在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 試劑盒
  3. 酶聯免疫試劑盒
  4. Rat Kidney injury molecule 1,Kim-1 ELISA Kit

Rat Kidney injury molecule 1,Kim-1 ELISA Kit

  • 中文名稱：
    大鼠腎損傷分子1(Kim-1)酶聯免疫試劑盒
  • 貨號：
    CSB-E08808r
  • 規格：
    96T/48T
  • 價格：
    ￥3900/￥2500
  • 其他：

產品詳情

  • 產品描述：
    大鼠腎損傷分子1(Kim-1)酶聯免疫試劑盒（CSB-E08808r）為雙抗夾心法ELISA試劑盒，定量檢測血清、血漿、尿液樣本中的Kim-1含量。試劑盒檢測范圍為0.313 ng/mL-20 ng/mL，靈敏度為0.228 ng/mL。支持科研人員開展藥物腎毒性評估、腎臟疾病動物模型動態監測或生物標志物篩選等研究，Kim - 1在急性腎損傷的早期診斷及病理機制研究中具有重要科研價值。本品僅用于科研，不用于臨床診斷，產品具體參數及操作步驟詳見產品說明書。
  • 別名：
    Havcr1; Kim1; Hepatitis A virus cellular receptor 1 homolog; HAVcr-1; Kidney injury molecule 1; KIM-1; T cell immunoglobulin and mucin domain-containing protein 1; TIMD-1; CD antigen CD365
  • 縮寫：
    Kim-1
  • Uniprot No.：
  • 種屬：
    Rattus norvegicus (Rat)
  • 樣本類型：
    serum, plasma, urine
  • 檢測范圍：
    0.313 ng/mL-20 ng/mL
  • 靈敏度：
    0.228 ng/mL
  • 反應時間：
    1-5h
  • 樣本體積：
    50-100ul
  • 檢測波長：
    450 nm
  • 研究領域：
    Immunology
  • 測定原理：
    quantitative
  • 測定方法：
    Sandwich
  • 精密度：

    Intra-assay Precision (Precision within an assay): CV%<8%
    Three samples of known concentration were tested twenty times on one plate to assess.
    Inter-assay Precision (Precision between assays): CV%<10%
    Three samples of known concentration were tested in twenty assays to assess.

  • 線性度：

    To assess the linearity of the assay, samples were spiked with high concentrations of Rat Kim-1 in various matrices and diluted with the Sample Diluent to produce samples with values within the dynamic range of the assay.

  • 標準曲線：

    These standard curves are provided for demonstration only. A standard curve should be generated for each set of samples assayed.

