PMID: 16687290
    13. melanopsin-containing RGCs have synaptic contact with PKC/CtBP2-containing rod bipolar cells PMID: 17652756
    14. the daily and photoperiod-dependent regulation of the melanopsin gene does not rely on a circadian oscillator but is directly illumination-dependent PMID: 18001324
    15. The PI3 K/Akt pathway was found to play a role in maintaining the survival of melanopsin-expressing retinal ganglion cells after injury. PMID: 18512147

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein. Cell projection, axon. Cell projection, dendrite. Perikaryon.
  • 蛋白家族:
    G-protein coupled receptor 1 family, Opsin subfamily
  • 組織特異性:
    Eye; expressed in a photosensitive subset of retinal ganglion cells (at protein level).
  • 數(shù)據(jù)庫鏈接:


主站蜘蛛池模板: 好爽好黄的视频| 日本亲子乱子伦xxxx50路| 免费看国产成年无码av片| 久久久精品人妻一区二区三区蜜桃 | 国产午夜福利片| 人人爽人人爽人人片av东京热| 精品一区二区成人精品| 亚洲精品中文字幕无码蜜桃| 国产精品亚洲专区无码牛牛| 大肉大捧一进一出视频出来呀 | 青青草国产午夜精品| 国产人妻久久精品二区三区| 日韩中文无码有码免费视频| 亚洲爆乳大丰满无码专区| 风韵饥渴少妇在线观看| 亚洲欧美在线一区中文字幕| 人人人妻人人人妻人人人 | 性xxxx欧美老妇胖老太269| 亚洲婷婷开心色四房播播| 久久经精品久久精品免费观看| 久久久久成人精品无码| 成人精品一区日本无码网站| 夜精品一区二区无码a片| 天堂网www在线资源网| 亚洲国产av无码精品无广告| 国产在线高清理伦片a| 国产精品玖玖玖在线| 久久久久九九精品影院| 欧美色就是色| 亚洲精品午夜无码电影网| 华人少妇被黑人粗大的猛烈进| 国产精品毛片a∨一区二区三区| 97人洗澡从澡人人爽人人模| 男人狂躁进女人下面免费视频| 亚洲成色www久久网站| 欧美 亚洲 国产 日韩 综aⅴ| 美女扒开腿让男人桶爽app免费看| 无限看片在线版免费视频大全| 成人做爰免费视频免费看| 啪啪激情婷婷久久婷婷色五月| 男女猛烈激情xx00免费视频|