在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 跨膜蛋白
  4. Recombinant Mouse Catechol O-methyltransferase (Comt)

Recombinant Mouse Catechol O-methyltransferase (Comt)

  • 中文名稱：
    Recombinant Mouse Catechol O-methyltransferase(Comt)
  • 貨號：
    CSB-CF005779MO
  • 規格：
  • 來源：
    in vitro E.coli expression system
  • 其他：

產品詳情

  • 基因名：
  • Uniprot No.：
  • 別名：
    Comt; Comt1; Catechol O-methyltransferase
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-265
  • 氨基酸序列
    MLLAAVSLGLLLLAFLLLLRHLGWGLVAIGWFEFVQQPVHNLLMGGTKEQRILRHVQQHAKPGDPQSVLEAIDTYCSEKEWAMNVGDAKGQIMDAVIREYRPSLVLELGAYCGYSAVRMARLLPPGARLLTMEINPDYAAITQQMLDFAGLQDKVSILIGASQDLIPQLKKKYDVDTLDMVFLDHWKDRYLPDTLLLEECGLLRKGTVLLADNVIVPGTPDFLAYVRGSSSFECTHYSSYLEYMKVVDGLEKAVYQGPGSSPVKS
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽：
    N-terminal 10xHis-tagged
  • 產品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液：
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
  • 基因功能參考文獻：
    1. Miroestrol restored uterine COMT expression in beta-naphthoflavone-treated mice. PMID: 26893163
    2. This study report that genetically driven reduction in COMT enzyme activity increased cortical thickness in the prefrontal cortex (PFC) and postero-parieto-temporal cortex of male, but not female adult mice. PMID: 24658585
    3. COMT expression in the hippocampus was significantly reduced by high E2 replacement, implying increased catecholamine levels in the hippocampus of high E2 mice. PMID: 25555360
    4. COMT overexpressing mice display an increase in dopamine release capacity in the striatum, suggesting increased COMT activity may affect dopamine signaling by enhancing synaptic clearance in the cortex and changes in striatal presynaptic dopamine function PMID: 24639487
    5. These data confirm at the level of mouse working memory and human working memory-associated physiology a genetic interaction between COMT and DTNBP1. PMID: 24145376
    6. The results of this study suggest that individual differences in COMT activity do not affect primary reinforcing effects of cocaine in mice. PMID: 23011431
    7. Inhibition of COMT via serotonin binding contributes to pain hypersensitivity. PMID: 22500608
    8. COMT knockout mice were more impulsive compared with wild-type littermates. PMID: 23169629
    9. Data show that in male catechol-O-methyltransferase COMT(-/-)-mice, the total number of T-, and B-lymphocytes from spleen increased but the T-cell proliferative response decreased. PMID: 22658921
    10. decreased COMT activity was associated with some changes in feeding microstructure in rats and mice PMID: 21851556
    11. This study demonistrated that COMT deletion with elevated anxiety in females and suggest that this may be related to a heightened neuroendocrine response to acute stress in COMT KO mice. PMID: 22192380
    12. COMT deficiency in virgin female mice with intact endogenous production of estradiol results in relative protection against atherosclerosis PMID: 22009725
    13. In catechol-O-methyltransferase knock-out mice administration of tetrahydrocannabinol induced a larger increase in exploratory behavior and greater impairment in spatial working memory. PMID: 20631688
    14. Strains with the SINE haplotype (+SINE) have greater Comt1 enzymatic activity. +SINE mice also exhibit behavioral differences in anxiety assays and decreased pain sensitivity. PMID: 20659173
    15. Findings show that Comt1(B2i) (a B2 SINE insertion) results in a relatively modest difference in Comt1 expression and enzyme activity which has a demonstrable behavioral effect across a variety of outbred genetic backgrounds. PMID: 20618449
    16. the source of variation in Comt PMID: 20808911
    17. A lack of S-COMT has a notable brain-area and sex-dependent effect on the O-methylation of dopamine and 3,4-dihydroxyphenylacetic acid in the mouse brain and induces subtle change in social behavior and nociception PMID: 20617305
    18. In the mouse, the prefrontal cortex COMT contributes about one half of the total dopamine clearance. PMID: 20626558
    19. Both soluble COMT and membrane-bound COMT forms were abundantly found in microglial cells and intestinal macrophages, but also in astroglial cells. COMT was also present in some neuronal cells and nuclear COMT is not visible in S-COMT deficient mice. PMID: 20374420
    20. Findings in mice with reduced or absent COMT activity reveal its important role in the dopamine-mediated regulation of renal sodium excretion. PMID: 12188925
    21. First demonstration of the significant contribution of catechol-O-methyltransferase in modulating the dynamics of dopamine overflow in the prefrontal cortex. PMID: 17881525
    22. pregnant mice deficient in catechol-O-methyltransferase (COMT) show a pre-eclampsia-like phenotype resulting from an absence of 2-methoxyoestradiol PMID: 18469803
    23. catechol-O-methyltransferase and neuregulin-1 may influence, respectively, primarily cognitive and social endophenotypes of the overall schizophrenia syndrome. PMID: 18674597
    24. Disruption of Comt gene influenced ethanol consumption in a gender-dependent manner in mice, supporting the hypothesis that low catechol-O-methyltransferase activity is one of the predisposing factors for high alcohol consumption in males. PMID: 18684228

    顯示更多

    收起更多

  • 亞細胞定位：
    [Isoform Soluble]: Cytoplasm.; [Isoform Membrane-bound]: Cell membrane; Single-pass type II membrane protein; Extracellular side.
  • 蛋白家族：
    Class I-like SAM-binding methyltransferase superfamily, Cation-dependent O-methyltransferase family
  • 數據庫鏈接：


主站蜘蛛池模板： 日本大乳高潮视频在线观看| 日本高清一区二区三| 风韵少妇性饥渴推油按摩视频| 日韩免费无码一区二区视频| 国产在线无码一区二区三区| 午夜免费啪在线观看视频| 最近2019免费中文第一页| 国产午夜精品无码| 亚洲综合狠狠丁香五月| 国产午夜草莓视频在线观看| 色综合久久一区二区三区| 男人av无码天堂| 国内精品国语自产拍在线观看| 伊人久久精品无码麻豆一区| 欧美亚洲综合在线一区| 国产精品自在拍在线播放| 日韩人妻潮喷中文在线视频| 国产精品久久久久蜜芽| 日本人妻丰满熟妇久久久久久 | 国产免费一区二区三区不卡| 人妻体内射精一区二区三四| 亚洲精品无码久久久久久久| 青青草国产线观看| 国产精品久久久天天影视香蕉| 胸大美女又黄的网站| 在线看片免费人成视频福利| 欧美激性欧美激情在线| 日韩aⅴ人妻无码一区二区| 午夜欧美精品久久久久久久| 99热亚洲色精品国产88| 羞国产在线拍揄自揄视频| 综合 欧美 亚洲日本| 在线高清亚洲精品二区| 在线观看国产丝袜控网站| 久久精品国产99国产精品| 88久久精品无码一区二区毛片| 国产97色在线 | 日| 精品国产亚洲一区二区三区在线观看| 一区二区三区在线 | 欧| 国产精品久久自在自线不卡| 欧美黑人又粗又大的性格特点|