在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human UDP-glucuronosyltransferase 1A8 (UGT1A8)-VLPs

  • 中文名稱:
    Recombinant Human UDP-glucuronosyltransferase 1A8 (UGT1A8)-VLPs
  • 貨號:
    CSB-MP867187HU
  • 規格:
  • 其他:

產品詳情

  • 基因名:
    UGT1A8
  • Uniprot No.:
  • 別名:
    (UGT1A8)(UDP-glucuronosyltransferase 1-8)(UDPGT 1-8)(UGT1*8)(UGT1-08)(UGT1.8)(UDP-glucuronosyltransferase 1-H)(UGT-1H)(UGT1H)
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Mature Protein
  • 來源:
    Mammalian cell
  • 表達區域:
    26-530aa
  • 氨基酸序列
    GKLLVVPMDGSHWFTMQSVVEKLILRGHEVVVVMPEVSWQLGKSLNCTVKTYSTSYTLEDLDREFMDFADAQWKAQVRSLFSLFLSSSNGFFNLFFSHCRSLFNDRKLVEYLKESSFDAVFLDPFDACGLIVAKYFSLPSVVFARGIACHYLEEGAQCPAPLSYVPRILLGFSDAMTFKERVRNHIMHLEEHLFCQYFSKNALEIASEILQTPVTAYDLYSHTSIWLLRTDFVLDYPKPVMPNMIFIGGINCHQGKPLPMEFEAYINASGEHGIVVFSLGSMVSEIPEKKAMAIADALGKIPQTVLWRYTGTRPSNLANNTILVKWLPQNDLLGHPMTRAFITHAGSHGVYESICNGVPMVMMPLFGDQMDNAKRMETKGAGVTLNVLEMTSEDLENALKAVINDKSYKENIMRLSSLHKDRPVEPLDLAVFWVEFVMRHKGAPHLRPAAHDLTWYQYHSLDVIGFLLAVVLTVAFITFKCCAYGYRKCLGKKGRVKKAHKSKTH
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    C-terminal 10xHis-tagged
    If you have specified tag type, please tell us and we will check if it's possible to develop.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from PBS, 6% Trehalose, pH 7.4.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein indeionized sterile water to a concentration of 0.1-1.0 mg/mL.Aliquot for long-term storage at -80℃. Solubilize for 60 minutes at room temperature with occasional gentle mixing. Avoid vigorous shaking or vortexing.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事項:
    The VLPs are expressed from human 293 cells (HEK293).Mix the sample gently by repeatedly pipetting it up and down. Do not vortex. Repeated freezing and thawing is not recommended.Store the protein at -20℃/-80℃ upon receiving it, and ensure to avoid repeated freezing and thawing, otherwise, it will affect the protein activity. The immunization strategy should be optimized (antigen dose, regimen and adjuvant).
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    UDP-glucuronosyltransferase (UGT) that catalyzes phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase the metabolite's water solubility, thereby facilitating excretion into either the urine or bile. Essential for the elimination and detoxification of drugs, xenobiotics and endogenous compounds. Catalyzes the glucuronidation of endogenous steroid hormones such as androgens and estrogens. Produces dihydrotestosterone (DHT) diglucuronide from the DHT after two subsequent glucoronidation steps. Also catalyzes the glucuronidation of the isoflavones genistein, daidzein, glycitein, formononetin, biochanin A and prunetin, which are phytoestrogens with anticancer and cardiovascular properties. Involved in the glucuronidation of the AGTR1 angiotensin receptor antagonist caderastan, a drug which can inhibit the effect of angiotensin II. Also metabolizes mycophenolate, an immunosuppressive agent.; Lacks UGT glucuronidation activity but acts as a negative regulator of isoform 1.
  • 基因功能參考文獻:
    1. UGT1A8 gene polymorphisms can affect the activity of UDP glucuronosyltransferase enzyme, which may influence the elimination of mycophenolate mofetil in different patients. PMID: 29025387
    2. Polymorphism of UGT1A8 rs1042597-G variant allele is associated with colorectal cancer. PMID: 29282011
    3. the in vitro glucuronidation of raloxifene in humans and monkeys was examined using liver and intestinal microsomes and recombinant UGT enzymes (UGT1A1, UGT1A8 and UGT1A9). PMID: 26247833
    4. Data suggest UGT1A8 is involved in differential metabolism of dietary flavonoids (glucosides and aglycones); glucuronidation of flavonoid glucosides is considerably slower than glucuronidation of flavonoid aglycones in microsomes of intestine/liver. PMID: 26317684
    5. Genetic polymorphisms of UGT1A8, UGT1A9 and HNF-1alpha and gastrointestinal symptoms in renal transplant recipients taking mycophenolic acid. PMID: 23721685
    6. UGT1A8 Polymorphism is associated with response to raloxifene in breast cancer. PMID: 23682072
    7. A much higher frequency of UGT1A8*2 variant allele was found in Chinese than in Caucasians and Africans PMID: 23700788
    8. The UGT1A8 and UGT2B4 genotypes associated with decreased predicted enzyme activities, were significantly associated with an increased risk of esophageal squamous cell carcinoma. PMID: 22367021
    9. In a study of Japanese renal transplant recipients, there are no significant differences in the area under the plasma concentration-time curve ratio of mycophenolic acid (MPA) glucuronide/MPA between UGT1A8 I399C/T genotypes. PMID: 18695635
    10. Results show UGT1A8 mRNA expression in primary hepatocytes by semi-quantitative RT-PCR. PMID: 17603215
    11. The effect of UGT1A8 and UGT1A9 variants on mycophenolic acid metabolism appears to be modified by concomitant calcineurin inhibitor therapy. PMID: 18568343
    12. the effect of UGT1A8 polymorphism on the pharmacokinetics of mycophenolic acid (MPA) and its metabolites phenolic glucuronide (MPAG) and acyl glucuronide (AcMPAG) in Chinese renal transplant PMID: 18946804

