在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Rat Hepatitis A virus cellular receptor 1 homolog (Havcr1)

  • 中文名稱:
    大鼠Havcr1重組蛋白
  • 貨號:
    CSB-CF010144RA
  • 規(guī)格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產(chǎn)品詳情

  • 基因名:
  • Uniprot No.:
  • 別名:
    Havcr1; Kim1; Hepatitis A virus cellular receptor 1 homolog; HAVcr-1; Kidney injury molecule 1; KIM-1; T cell immunoglobulin and mucin domain-containing protein 1; TIMD-1; CD antigen CD365
  • 種屬:
    Rattus norvegicus (Rat)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達(dá)區(qū)域:
    22-307
  • 氨基酸序列
    YEVVKGVVGHPVTIPCTYSTRGGITTTCWGRGQCPYSSCQNILIWTNGYQVTYRSSGRYNIKGRISEGDVSLTIENSVDSDSGLYCCRVEIPGWFNDQKMTFSLEVKPEIPTSPPTRPTTTRPTTTRPTTISTRSTHVPTSTRVSTSTPTPEQTQTHKPEITTFYAHETTAEVTETPSYTPADWNGTVTSSEEAWNNHTVRIPLRKPQRNPTKGFYVGMSVAALLLLLLASTVVVTRYIIIRKKMGSLSFVAFHVSKSRALQNAAIVHPRAEDNIYIIEDRSRGAE
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標(biāo)簽:
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4. May play a role in kidney injury and repair.
  • 基因功能參考文獻(xiàn):
    1. High KIM1 expression is associated with decreased proximal tubular epithelial cell function. PMID: 29045706
    2. urinary KIM1 may be a valuable biomarker for the early diagnosis of obstructive AKI, and the use of a colloidal gold immunochromatographic strip may be a promising method for the rapid detection of urinary KIM1. PMID: 28075469
    3. Results show that in contrast to other known molecules indicating renal injury and/or repair mechanisms, the chronic renal expression of Kim-1 is strictly confined to proximal cysts. PMID: 27231899
    4. blood biomarker that specifically reflects acute and chronic kidney injury PMID: 24904085
    5. Ischemic postconditioning can attenuate the renal ischemia reperfusion injury and downregulate the expression of Kim-1. PMID: 22898836
    6. These studies are the first direct demonstration of regulation of KIM-1 in response to oxalate exposure in renal epithelial cells in vitro and in vivo. PMID: 22984472
    7. The most sensitive, noninvasive biomarkers of HCBD-induced renal toxicity in Hanover Wistar rats were urinary alpha-GST and KIM-1. PMID: 21905055
    8. The Kim1 gene is regulated in an epigenetic fashion under conditions of nephrotoxicity. PMID: 20660082
    9. Results show Kim-1 outperforms SCr, BUN and urinary NAG in multiple rat models of kidney injury. PMID: 20458318
    10. KIM-1 as a sensitive molecular marker of different levels of tubular injury PMID: 20305092
    11. Urinary Kim-1 serve as a noninvasive, rapid, sensitive, reproducible method to detect early kidney injury in pathophysiological studies and in preclinical drug development studies for risk-benefit profiling of pharmaceutical agents. PMID: 16174863
    12. These results implicate involvement of kidney injury molecule 1 (Kim-1) in the pathogenesis of proteinuria-induced renal damage/repair. Urinary Kim-1 levels may serve as a marker of proteinuria-induced renal damage. PMID: 16467126
    13. Kim-1 is associated with development of renin-angiotensin system-mediated renal damage PMID: 16896183
    14. Urinary Kim-1 and kidney Kim-1/Havcr1 expression appear to be sensitive and tissue-specific biomarkers that will improve detection of early acute kidney injury PMID: 17934191
    15. Data demonstrate that injured kidney epithelial cells assumed attributes of endogenous phagocytes, and that KIM-1 was directly responsible for phagocytosis in cultured primary rat tubule epithelial cells and also porcine and canine epithelial cell lines. PMID: 18414680
    16. on longitudinal follow-up during antiproteinuric treatment increased renal Kim-1 expression is reversible in proportion to proteinuria reduction, likely reflecting reversibility of early tubular injury PMID: 19225054
    17. Cadmium-induced increase in Kim-1 expression occurs before the onset of necrosis and at a point where there is only a modest level of apoptosis in the proximal tubule. PMID: 19371613
    18. Kim-1 is a sensitive biomarker of the early stages of Cadmium-induced proximal tubule injury. PMID: 19371616
    19. Dipsticks can provide a sensitive and accurate detection of Havcr1. PMID: 19387469
    20. Kim-1 is a promising novel marker for the early, organ specific and noninvasive detection of brain death-induced donor kidney damage. PMID: 19522876

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族:
    Immunoglobulin superfamily, TIM family
  • 組織特異性:
    Expressed at a low level in normal kidney but are increased dramatically in postischemic kidney. Expressed in proliferating bromodeoxyuridine-positive and dedifferentiated vimentin-positive epithelial cells in regenerating proximal tubules.
  • 數(shù)據(jù)庫鏈接:


主站蜘蛛池模板: 国产成人无码精品亚洲| 亚洲一区二区制服在线| 99精品国产在热久久无毒| 韩国精品视频一区二区在线播放 | 国产极品视觉盛宴| 亚洲欧美综合区丁香五月小说| 男女性潮高清免费网站| 成年片色大黄全免费网站久久高潮| 欧洲人妻丰满av无码久久不卡| 中文字幕无码人妻aaa片| 亚洲国产精品一区二区第四页 | 国产成人a无码短视频| 色偷偷色噜噜狠狠网站久久| 国产精品你懂的在线播放| 97人洗澡从澡人人爽人人模| 国产产在线精品亚洲aavv | 亚洲 小说 欧美 另类 社区| 午夜精品乱人伦小说区| 小罗莉极品一线天在线| 激情综合五月| 亚洲综合久久精品无码色欲| 纯肉无遮挡h肉动漫在线观看国产| 国产精品丝袜高跟鞋| 欧美疯狂性受xxxxx另类| 亚洲国产精品久久久久婷婷软件| 日99久9在线 | 免费| 成人性生交大免费看| 亚洲人成电影在线播放| 欧洲 亚洲 国产图片综合 | 羞羞影院午夜男女爽爽免费| 国产92成人精品视频免费| 永久免费的无码中文字幕| 成人av片在线观看免费| 日韩电影一区二区三区| 国产精品538一区二区在线| 亚洲一区天堂九一| 亚洲综合成人av一区在线观看| 国产欧美性成人精品午夜| 美女张开腿让人桶| 老司机性色福利精品视频| 亚洲男同gv在线观看|