  • 數據處理：
  • 貨期：
    3-5 working days

引用文獻

產品評價

靶點詳情

  • 最新研究進展：
    Kim-1是一種腎小管損傷標志物，也稱為Timm-1，是由跨膜蛋白質編碼的蛋白質，其全稱為腎小管上皮細胞生長因子相關分子-1（Kidney injury molecule-1）。Kim-1的表達受腎小管損傷的調控，已被證明對于腎臟疾病的早期診斷和監測有很大的幫助。
    最近的研究表明，Kim-1可能與腎臟外的許多其他疾病有關，例如心血管疾病、糖尿病和肝臟疾病。此外，一些研究還探討了Kim-1在腎移植領域中的應用，包括在腎移植后的預后評估、排斥反應的診斷和治療方案的制定中的作用。
  • 功能：
    May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4. May play a role in kidney injury and repair.
  • 基因功能參考文獻：
    1. High KIM1 expression is associated with decreased proximal tubular epithelial cell function. PMID: 29045706
    2. urinary KIM1 may be a valuable biomarker for the early diagnosis of obstructive AKI, and the use of a colloidal gold immunochromatographic strip may be a promising method for the rapid detection of urinary KIM1. PMID: 28075469
    3. Results show that in contrast to other known molecules indicating renal injury and/or repair mechanisms, the chronic renal expression of Kim-1 is strictly confined to proximal cysts. PMID: 27231899
    4. blood biomarker that specifically reflects acute and chronic kidney injury PMID: 24904085
    5. Ischemic postconditioning can attenuate the renal ischemia reperfusion injury and downregulate the expression of Kim-1. PMID: 22898836
    6. These studies are the first direct demonstration of regulation of KIM-1 in response to oxalate exposure in renal epithelial cells in vitro and in vivo. PMID: 22984472
    7. The most sensitive, noninvasive biomarkers of HCBD-induced renal toxicity in Hanover Wistar rats were urinary alpha-GST and KIM-1. PMID: 21905055
    8. The Kim1 gene is regulated in an epigenetic fashion under conditions of nephrotoxicity. PMID: 20660082
    9. Results show Kim-1 outperforms SCr, BUN and urinary NAG in multiple rat models of kidney injury. PMID: 20458318
    10. KIM-1 as a sensitive molecular marker of different levels of tubular injury PMID: 20305092
    11. Urinary Kim-1 serve as a noninvasive, rapid, sensitive, reproducible method to detect early kidney injury in pathophysiological studies and in preclinical drug development studies for risk-benefit profiling of pharmaceutical agents. PMID: 16174863
    12. These results implicate involvement of kidney injury molecule 1 (Kim-1) in the pathogenesis of proteinuria-induced renal damage/repair. Urinary Kim-1 levels may serve as a marker of proteinuria-induced renal damage. PMID: 16467126
    13. Kim-1 is associated with development of renin-angiotensin system-mediated renal damage PMID: 16896183
    14. Urinary Kim-1 and kidney Kim-1/Havcr1 expression appear to be sensitive and tissue-specific biomarkers that will improve detection of early acute kidney injury PMID: 17934191
    15. Data demonstrate that injured kidney epithelial cells assumed attributes of endogenous phagocytes, and that KIM-1 was directly responsible for phagocytosis in cultured primary rat tubule epithelial cells and also porcine and canine epithelial cell lines. PMID: 18414680
    16. on longitudinal follow-up during antiproteinuric treatment increased renal Kim-1 expression is reversible in proportion to proteinuria reduction, likely reflecting reversibility of early tubular injury PMID: 19225054
    17. Cadmium-induced increase in Kim-1 expression occurs before the onset of necrosis and at a point where there is only a modest level of apoptosis in the proximal tubule. PMID: 19371613
    18. Kim-1 is a sensitive biomarker of the early stages of Cadmium-induced proximal tubule injury. PMID: 19371616
    19. Dipsticks can provide a sensitive and accurate detection of Havcr1. PMID: 19387469
    20. Kim-1 is a promising novel marker for the early, organ specific and noninvasive detection of brain death-induced donor kidney damage. PMID: 19522876

    顯示更多

    收起更多

  • 亞細胞定位：
    Membrane; Single-pass type I membrane protein.
  • 蛋白家族：
    Immunoglobulin superfamily, TIM family
  • 組織特異性：
    Expressed at a low level in normal kidney but are increased dramatically in postischemic kidney. Expressed in proliferating bromodeoxyuridine-positive and dedifferentiated vimentin-positive epithelial cells in regenerating proximal tubules.
  • 數據庫鏈接：


主站蜘蛛池模板： 久久婷婷五月综合色国产香蕉 | 女人18毛片水最多| 国产成人综合在线女婷五月99播放| 天堂岛国av无码免费无禁网站| 亚洲欧美日韩中文在线制服 | 无码一区二区三区| 亚洲精品欧美精品日韩精品| 国产精品久久国产精麻豆99网站 | 国产欧美综合一区二区三区| 又色又爽又黄的吃奶视频免费观看| 亚洲va中文字幕无码久久不卡| 久久精品国产精品国产精品污| 国产精品99久久免费黑人人妻| 激情综合激情五月俺也去| 无码人妻少妇久久中文字幕蜜桃| 成人午夜福利视频| 国产精品久久久久野外| 日韩在线一区二区不卡视频| 亚洲欧美中文高清在线专区 | 亚洲色偷偷偷网站色偷一区 | 国产av福利久久| 天堂网在线观看| 久久无码人妻丰满熟妇区毛片| 国产一二三四区乱码免费| 2019久久久最新精品| 国产精品亚韩精品无码a在线| 国产精品亚洲一区二区三区喷水| 无码东京热一区二区三区| 中文字幕中文乱码www| 成人免费看片又大又黄| 亚洲婷婷六月的婷婷| 麻豆国产成人av高清在线观看| 中国无码人妻丰满熟妇啪啪软件| 亚洲乱码国产乱码精品精大量| 伊人蕉影院久亚洲高清| 国产真实的和子乱拍在线观看| 国产午夜无码视频在线观看| 精品成人免费国产片| 久久天堂av综合合色| 天天拍天天看天天做| 欧美成va视频网站|