在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human C-C chemokine receptor-like 2 (CCRL2)-VLPs

  • 中文名稱:
    Recombinant Human C-C chemokine receptor-like 2 (CCRL2)-VLPs
  • 貨號:
    CSB-MP004852HU
  • 規格:
  • 其他:

產品詳情

  • 基因名:
  • Uniprot No.:
  • 別名:
    (Chemokine receptor CCR11)(Chemokine receptor X)(Putative MCP-1 chemokine receptor)
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length
  • 來源:
    Mammalian cell
  • 表達區域:
    1-344aa
  • 氨基酸序列
    MANYTLAPEDEYDVLIEGELESDEAEQCDKYDAQALSAQLVPSLCSAVFVIGVLDNLLVVLILVKYKGLKRVENIYLLNLAVSNLCFLLTLPFWAHAGGDPMCKILIGLYFVGLYSETFFNCLLTVQRYLVFLHKGNFFSARRRVPCGIITSVLAWVTAILATLPEFVVYKPQMEDQKYKCAFSRTPFLPADETFWKHFLTLKMNISVLVLPLFIFTFLYVQMRKTLRFREQRYSLFKLVFAIMVVFLLMWAPYNIAFFLSTFKEHFSLSDCKSSYNLDKSVHITKLIATTHCCINPLLYAFLDGTFSKYLCRCFHLRSNTPLQPRGQSAQGTSREEPDHSTEV
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    C-terminal 10xHis-tagged
    If you have specified tag type, please tell us and we will check if it's possible to develop.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from PBS, 6% Trehalose, pH 7.4.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein indeionized sterile water to a concentration of 0.1-1.0 mg/mL.Aliquot for long-term storage at -80℃. Solubilize for 60 minutes at room temperature with occasional gentle mixing. Avoid vigorous shaking or vortexing.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事項:
    The VLPs are expressed from human 293 cells (HEK293).Mix the sample gently by repeatedly pipetting it up and down. Do not vortex. Repeated freezing and thawing is not recommended.Store the protein at -20℃/-80℃ upon receiving it, and ensure to avoid repeated freezing and thawing, otherwise, it will affect the protein activity. The immunization strategy should be optimized (antigen dose, regimen and adjuvant).
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Receptor for CCL19 and chemerin/RARRES2. Does not appear to be a signaling receptor, but may have a role in modulating chemokine-triggered immune responses by capturing and internalizing CCL19 or by presenting RARRES2 ligand to CMKLR1, a functional signaling receptors. Plays a critical role for the development of Th2 responses.
  • 基因功能參考文獻:
    1. CCRL2 mRNA was not significantly changed in murine and human non-alcoholic steatohepatitis liver. CCRL2 mRNA levels were positively correlated with inflammation, fibrosis and NASH scores in the patients. PMID: 28600126
    2. CCRL2 inhibited the growth of breast cancer cells in vitro and in vivo. PMID: 26487662
    3. in breast cancer, CRAM-A becomes specifically upregulated under inflammatory stimuli and may serve as a potential marker of immune response. PMID: 26563945
    4. these results suggest for the first time that elevated CCRL2 in glioma promotes cell migration and invasion. PMID: 23142225
    5. Considering the newly defined role of CCRL2 in lung dendritic cell trafficking, this atypical chemokine receptor may affect pneumocystis pneumonia through immune regulation and inducing inflammation. PMID: 22046140
    6. demonstration that the homeostatic chemokine CCL19 is a specific ligand for CRAM PMID: 20002784
    7. CCRL2 expression is up-regulated on synovial neutrophils of rheumatoid arthritis patients PMID: 15188357
    8. Results identify chemerin as a natural nonsignaling protein ligand for both human and mouse CCRL2. PMID: 18794339

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 1 family
  • 組織特異性:
    Expressed abundantly in immunal tissues such as spleen, fetal liver, lymph node and bone marrow. Strong expression also in lung and heart. Expressed in almost all hematopoietic cells including monocytes, macrophages, PMNs, T-cells (both CD4+ and CD8+), mo
  • 數據庫鏈接:

    HGNC: 1612

    OMIM: 608379

    KEGG: hsa:9034

    STRING: 9606.ENSP00000349967

    UniGene: Hs.535713



主站蜘蛛池模板: 又粗又硬又大又爽免费视频播放| 无码a∨高潮抽搐流白浆| 欧美亚洲日本高清不卡| 亚洲婷婷综合色高清在线| 手机在线看片| 中文字幕人妻被公上司喝醉 | a欧美爰片久久毛片a片| 欧洲av无码放荡人妇网站| 中文字幕色av一区二区三区| 亚洲精品天天影视综合网| 少妇被粗大的猛进出69影院| 久9热视频这里只精品18| 熟女人妻大叫粗大受不了| 一本丁香综合久久久久不卡网站| 国产xxx视频在线观看软件| 亚洲欭美日韩颜射在线| 成人性能视频在线| 国产亚洲视频在线观看播放| 国产美女露脸口爆吞精| 色吊丝中文字幕| 国产精品久久久久av福利动漫| 亚洲2021av天堂手机版| 精品久久久久中文字幕app| 无码国产69精品久久久孕妇| 国产欧美久久一区二区三区| 国产在线看片免费观看| 国产精品专区免费观看软件| 伊人色综合一区二区三区| 性欧美性另类巨大| 亚洲高清国产拍精品26u| 欧美丰满老熟妇aaaa片| 中文字幕无码不卡免费视频| 国产精品69人妻无码久久 | 少妇的肉体在线观看| 国精品无码一区二区三区在线蜜臀| 国产成人欧美日本在线观看| 成人午夜亚洲精品无码区| 一本一道波多野结衣av一区| 亚洲国产一区二区三区在观看| 亚洲伊人色欲综合网无码中文| 亚洲午夜成人片|