在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Phospholipid phosphatase 1 (PLPP1)

  • 中文名稱:
    人PLPP1重組蛋白
  • 貨號:
    CSB-CF018414HU
  • 規(guī)格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產品詳情

  • 基因名:
  • Uniprot No.:
  • 別名:
    PLPP1; LPP1; PPAP2A; Phospholipid phosphatase 1; Lipid phosphate phosphohydrolase 1; PAP2-alpha; Phosphatidate phosphohydrolase type 2a; Phosphatidic acid phosphatase 2a; PAP-2a; PAP2a
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full length protein
  • 表達區(qū)域:
    1-284
  • 氨基酸序列
    MFDKTRLPYVALDVLCVLLAGLPFAILTSRHTPFQRGVFCNDESIKYPYKEDTIPYALLG GIIIPFSIIVIILGETLSVYCNLLHSNSFIRNNYIATIYKAIGTFLFGAAASQSLTDIAK YSIGRLRPHFLDVCDPDWSKINCSDGYIEYYICRGNAERVKEGRLSFYSGHSSFSMYCML FVALYLQARMKGDWARLLRPTLQFGLVAVSIYVGLSRVSDYKHHWSDVLTGLIQGALVAI LVAVYVSDFFKERTSFKERKEEDSHTTLHETPTTGNHYPSNHQP
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1-phosphate/C1P. Also acts on N-oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound. Through its extracellular phosphatase activity allows both the hydrolysis and the cellular uptake of these bioactive lipid mediators from the milieu, regulating signal transduction in different cellular processes. It is for instance essential for the extracellular hydrolysis of S1P and subsequent conversion into intracellular S1P. Involved in the regulation of inflammation, platelets activation, cell proliferation and migration among other processes. May also have an intracellular activity to regulate phospholipid-mediated signaling pathways.
  • 基因功能參考文獻:
    1. the first of the two transmembrane regions in human SAC1 (TM1) functions in Golgi localization PMID: 23936490
    2. Phosphorylation of lipin 1 and charge on the phosphatidic acid head group control its phosphatidic acid phosphatase activity and membrane association PMID: 23426360
    3. this enzyme regulates interleukin-4-mediated STAT6 signaling. PMID: 12426308
    4. This protein and phosphoprotein SET regulate androgen production by P450c17. PMID: 12444089
    5. lipid phosphate phosphatase-1 has a role in regulating accumulation of lysophosphatidic acid in ovarian cancer PMID: 14506139
    6. Lipopolysaccharide-induced up-regulation of cyclooxygenase-2 depends on the activity of the Mg(+2)-dependent phosphatidic acid phosphohydrolase 1 (PAP-1) PMID: 16950767
    7. LPP1 and LPP3 are distributed in distinct lipid rafts that may provide unique microenvironments defining their non-redundant physiological functions. PMID: 17005594
    8. These results suggest that the expression of PAP2a is directly regulated by p73. PMID: 17169329
    9. These results suggest that LPP1a is important for the determination of plasma FTY720-P levels. PMID: 18755152

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein. Apical cell membrane; Multi-pass membrane protein. Membrane raft; Multi-pass membrane protein. Membrane, caveola; Multi-pass membrane protein.
  • 蛋白家族:
    PA-phosphatase related phosphoesterase family
  • 組織特異性:
    Widely expressed with highest expression found in prostate. Found to be down-regulated in colon adenocarcinomas.; [Isoform 1]: Predominant in kidney, lung, placenta and liver.; [Isoform 2]: Predominant in heart and pancreas.
  • 數據庫鏈接:

    HGNC: 9228

    OMIM: 607124

    KEGG: hsa:8611

    UniGene: Hs.696231



主站蜘蛛池模板: 日韩乱码在线观看免费视频网站 | 国产精品成人99一区无码| 亚洲无线码在线一区观看| 99re热这里只有精品视频| 丰满少妇被粗大的猛烈进出视频| 日本成本人三级在线观看| 国产亚洲精品久久久久久禁果tv| 国产精品专区免费观看软件| 久久亚洲精品成人av| 日本高清视频色wwwwww色| 青青青青国产免费线在线观看| 亚洲精品成人久久电影网| 国产亚洲精品综合一区| 无码一区二区三区亚洲人妻| 欧美人与禽猛交狂配| 国产粗话肉麻对白在线播放| 日韩亚洲国产中文永久| 色悠久久久久综合网国产 | 精品卡一卡二卡3卡高清乱码| 暖暖视频日本在线观看| 国产 高潮 抽搐 正在播放 | 精品国内自产拍在线播放观看| 青椒国产97在线熟女| 欧美午夜精品久久久久免费视| 国产成人av大片大片在线播放| 日韩乱码在线观看免费视频网站 | 欧美乱强伦xxxxx高潮| 成码无人av片在线电影网站| 国产午夜激无码av毛片不卡| 久久www成人_看片免费不卡| 久久俺也去丁香综合色| 好疼太大了太粗太长了视频| 久久久久久九九99精品| 国产99久久久国产精品免费看| 亚洲欧美人高清精品a∨| 国产免费又黄又爽又色毛| 久久久久久亚洲精品中文字幕| 中文字幕av中文字无码亚| 久久精品人人做人人综合试看| 精品乱人伦一区二区三区| 国产精品无码一区二区桃花视频|