在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Hydroxycarboxylic acid receptor 1 (HCAR1)

  • 中文名稱:
    人HCAR1重組蛋白
  • 貨號:
    CSB-CF861159HU
  • 規(guī)格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產(chǎn)品詳情

  • 基因名:
  • Uniprot No.:
  • 別名:
    HCAR1; GPR104; GPR81; HCA1; FKSG80; Hydroxycarboxylic acid receptor 1; G-protein coupled receptor 104; G-protein coupled receptor 81
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    full length protein
  • 表達區(qū)域:
    1-346
  • 氨基酸序列
    MYNGSCCRIEGDTISQVMPPLLIVAFVLGALGNGVALCGFCFHMKTWKPSTVYLFNLAVA DFLLMICLPFRTDYYLRRRHWAFGDIPCRVGLFTLAMNRAGSIVFLTVVAADRYFKVVHP HHAVNTISTRVAAGIVCTLWALVILGTVYLLLENHLCVQETAVSCESFIMESANGWHDIM FQLEFFMPLGIILFCSFKIVWSLRRRQQLARQARMKKATRFIMVVAIVFITCYLPSVSAR LYFLWTVPSSACDPSVHGALHITLSFTYMNSMLDPLVYYFSSPSFPKFYNKLKICSLKPK QPGHSKTQRPEEMPISNLGRRSCISVANSFQSQSDGQWDPHIVEWH
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產(chǎn)品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    Acts as a receptor for L-lactate and mediates its anti-lipolytic effect through a G(i)-protein-mediated pathway.
  • 基因功能參考文獻:
    1. The novel role of HCAR1 in development of chemoresistance in cervical carcinoma HeLa cells via ABCB1 transporter up-regulation. PMID: 29151072
    2. Findings identify GPR81 as a tumor-promoting receptor in breast cancer progression and suggest a novel mechanism that regulates GPR81-dependent activation of the PI3K/Akt signaling axis in tumor microenvironment. PMID: 27765922
    3. Lactate receptor/HCAR1 expression in cervical carcinoma cells may contribute to the modulation of cellular DNA repair mechanisms. PMID: 28258841
    4. HCA1/3 are necessary for breast cancer cells to balance lipid/fatty acid metabolism. PMID: 25839160
    5. HCAR1 and monocarboxylate transporters activity is required for the L- and D-lactate-mediated enhancement of DNA repair and of HeLa cell survival. PMID: 26208712
    6. Description of a GPR81 selective agonist with in vivo efficacy, inhibiting lipolysis without flushing. PMID: 24486398
    7. Data support that GPR81 is important for cancer cell regulation of lactate transport mechanisms. PMID: 24928781
    8. Lactate negatively regulates TLR induction of the NLRP3 inflammasome and production of IL1beta, via ARRB2 and GPR81 in liver and pancreatic injury. PMID: 24657625
    9. demonstrated that the C165-E166-S167-F168 motif at the second extracellular loop is critical for GPR81 function, and the conserved six Cys residues at the extracellular regions are necessary for GPR81 function PMID: 21862690
    10. GPR81 with relatively restricted expression in the adipose tissues functions as a receptor for lactate and can mediate an anti-lipolytic effect of lactate. PMID: 18952058
    11. Data show that the coordinated PPARgamma-mediated regulation of the GPR81, GPR109A and GPR109B presents a novel mechanism by which TZDs may reduce circulating free fatty acid levels and perhaps ameliorate insulin resistance in obese patients. PMID: 19633298

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 1 family
  • 組織特異性:
    Expressed abundantly in brown and white fat. It also detectable at lower levels in liver, kidney, skeletal muscle, brain and pituitary. Not detected in frontal, temporal and occipital lobes of the cortex, basal forebrain, caudate nucleus, nucleus accumben
  • 數(shù)據(jù)庫鏈接:

    HGNC: 4532

    OMIM: 606923

    KEGG: hsa:27198

    STRING: 9606.ENSP00000349478

    UniGene: Hs.610873



主站蜘蛛池模板: 国产午夜永久福利视频在线观看| 精品人妻中文字幕有码在线| 99久久久无码国产精品古装| 国产九九99久久99大香伊| 一本精品99久久精品77| 国产欧美国日产高清| 超碰免费公开| 男男啪啪激烈高潮cc漫画免费| 狠狠色综合网站久久久久久久高清| 国产高潮抽搐喷水高清| 国产福利酱国产一区二区| 亚洲hdmi高清线| 欧美日韩亚洲国内综合网 | 亚洲欧洲日产韩国在线看片| 亚洲精品久久久久国产剧8| 精品人妻va出轨中文字幕| 亚洲国产精品热久久| 国产精品久免费的黄网站| 精品毛片乱码1区2区3区| 国产a v高清一区二区三区| 2022国产成人精品视频人| 久久国产avjust麻豆| 国产嘿嘿嘿视频在线观看| 久久久久影院美女国产主播| 欧美午夜精品一区二区蜜桃| 宅宅少妇无码| 8av国产精品爽爽ⅴa在线观看| 中文字幕精品视频在线看免费| 丰满的少妇hd高清中文字幕| 人妻少妇中文字幕乱码| 欧美大屁股xxxx高跟欧美黑人| 成人影院yy111111在线| 92精品成人国产在线观看| 精品无码久久久久久久动漫| 18禁网站免费无遮挡无码中文| 肉大捧一进一出免费视频| 亚洲一线产区二线产区分布| 男女18禁啪啪无遮挡| 国产成人无码免费看片软件| 天天爽夜夜爽人人爽从早干到睌| 亚洲精品伊人久久久大香|