在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Gastrin-releasing peptide receptor (Grpr), partial

Recombinant Mouse Gastrin-releasing peptide receptor (Grpr), partial

  • 中文名稱：
    小鼠Grpr重組蛋白
  • 貨號：
    CSB-YP009943MO1
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Grpr重組蛋白
  • 貨號：
    CSB-EP009943MO1
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Grpr重組蛋白
  • 貨號：
    CSB-EP009943MO1-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Grpr重組蛋白
  • 貨號：
    CSB-BP009943MO1
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Grpr重組蛋白
  • 貨號：
    CSB-MP009943MO1
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Grpr; Gastrin-releasing peptide receptor; GRP-R; GRP-preferring bombesin receptor
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Receptor for gastrin-releasing peptide (GRP). Signals via association with G proteins that activate a phosphatidylinositol-calcium second messenger system, resulting in Akt phosphorylation. Contributes to the regulation of food intake. Contributes to the perception of prurient stimuli and transmission of itch signals in the spinal cord that promote scratching behavior, but does not play a role in the perception of pain. Contributes primarily to nonhistaminergic itch sensation. Contributes to long-term fear memory, but not normal spatial memory.
  • 基因功能參考文獻：
    1. These data suggest that GRPR expression in fibroblast-like synoviocytes (FLS)and that exogenous GRP are able to activate FLS invasion. This effect occurs at least in part through the AKT activation. Therefore, understanding of the GRP/GRPR pathway could be relevant in the development of FLS-targeted therapy for Rheumatoid arthritis . PMID: 28733141
    2. ablating GRP receptor-expressing neurons eliminated basal and hypoxia-induced sighing, but left breathing otherwise intact initially PMID: 26855425
    3. Together, we define the respective function of NMBR and GRPR in itch transmission, and reveal an unexpected relationship not only between the two receptors but also between the two populations of interneurons in itch signaling. PMID: 25209280
    4. BNP-NPRA signaling is involved in both itch and pain and does not function upstream of the GRP-GRPR dedicated neuronal pathway. PMID: 24438367
    5. The present results suggest that BB2 receptor-expressing spinal neurons transmit herpes-associated itch by BB2 receptor-independent signaling. PMID: 23778077
    6. spinal GRPr and NMBr independently drive itch neurotransmission in mice. PMID: 23826298
    7. GRPR and stathmin control in opposite directions both cued fear extinction and neural activities of the amygdala and prefrontal cortex PMID: 22312434
    8. Gastrin-releasing peptide receptor mediates chemotaxis in neutrophils, and may be an alternative chemotactic receptor playing a role in the pathogenesis of inflammatory disorders. PMID: 22203955
    9. The data suggest that opioid-induced itch is an active process concomitant with but independent of opioid analgesia, occurring via the unidirectional cross-activation of GRPR signaling by MOR1D heterodimerization PMID: 22000021
    10. We propose that deletion of GRPR leads to the induction of depression-like behavior which is paralleled by dysregulation of amygdala gene expression, potentially resulting from deficient light-induced corticosterone release in GRPR-knockout mice PMID: 21254899
    11. GRP-R-deficient mice showed no significant different in risk assessment behavior of conventional anxiwety parameters, so GRP-R may not impact this anxiety or emotional behavior. PMID: 11803457
    12. GRP/GRP-R play a transient and non-critical role in intestinal development PMID: 11960700
    13. GRPR has a role in regulation of fear and memory for fear in the mouse amygdala PMID: 12526815
    14. GRPR gene expression was detected predominantly in utero in lung development PMID: 12959933
    15. MCH was significantly enhanced in BRS-3-deficient mice but not in GRP-R-deficient mice PMID: 14988239
    16. GRP-R immunoreactivity was observed in the lateral (LA), central, and basolateral amygdaloid (BLA) nuclei and NTS, which are important regions for memory performance. PMID: 15680955
    17. Changes in GRPr are light driven and not endogenously organized. Diurnal variation in GRPr activity probably underlies intra-SCN signaling important for entrainment and phase shifting. PMID: 16519669
    18. GRPR may represent the first molecule that is dedicated to mediating the itch sensation in the dorsal horn of the spinal cord PMID: 17653196
    19. New evidence for the occurrence of marked effects of bombesin/gastrin-releasing peptide concerning both the articular chondrocytes and the inflammatory process is obtained in this study PMID: 17911468
    20. These findings demonstrate that GRP and GRP-R have important oncogenic properties beyond their established mitogenic functions. PMID: 18753628

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    G-protein coupled receptor 1 family
  • 組織特異性：
    Detected in pancreas and brain. Detected in suprachaismatic nucleus neurons. Detected in neurons in the dorsal horn of the spinal cord. Detected in inhibitory GABAergic interneurons in the lateral nucleus of the amygdala.
  • 數據庫鏈接：


主站蜘蛛池模板： 伊人色综合网一区二区三区| 免费特级黄毛片| 国产精品一线二线三线| 国模大尺度啪啪| 在线观看免费人成视频网| 亚洲中文久久精品无码1| 青青草原综合久久大伊人| 荫蒂添的好舒服视频囗交| 午夜福利电影网站鲁片大全| 熟妇人妻不卡中文字幕| 色偷偷偷久久伊人大杳蕉| а√天堂8资源在线官网| 日本丰满少妇裸体自慰| 无码av中文字幕免费放| 国产精品国产三级在线...| 久久久久久无码午夜精品直播| 国产乱人激情h在线观看| 日本熟妇人妻xxxxx人hd| 亚洲一卡2卡三卡4卡无卡下载| 大肉大捧一进一出好爽视频mba | 超碰97人人让你爽| 免费人成激情视频在线观看冫| 精品亚洲一区二区三区四区五区| 成人影院yy111111在线| 亚洲第一a在线观看网站| 精品久久久无码人妻中文字幕| 护士的小嫩嫩好紧好爽| 日本wv一本一道久久香蕉| 国产av无码专区亚洲版综合| 可以看三级的网站| 2020精品自拍视频曝光| 亚洲第一成人网站在线播放| 亚洲国产欧洲综合997久久| 全黄h全肉边做边吃奶视频| 色综合天天综合高清网国产在线| 久久天天躁夜夜躁狠狠躁| 久久99精品国产麻豆婷婷洗澡| 国产成人无码一区二区在线观看| 国产aⅴ激情无码久久久无码| 精品无码专区久久久水蜜桃| 国产女人高潮毛片|