在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Pig Stimulator of interferon genes protein (TMEM173), partial

  • 中文名稱:
    野豬TMEM173重組蛋白
  • 貨號:
    CSB-YP023754PI1
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    野豬TMEM173重組蛋白
  • 貨號:
    CSB-EP023754PI1
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    野豬TMEM173重組蛋白
  • 貨號:
    CSB-EP023754PI1-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    野豬TMEM173重組蛋白
  • 貨號:
    CSB-BP023754PI1
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    野豬TMEM173重組蛋白
  • 貨號:
    CSB-MP023754PI1
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    STING1; TMEM173; Stimulator of interferon genes protein; poSTING; Transmembrane protein 173
  • 種屬:
    Sus scrofa (Pig)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Facilitator of innate immune signaling that acts as a sensor of cytosolic DNA from bacteria and viruses and promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Acts by binding cyclic dinucleotides: recognizes and binds cyclic di-GMP (c-di-GMP), a second messenger produced by bacteria, and cyclic GMP-AMP (cGAMP), a messenger produced by CGAS in response to DNA virus in the cytosol. Upon binding of c-di-GMP or cGAMP, STING1 oligomerizes, translocates from the endoplasmic reticulum and is phosphorylated by TBK1 on the pLxIS motif, leading to recruitment and subsequent activation of the transcription factor IRF3 to induce expression of type I interferon and exert a potent anti-viral state. In addition to promote the production of type I interferons, plays a direct role in autophagy. Following cGAMP-binding, STING1 buds from the endoplasmic reticulum into COPII vesicles, which then form the endoplasmic reticulum-Golgi intermediate compartment (ERGIC). The ERGIC serves as the membrane source for WIPI2 recruitment and LC3 lipidation, leading to formation of autophagosomes that target cytosolic DNA or DNA viruses for degradation by the lysosome. The autophagy- and interferon-inducing activities can be uncoupled and autophagy induction is independent of TBK1 phosphorylation. Autophagy is also triggered upon infection by bacteria: following c-di-GMP-binding, which is produced by live Gram-positive bacteria, promotes reticulophagy. Exhibits 2',3' phosphodiester linkage-specific ligand recognition: can bind both 2'-3' linked cGAMP (2'-3'-cGAMP) and 3'-3' linked cGAMP but is preferentially activated by 2'-3' linked cGAMP. The preference for 2'-3'-cGAMP, compared to other linkage isomers is probably due to the ligand itself, whichs adopts an organized free-ligand conformation that resembles the STING1-bound conformation and pays low energy costs in changing into the active conformation. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II).
  • 基因功能參考文獻:
    1. the cloning and characterization of porcine STING (poSTING) PMID: 20346968
  • 亞細胞定位:
    Endoplasmic reticulum membrane; Multi-pass membrane protein. Cytoplasm, perinuclear region. Endoplasmic reticulum-Golgi intermediate compartment membrane; Multi-pass membrane protein. Cytoplasmic vesicle, autophagosome membrane; Multi-pass membrane protein. Mitochondrion outer membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    TMEM173 family
  • 組織特異性:
    Expressed at higher level in the spleen, lymph node, lung and bone marrow, followed by the small intestine, heart, liver and brain, and to a lesser extent in the stomach and kidney.
  • 數據庫鏈接:


主站蜘蛛池模板: 亚洲精品久久一区二区三区四区| 色两性网欧美| 久久99精品国产.久久久久| 无码人妻精品丰满熟妇区| 国产成人午夜无码电影在线观看| 日韩高清国产一区在线| 成人h视频在线观看| 久久亚洲人成综合网| 欧美亚洲日本日韩在线| 精品久久久久久中文字幕人妻最新| 最近最新中文字幕高清免费| 国产精品久久久久久久久免费 | 精品国产免费观看久久久| 果冻传媒亚洲区二期| 欧美日韩在线视频| 玩弄人妻少妇500系列网址| 国产午夜a理论毛片| 日本大片免费观看视频| 中文字幕被公侵犯的漂亮人妻| 亚洲精品www久久久久久 | 亚洲国产精品第一区二区三区| 亚洲大码熟女在线| 中文字幕乱码人妻综合二区三区| 久章草在线精品视频免费观看| 国产免费人成网站x8x8| 大陆极品少妇内射aaaaa| 国产va在线观看免费| 成人无码嫩草影院| 中文字幕亚洲码在线| 欧美另类videosbestsex日本| 在线 无码 中文字幕 强 乱| 精品午夜中文字幕熟女人妻在线| 久碰人妻人妻人妻人妻人掠| 国产午夜成人av在线播放| 丁香五月激情综合国产| 2021国产精品午夜久久| 人妻夜夜爽天天爽三区丁香花| 国产精品视频一区二区三区无码 | 国产超薄肉色丝袜视频| 国产精品卡一卡2卡3卡4| 天天摸日日摸狠狠添|