在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Pig Stimulator of interferon genes protein (TMEM173)

  • 中文名稱:
    野豬TMEM173重組蛋白
  • 貨號:
    CSB-CF023754PI
  • 規格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產品詳情

  • 基因名:
  • Uniprot No.:
  • 別名:
    STING1; TMEM173; Stimulator of interferon genes protein; poSTING; Transmembrane protein 173
  • 種屬:
    Sus scrofa (Pig)
  • 蛋白長度:
    Full length protein
  • 表達區域:
    1-378
  • 氨基酸序列
    MPYSSLHPSIPQPRGLRAQVAALVLLGACLVALWGLGELPEYTLRWLVLHLASQQIGLLV KGLCSLAEELCHVHSRYQSSYWRAARACLGCPIRCGALLLLSCYFYFSIRDKAGLPLPWM LALLGLSQALNILLGLQHLAPAEVSAICEKRNFNVAHGLAWSYYIGYLRLILPGLRARIQ AYNQRHKNVLGGIGNHRLHILFPLDCGVPDDLSVADPNIRFLHELPQQSADRAGIKGRVY TNSIYELLENGQPAGVCVLGYATPLQTLFAMSQDGRAGFSREDRLEQAKLFCRTLEDILA DAPEAQNNCRLIVYQEPTEGGSFSLSQEILRHLRQEEREVTMGSAETSVVPTSSTLSQEP ELLISGMEQPLPLRSDIF
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by binding cyclic dinucleotides: recognizes and binds cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced by CGAS in response to DNA virus in the cytosol. Upon binding of c-di-GMP or cGAMP, STING1 oligomerizes, translocates from the endoplasmic reticulum and is phosphorylated by TBK1 on the pLxIS motif, leading to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent anti-viral state. In addition to promote the production of type I interferons, plays a direct role in autophagy. Following cGAMP-binding, STING1 buds from the endoplasmic reticulum into COPII vesicles, which then form the endoplasmic reticulum-Golgi intermediate compartment (ERGIC). The ERGIC serves as the membrane source for WIPI2 recruitment and LC3 lipidation, leading to formation of autophagosomes that target cytosolic DNA or DNA viruses for degradation by the lysosome. The autophagy- and interferon-inducing activities can be uncoupled and autophagy induction is independent of TBK1 phosphorylation. Autophagy is also triggered upon infection by bacteria: following c-di-GMP-binding, which is produced by live Gram-positive bacteria, promotes reticulophagy. Exhibits 2',3' phosphodiester linkage-specific ligand recognition: can bind both 2'-3' linked cGAMP (2'-3'-cGAMP) and 3'-3' linked cGAMP but is preferentially activated by 2'-3' linked cGAMP. The preference for 2'-3'-cGAMP, compared to other linkage isomers is probably due to the ligand itself, whichs adopts an organized free-ligand conformation that resembles the STING1-bound conformation and pays low energy costs in changing into the active conformation. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II).
  • 基因功能參考文獻:
    1. the cloning and characterization of porcine STING (poSTING) PMID: 20346968
  • 亞細胞定位:
    Endoplasmic reticulum membrane; Multi-pass membrane protein. Cytoplasm, perinuclear region. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein. Mitochondrion outer membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    TMEM173 family
  • 組織特異性:
    Expressed at higher level in the spleen, lymph node, lung and bone marrow, followed by the small intestine, heart, liver and brain, and to a lesser extent in the stomach and kidney.
  • 數據庫鏈接:


主站蜘蛛池模板: 亚洲精品一区二区国产精华液| 午夜dv内射一区区| 婷婷无套内射影院| 亚洲不乱码卡一卡二卡4卡5| a狠狠久久蜜臀婷色中文网| 久久国产乱子精品免费女| 久久青青草免费线频观| 夫妇交换性三中文字幕| 国产精品无码专区在线观看 | 国产丝袜一区视频在线观看| 色婷婷av99xx| 免费夜色污私人影院在线观看| 午夜免费国产体验区免费的 | 全部孕妇毛片丰满孕妇孕交 | 99精品视频在线观看免费| 久久电影网午夜鲁丝片免费| 老妇高潮潮喷到猛进猛出| 亚洲精品国产精品国产自2022| 精品无码成人片一区二区| 国产成人精品免高潮在线观看| 国产精品婷婷久久爽一下| 99国产精品久久久久久久成人| 日本高清www午色夜在线视频 | 小妖精又紧又湿高潮h视频69| 国产乱子伦农村叉叉叉| 99久久亚洲综合精品成人| 亚洲男人天堂| 日本电影一区二区三区| 日日碰狠狠躁久久躁2023| 欧美精品黑人粗大| 国产在线98福利播放视频| 亚洲丁香五月天缴情综合| 精品一区二区不卡无码av| 永久免费的av片在线电影网| 精品一区二区三区国产在线观看| 亚洲6080yy久久无码产自国产 | 精品一区二区三区国产在线观看 | 久久婷婷五月综合97色一本一本| 久久久久久久无码高潮| 免费女上男下xx00xx00视频| 精品国产一区二区三区免费|