在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse ADP/ATP translocase 2 (Slc25a5)

  • 中文名稱:
    小鼠Slc25a5重組蛋白
  • 貨號:
    CSB-CF021518MO
  • 規格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產品詳情

  • 基因名:
  • Uniprot No.:
  • 別名:
    Slc25a5; Aac2; Ant2; ADP/ATP translocase 2; ADP,ATP carrier protein 2; Adenine nucleotide translocator 2; ANT 2; Solute carrier family 25 member 5
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區域:
    2-298
  • 氨基酸序列
    TDAAVSFAKDFLAGGVAAAISKTAVAPIERVKLLLQVQHASKQITADKQYKGIIDCVVRI PKEQGVLSFWRGNLANVIRYFPTQALNFAFKDKYKQIFLGGVDKRTQFWRYFAGNLASGG AAGATSLCFVYPLDFARTRLAADVGKAGAEREFKGLGDCLVKIYKSDGIKGLYQGFNVSV QGIIIYRAAYFGIYDTAKGMLPDPKNTHIFISWMIAQSVTAVAGLTSYPFDTVRRRMMMQ SGRKGTDIMYTGTLDCWRKIARDEGSKAFFKGAWSNVLRGMGGAFVLVLYDEIKKYT
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    ADP:ATP antiporter that mediates import of ADP into the mitochondrial matrix for ATP synthesis, and export of ATP out to fuel the cell. Cycles between the cytoplasmic-open state (c-state) and the matrix-open state (m-state): operates by the alternating access mechanism with a single substrate-binding site intermittently exposed to either the cytosolic (c-state) or matrix (m-state) side of the inner mitochondrial membrane. In addition to its ADP:ATP antiporter activity, also involved in mitochondrial uncoupling and mitochondrial permeability transition pore (mPTP) activity. Plays a role in mitochondrial uncoupling by acting as a proton transporter: proton transport uncouples the proton flows via the electron transport chain and ATP synthase to reduce the efficiency of ATP production and cause mitochondrial thermogenesis. Proton transporter activity is inhibited by ADP:ATP antiporter activity, suggesting that SLC25A5/ANT2 acts as a master regulator of mitochondrial energy output by maintaining a delicate balance between ATP production (ADP:ATP antiporter activity) and thermogenesis (proton transporter activity). Proton transporter activity requires free fatty acids as cofactor, but does not transport it. Probably mediates mitochondrial uncoupling in tissues that do not express UCP1. Also plays a key role in mPTP opening, a non-specific pore that enables free passage of the mitochondrial membranes to solutes of up to 1.5 kDa, and which contributes to cell death. It is however unclear if SLC25A5/ANT2 constitutes a pore-forming component of mPTP or regulates it. Acts as a regulator of mitophagy independently of ADP:ATP antiporter activity: promotes mitophagy via interaction with TIMM44, leading to inhibit the presequence translocase TIMM23, thereby promoting stabilization of PINK1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation.
  • 基因功能參考文獻:
    1. Deficiency in the mouse mitochondrial ANT2 gene is associated with cardiac noncompaction. PMID: 27048932
    2. IFNgamma induces oxidative stress, DNA damage and tumor cell senescence via TGFbeta/SMAD signaling-dependent induction of Nox4 and suppression of ANT2 PMID: 25982278
    3. Erythroid and B-cell development may be particularly vulnerable to Ant2 depletion-mediated mitochondrial dysfunction and oxidative stress. PMID: 25613378
    4. Sirt4 regulates ATP levels via ANT2 and a feedback loop involving AMPK. PMID: 24296486
    5. The mammalian proteins MMS19, MIP18, and ANT2 are involved in cytoplasmic iron-sulfur cluster protein assembly. PMID: 23150669
    6. ANT2 and ANT1 regulate L1-mediated neurite outgrowth in conjunction with MMP14 at the plasma membrane. PMID: 22423112
    7. ANTs are non-essential structural components of the mitochondrial permeability transition pore, although they do contribute to its regulation PMID: 14749836
    8. In liver only Ant2 mRNA was found, but in brown adipose tissue, Ant1 & Ant2 mRNA levels were equal. The ANT2 isoform may mediate fatty-acid-induced uncoupling. PMID: 16831128
    9. At high protonmotive force, an endogenously generated activator stimulates proton conductance catalysed partly by UCP3 and partly by the adenine nucleotide translocase. PMID: 18251717

    顯示更多

    收起更多

  • 亞細胞定位:
    Mitochondrion inner membrane; Multi-pass membrane protein. Membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Mitochondrial carrier (TC 2.A.29) family
  • 組織特異性:
    Widely expressed.
  • 數據庫鏈接:


主站蜘蛛池模板: 国精品人妻无码一区二区三区性色| 嫩b人妻精品一区二区三区| 消息称老熟妇乱视频一区二区| 思思99re6国产在线播放| 韩国的无码av看免费大片在线| 蜜桃av噜噜一区二区三区| 亚洲日韩成人无码| 黄在线看片免费人成视频 | 成人天堂婷婷青青视频在线观看| av人摸人人人澡人人超碰小说| 草草影院精品一区二区三区| 亚洲成成熟女人专区| 在线观看国产一区二区三区| 亚洲成av人片在线观看无码不卡| 无码专区—va亚洲v天堂麻豆| 免费啪视频在线观看视频网页| 夜夜爽日日澡人人添| 精品熟人妻一区二区三区四区不卡| 亚洲欧美日韩综合在线一| 国产精品星空无限传媒| 久久aⅴ人妻少妇嫩草影院| 国产av无码专区亚洲a∨毛片| 亚洲一区二区三区无码久久| 国产主播av福利精品一区| 国产无遮挡a片无码免费软件| 女厕偷窥一区二区三区| 精品麻豆一区二区三区乱码| 国产精品美女久久久m| 五十路熟女丰满大屁股| 最大胆裸体人体牲交| 五月婷六月婷婷俺也去| 亚洲欧洲无码av一区二区三区 | 亚洲中文无码线在线观看| 99re久久精品国产| 免费男人下部进女人下部视频| 97精品国产久热在线观看| 欧美交换国产一区内射| 国产成人一区二区三区别| 国产又黄又潮娇喘视频在线观看| 欧美人伦禁忌dvd放荡欲情| 国产精品9999久久久久仙踪林|