    顯示更多

    收起更多

  • 亞細胞定位:
    Endoplasmic reticulum membrane; Single-pass membrane protein.
  • 蛋白家族:
    UDP-glycosyltransferase family
  • 組織特異性:
    [Isoform 1]: Expressed in kidney, colon and small intestine. Not expressed in liver.; [Isoform 2]: Expressed in liver, kidney, colon and small intestine.
  • 數據庫鏈接:

    HGNC: 12540

    OMIM: 191740

    KEGG: hsa:54576

    STRING: 9606.ENSP00000362549

    UniGene: Hs.554822



主站蜘蛛池模板: 香蕉久久久久久av成人| 首页 综合国产 亚洲 丝袜| 青青国产线免观| 国产xxxxx在线观看| 国内精品久久久久精免费| 精品国产福利久久久| 高清国产在线拍揄自揄视频| 免费极品av一视觉盛宴| 国产成人久久精品二区三区| 级r片内射在线视频播放| 久久久久久人妻一区精品| 中文字幕无码日韩欧免费软件 | 韩国 欧美 日产 国产精品| 在线观看成人无码中文av天堂不卡| 一本久久精品一区二区| 欧美一进一出抽搐大尺度视频| 少妇性l交大片| 午夜私人成年影院| 香蕉97超级碰碰碰视频| 伊人久久久大香线蕉综合直播| 国产男女猛烈无遮挡免费视频| 国产在线观看码高清视频| 三上悠亚精品一区二区久久| 亚洲大码熟女在线观看| 色诱久久久久综合网ywww| 超碰国产精品久久国产精品99| 99国产精品久久久久久久成人| 国产亚洲精品久久yy5099| 国内精品自线在拍2020不卡| 亚洲精品国偷拍自产在线麻豆| 人妻体体内射精一区二区 | 老熟女乱子伦| 亚洲午夜私人影院在线观看| 国产午夜无码片在线观看影视 | 猫咪www免费人成人入口| 精品久久久久久久久中文字幕| 久久精品人人爽人人爽| 青青草国产免费久久久下载| 午夜三级a三级三点窝| 亚洲无人区码一码二码三码的含义| 99热亚洲色精品国产88|