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  4. Recombinant Mouse Gastrin-releasing peptide receptor (Grpr)

Recombinant Mouse Gastrin-releasing peptide receptor (Grpr)

  • 中文名稱：
    小鼠Grpr重組蛋白
  • 貨號：
    CSB-CF009943MO
  • 規格：
  • 來源：
    in vitro E.coli expression system
  • 其他：

產品詳情

  • 基因名：
  • Uniprot No.：
  • 別名：
    Grpr; Gastrin-releasing peptide receptor; GRP-R; GRP-preferring bombesin receptor
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full length protein
  • 表達區域：
    1-384
  • 氨基酸序列
    MAPNNCSHLNLDVDPFLSCNDTFNQSLSPPKMDNWFHPGFIYVIPAVYGLIIVIGLIGNI TLIKIFCTVKSMRNVPNLFISSLALGDLLLLVTCAPVDASKYLADRWLFGRIGCKLIPFI QLTSVGVSVFTLTALSADRYKAIVRPMDIQASHALMKICLKAALIWIVSMLLAIPEAVFS DLHPFHVKDTNQTFISCAPYPHSNELHPKIHSMASFLVFYVIPLAIISVYYYFIARNLIQ SAYNLPVEGNIHVKKQIESRKRLAKTVLVFVGLFAFCWLPNHVIYLYRSYHYSEVDTSML HFVTSICARLLAFTNSCVNPFALYLLSKSFRKQFNTQLLCCQPGLMNRSHSTGRSTTCMT SFKSTNPSATFSLINRNICHEGYV
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽：
    N-terminal 10xHis-tagged
  • 產品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Receptor for gastrin-releasing peptide (GRP). Signals via association with G proteins that activate a phosphatidylinositol-calcium second messenger system, resulting in Akt phosphorylation. Contributes to the regulation of food intake. Contributes to the perception of prurient stimuli and transmission of itch signals in the spinal cord that promote scratching behavior, but does not play a role in the perception of pain. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory.
  • 基因功能參考文獻：
    1. These data suggest that GRPR expression in fibroblast-like synoviocytes (FLS)and that exogenous GRP are able to activate FLS invasion. This effect occurs at least in part through the AKT activation. Therefore, understanding of the GRP/GRPR pathway could be relevant in the development of FLS-targeted therapy for Rheumatoid arthritis . PMID: 28733141
    2. ablating GRP receptor-expressing neurons eliminated basal and hypoxia-induced sighing, but left breathing otherwise intact initially PMID: 26855425
    3. Together, we define the respective function of NMBR and GRPR in itch transmission, and reveal an unexpected relationship not only between the two receptors but also between the two populations of interneurons in itch signaling. PMID: 25209280
    4. BNP-NPRA signaling is involved in both itch and pain and does not function upstream of the GRP-GRPR dedicated neuronal pathway. PMID: 24438367
    5. The present results suggest that BB2 receptor-expressing spinal neurons transmit herpes-associated itch by BB2 receptor-independent signaling. PMID: 23778077
    6. spinal GRPr and NMBr independently drive itch neurotransmission in mice. PMID: 23826298
    7. GRPR and stathmin control in opposite directions both cued fear extinction and neural activities of the amygdala and prefrontal cortex PMID: 22312434
    8. Gastrin-releasing peptide receptor mediates chemotaxis in neutrophils, and may be an alternative chemotactic receptor playing a role in the pathogenesis of inflammatory disorders. PMID: 22203955
    9. The data suggest that opioid-induced itch is an active process concomitant with but independent of opioid analgesia, occurring via the unidirectional cross-activation of GRPR signaling by MOR1D heterodimerization PMID: 22000021
    10. We propose that deletion of GRPR leads to the induction of depression-like behavior which is paralleled by dysregulation of amygdala gene expression, potentially resulting from deficient light-induced corticosterone release in GRPR-knockout mice PMID: 21254899
    11. GRP-R-deficient mice showed no significant different in risk assessment behavior of conventional anxiwety parameters, so GRP-R may not impact this anxiety or emotional behavior. PMID: 11803457
    12. GRP/GRP-R play a transient and non-critical role in intestinal development PMID: 11960700
    13. GRPR has a role in regulation of fear and memory for fear in the mouse amygdala PMID: 12526815
    14. GRPR gene expression was detected predominantly in utero in lung development PMID: 12959933
    15. MCH was significantly enhanced in BRS-3-deficient mice but not in GRP-R-deficient mice PMID: 14988239
    16. GRP-R immunoreactivity was observed in the lateral (LA), central, and basolateral amygdaloid (BLA) nuclei and NTS, which are important regions for memory performance. PMID: 15680955
    17. Changes in GRPr are light driven and not endogenously organized. Diurnal variation in GRPr activity probably underlies intra-SCN signaling important for entrainment and phase shifting. PMID: 16519669
    18. GRPR may represent the first molecule that is dedicated to mediating the itch sensation in the dorsal horn of the spinal cord PMID: 17653196
    19. New evidence for the occurrence of marked effects of bombesin/gastrin-releasing peptide concerning both the articular chondrocytes and the inflammatory process is obtained in this study PMID: 17911468
    20. These findings demonstrate that GRP and GRP-R have important oncogenic properties beyond their established mitogenic functions. PMID: 18753628

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  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 組織特異性：
    Detected in pancreas and brain. Detected in suprachaismatic nucleus neurons. Detected in neurons in the dorsal horn of the spinal cord. Detected in inhibitory GABAergic interneurons in the lateral nucleus of the amygdala.
  • 數據庫鏈接：


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