在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Catechol O-methyltransferase (Comt), partial

Recombinant Mouse Catechol O-methyltransferase (Comt), partial

  • 中文名稱：
    Recombinant Mouse Catechol O-methyltransferase(Comt),partial
  • 貨號：
    CSB-YP005779MO1
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse Catechol O-methyltransferase(Comt),partial
  • 貨號：
    CSB-EP005779MO1
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse Catechol O-methyltransferase(Comt),partial
  • 貨號：
    CSB-EP005779MO1-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse Catechol O-methyltransferase(Comt),partial
  • 貨號：
    CSB-BP005779MO1
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse Catechol O-methyltransferase(Comt),partial
  • 貨號：
    CSB-MP005779MO1
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Comt; Comt1; Catechol O-methyltransferase
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Catalyzes the O-methylation, and thereby the inactivation, of catecholamine neurotransmitters and catechol hormones. Also shortens the biological half-lives of certain neuroactive drugs, like L-DOPA, alpha-methyl DOPA and isoproterenol.
  • 基因功能參考文獻：
    1. Miroestrol restored uterine COMT expression in beta-naphthoflavone-treated mice. PMID: 26893163
    2. This study report that genetically driven reduction in COMT enzyme activity increased cortical thickness in the prefrontal cortex (PFC) and postero-parieto-temporal cortex of male, but not female adult mice. PMID: 24658585
    3. COMT expression in the hippocampus was significantly reduced by high E2 replacement, implying increased catecholamine levels in the hippocampus of high E2 mice. PMID: 25555360
    4. COMT overexpressing mice display an increase in dopamine release capacity in the striatum, suggesting increased COMT activity may affect dopamine signaling by enhancing synaptic clearance in the cortex and changes in striatal presynaptic dopamine function PMID: 24639487
    5. These data confirm at the level of mouse working memory and human working memory-associated physiology a genetic interaction between COMT and DTNBP1. PMID: 24145376
    6. The results of this study suggest that individual differences in COMT activity do not affect primary reinforcing effects of cocaine in mice. PMID: 23011431
    7. Inhibition of COMT via serotonin binding contributes to pain hypersensitivity. PMID: 22500608
    8. COMT knockout mice were more impulsive compared with wild-type littermates. PMID: 23169629
    9. Data show that in male catechol-O-methyltransferase COMT(-/-)-mice, the total number of T-, and B-lymphocytes from spleen increased but the T-cell proliferative response decreased. PMID: 22658921
    10. decreased COMT activity was associated with some changes in feeding microstructure in rats and mice PMID: 21851556
    11. This study demonistrated that COMT deletion with elevated anxiety in females and suggest that this may be related to a heightened neuroendocrine response to acute stress in COMT KO mice. PMID: 22192380
    12. COMT deficiency in virgin female mice with intact endogenous production of estradiol results in relative protection against atherosclerosis PMID: 22009725
    13. In catechol-O-methyltransferase knock-out mice administration of tetrahydrocannabinol induced a larger increase in exploratory behavior and greater impairment in spatial working memory. PMID: 20631688
    14. Strains with the SINE haplotype (+SINE) have greater Comt1 enzymatic activity. +SINE mice also exhibit behavioral differences in anxiety assays and decreased pain sensitivity. PMID: 20659173
    15. Findings show that Comt1(B2i) (a B2 SINE insertion) results in a relatively modest difference in Comt1 expression and enzyme activity which has a demonstrable behavioral effect across a variety of outbred genetic backgrounds. PMID: 20618449
    16. the source of variation in Comt PMID: 20808911
    17. A lack of S-COMT has a notable brain-area and sex-dependent effect on the O-methylation of dopamine and 3,4-dihydroxyphenylacetic acid in the mouse brain and induces subtle change in social behavior and nociception PMID: 20617305
    18. In the mouse, the prefrontal cortex COMT contributes about one half of the total dopamine clearance. PMID: 20626558
    19. Both soluble COMT and membrane-bound COMT forms were abundantly found in microglial cells and intestinal macrophages, but also in astroglial cells. COMT was also present in some neuronal cells and nuclear COMT is not visible in S-COMT deficient mice. PMID: 20374420
    20. Findings in mice with reduced or absent COMT activity reveal its important role in the dopamine-mediated regulation of renal sodium excretion. PMID: 12188925
    21. First demonstration of the significant contribution of catechol-O-methyltransferase in modulating the dynamics of dopamine overflow in the prefrontal cortex. PMID: 17881525
    22. pregnant mice deficient in catechol-O-methyltransferase (COMT) show a pre-eclampsia-like phenotype resulting from an absence of 2-methoxyoestradiol PMID: 18469803
    23. catechol-O-methyltransferase and neuregulin-1 may influence, respectively, primarily cognitive and social endophenotypes of the overall schizophrenia syndrome. PMID: 18674597
    24. Disruption of Comt gene influenced ethanol consumption in a gender-dependent manner in mice, supporting the hypothesis that low catechol-O-methyltransferase activity is one of the predisposing factors for high alcohol consumption in males. PMID: 18684228

    顯示更多

    收起更多

  • 亞細胞定位：
    [Isoform Soluble]: Cytoplasm.; [Isoform Membrane-bound]: Cell membrane; Single-pass type II membrane protein; Extracellular side.
  • 蛋白家族：
    Class I-like SAM-binding methyltransferase superfamily, Cation-dependent O-methyltransferase family
  • 數據庫鏈接：


主站蜘蛛池模板： 国色天香社区视频| 麻豆传传媒久久久爱| 欧美成人午夜精品久久久| 国产精品久久久久9999小说| 成人做爰视频www网站小优视频| 97精品久久天干天天| 日本中文一二区有码在线| 欧美亚洲色欲色一欲www| 日日噜噜夜夜狠狠va视频| 1000部夫妻午夜免费| 久久精品免费一区二区| 亚洲国产综合精品 在线 一区| 亚洲热无码av一区二区东京热av| 2020久久天天躁狠狠躁夜夜| 国产三级在线观看播放视频| 亚洲成av人片在www色猫咪| 亚洲精品97久久中文字幕无码 | 狠狠人妻久久久久久综合| av无码电影一区二区三区| 国产精品卡一卡2卡3卡4| 久久久久免费看黄a片app| 天天躁日日躁狠狠躁欧美老妇小说 | 无码国模大尺度视频在线观看 | 日日狠狠久久8888偷偷色| 久久天天躁夜夜躁狠狠i女人| 国产av久久久久精东av| 欧美性猛交内射兽交老熟妇| 日韩欧美猛交xxxxx无码| 亚洲熟妇色xxxxx欧美老妇| 97色伦综合在线欧美视频| 欲色欲色天天天www| 精品国产一区二区三区久久| 日本sm/羞辱/调教/捆绑视频 | 国模杨依粉嫩蝴蝶150p| 三级4级全黄60分钟| 偷看农村女人做爰毛片色| 国产在线欧美日韩精品一区| 动漫精品视频一区二区三区| 国产亚洲精品俞拍视频| 狠狠躁夜夜躁人人爽蜜桃| 久久久女人与动物群交毛片|