在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Hydroxycarboxylic acid receptor 1 (HCAR1), partial

  • 中文名稱:
    人HCAR1重組蛋白
  • 貨號:
    CSB-YP861159HU1
  • 規(guī)格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人HCAR1重組蛋白
  • 貨號:
    CSB-EP861159HU1
  • 規(guī)格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人HCAR1重組蛋白
  • 貨號:
    CSB-EP861159HU1-B
  • 規(guī)格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人HCAR1重組蛋白
  • 貨號:
    CSB-BP861159HU1
  • 規(guī)格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人HCAR1重組蛋白
  • 貨號:
    CSB-MP861159HU1
  • 規(guī)格:
  • 來源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    HCAR1; GPR104; GPR81; HCA1; FKSG80; Hydroxycarboxylic acid receptor 1; G-protein coupled receptor 104; G-protein coupled receptor 81
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial
  • 蛋白標(biāo)簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能:
    Acts as a receptor for L-lactate and mediates its anti-lipolytic effect through a G(i)-protein-mediated pathway.
  • 基因功能參考文獻(xiàn):
    1. The novel role of HCAR1 in development of chemoresistance in cervical carcinoma HeLa cells via ABCB1 transporter up-regulation. PMID: 29151072
    2. Findings identify GPR81 as a tumor-promoting receptor in breast cancer progression and suggest a novel mechanism that regulates GPR81-dependent activation of the PI3K/Akt signaling axis in tumor microenvironment. PMID: 27765922
    3. Lactate receptor/HCAR1 expression in cervical carcinoma cells may contribute to the modulation of cellular DNA repair mechanisms. PMID: 28258841
    4. HCA1/3 are necessary for breast cancer cells to balance lipid/fatty acid metabolism. PMID: 25839160
    5. HCAR1 and monocarboxylate transporters activity is required for the L- and D-lactate-mediated enhancement of DNA repair and of HeLa cell survival. PMID: 26208712
    6. Description of a GPR81 selective agonist with in vivo efficacy, inhibiting lipolysis without flushing. PMID: 24486398
    7. Data support that GPR81 is important for cancer cell regulation of lactate transport mechanisms. PMID: 24928781
    8. Lactate negatively regulates TLR induction of the NLRP3 inflammasome and production of IL1beta, via ARRB2 and GPR81 in liver and pancreatic injury. PMID: 24657625
    9. demonstrated that the C165-E166-S167-F168 motif at the second extracellular loop is critical for GPR81 function, and the conserved six Cys residues at the extracellular regions are necessary for GPR81 function PMID: 21862690
    10. GPR81 with relatively restricted expression in the adipose tissues functions as a receptor for lactate and can mediate an anti-lipolytic effect of lactate. PMID: 18952058
    11. Data show that the coordinated PPARgamma-mediated regulation of the GPR81, GPR109A and GPR109B presents a novel mechanism by which TZDs may reduce circulating free fatty acid levels and perhaps ameliorate insulin resistance in obese patients. PMID: 19633298

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 1 family
  • 組織特異性:
    Expressed abundantly in brown and white fat. It also detectable at lower levels in liver, kidney, skeletal muscle, brain and pituitary. Not detected in frontal, temporal and occipital lobes of the cortex, basal forebrain, caudate nucleus, nucleus accumben
  • 數(shù)據(jù)庫鏈接:

    HGNC: 4532

    OMIM: 606923

    KEGG: hsa:27198

    STRING: 9606.ENSP00000349478

    UniGene: Hs.610873



主站蜘蛛池模板: 国内精品伊人久久久久妇| 在线高清亚洲精品二区| 免费人成在线观看成人片| 久久99er精品国产首页| 国产裸拍裸体视频在线观看| 亚洲欧美丝袜精品久久| 国产+日韩+另类+视频一区| 国产亚洲另类无码专区| 欧美日本免费一区二区三区| 五月花成人网| 欧美人牲口杂交在线播放免费| 婷婷五月婷婷五月| 天天做天天爱天天要天天| 亚洲精品伊人久久久大香| 播放灌醉水嫩大学生国内精品 | 久久香蕉国产线看观看手机| 亚洲日本乱码一区二区产线一∨| 亚洲日韩国产精品第一页一区| 亚洲精品无码久久久久| 边吃奶边添下面好爽| 亚洲精品乱码一区二区三区| 日韩吃奶摸下aa片免费观看| 男ji大巴进入女人的视频| 亚洲综合色区无码专区| 人妻无码中文字幕永久在线| 日日碰狠狠躁久久躁| 日韩精品a片一区二区三区妖精| 日日橹狠狠爱欧美视频| 无码少妇一区二区三区视频| 国内精品伊人久久久久影院麻豆 | 无码人妻精品一区二区蜜桃百度 | 久久精品国产久精国产| 色噜噜狠狠色综合成人网| 性色高清xxxxx厕所偷窥| 亚洲高清国产拍精品闺蜜合租| 性欧美高清come| 麻豆精产一二三产区| 久久综合给合久久狠狠97色| 爽爽影院免费观看| 中文字幕人妻无码专区| 在线观看片免费人成视频无码|