在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Thyrotropin-releasing hormone receptor (Trhr)

  • 中文名稱:
    小鼠Trhr重組蛋白
  • 貨號:
    CSB-CF024441MO
  • 規格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產品詳情

  • 基因名:
  • Uniprot No.:
  • 別名:
    Trhr; Thyrotropin-releasing hormone receptor; TRH-R; Thyroliberin receptor
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Full length protein
  • 表達區域:
    1-393
  • 氨基酸序列
    MENDTVSEMNQTELQPQAAVALEYQVVTILLVVIICGLGIVGNIMVVLVVMRTKHMRTPT NCYLVSLAVADLMVLVAAGLPNITDSIYGSWVYGYVGCLCITYLQYLGINASSCSITAFT IERYIAICHPIKAQFLCTFSRAKKIIIFVWAFTSIYCMLWFFLLDLNISTYKNAVVVSCG YKISRNYYSPIYLMDFGVFYVVPMILATVLYGFIARILFLNPIPSDPKENSKMWKNDSIH QNKNLNLNATNRCFNSTVSSRKQVTKMLAVVVILFALLWMPYRTLVVVNSFLSSPFQENW FLLFCRICIYLNSAINPVIYNLMSQKFRAAFRKLCNCKQKPTEKAANYSVALNYSVIKES DRFSTELEDITVTDTYVSTTKVSFDDTCLASEN
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway.
  • 基因功能參考文獻:
    1. activating TRH/TRH-R1 signaling seems not to be sufficient for gastric stimulation of acylated ghrelin production PMID: 25490146
    2. The central nervous systems effects of taltirelin are mediated primarily by TRH-R1 and not TRH-R2. PMID: 23303050
    3. We suggest that persistent signaling by TRHRs is exhibited when sufficient levels of agonist/receptor/G-protein complexes are established and maintained and that TRH-R2 forms and maintains these complexes more efficiently than TRH-R1. PMID: 22593547
    4. three distinct and discontinuous regions of the TSHR (aa 246-260 and 277-296 on the TSHR A subunit) and aa 381-385 (on the TSHR B subunit) fold together to form a complex TSH binding pocket. PMID: 12593718
    5. the TSHR may not be similar to other model proteins used to define the concept of central immune tolerance. PMID: 14630711
    6. TRH-R1 has a role in mouse lactation and mice lacking the receptor show signs of central hypothyroidism PMID: 14988432
    7. Thyrotropin-releasing hormone binding induces separation of cytoplasmic ends of TRH receptor type 1 transmembrane helix 5 (TMH5) and TMH6 and a rotation of TMH6 that could promote interactions between G proteins and key residues within the TRH receptor. PMID: 15709754
    8. Beta-arrestin has a role in desensitization and internalization but not phosphorylation of the thyrotropin-releasing hormone receptor, which causes translocation of endogenous GRK2 to the plasma membrane PMID: 16183993
    9. the endogenous TRH system is involved in mood regulation, and this function is carried out through TRH-R1-mediated neural pathways PMID: 17666589
    10. A flexible molecular docking procedure revealed that TRH establishes a direct interaction with W6.48 in TRH-R2 but not in TRH-R1. PMID: 17979196
    11. Direct TRH receptor-mediated excitation of histaminergic tuberomamillary neurons by thyrotropin-releasing hormone demands activation of nonselective cation channels as well as electrogenic sodium/divalent calcium ion exchange. PMID: 19357273

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 1 family
  • 數據庫鏈接:


主站蜘蛛池模板: 久热在线播放中文字幕| 欧美饥渴熟妇高潮喷水| 日韩人妻无码精品专区综合网| 久久综合九色综合国产| 西西人体www大胆高清视频| 麻豆国产尤物av尤物在线观看| 免费观看的av在线播放| 亚洲欧洲精品a片久久99| 可以免费观看的av毛片下载| 亚洲欧洲自拍拍偷午夜色 | 亚洲精品久久久无码av片软件| 久久ee热这里只有精品| 国产又色又爽又黄的免费| 成熟了的熟妇毛茸茸| 另类亚洲综合区图片区小说| 亚洲国产精品第一区二区三区| 久久久免费无码成人影片| 男女性爽大片视频| 在线观看国产成人av片| 久久精品国产只有精品96| 97精品超碰一区二区三区| 亚洲一区二区三区写真| 337p人体 欧洲人体 亚洲| 国产精品高潮呻吟av久久男男 | 一边吃奶一边添p好爽高清视频| 日韩夜夜高潮夜夜爽无码| 8av国产精品爽爽ⅴa在线观看 | 国产百合互慰吃奶互揉视频| 丰满人妻一区二区三区免费视频| 风流少妇按摩来高潮| 国色天香网www在线观看| 纯爱无遮挡h肉动漫在线播放| 久久人人爽av亚洲精品天堂| 中国国产野外1级毛片视频| 天天摸天天做天天添欧美| 中国美女毛茸茸撒尿| 成人免费看吃奶视频网站| 欧洲熟妇色xxxxx欧美| 五月婷婷久久草丁香| 日日摸日日添日日碰9学生露脸| 国产又爽又黄又刺激的视频|