在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Bombesin receptor subtype-3 (BRS3)

  • 中文名稱:
    Recombinant Human Bombesin receptor subtype-3(BRS3)
  • 貨號:
    CSB-CF002820HU
  • 規格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產品詳情

  • 基因名:
  • Uniprot No.:
  • 別名:
    BRS3; Bombesin receptor subtype-3; BRS-3
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full length protein
  • 表達區域:
    1-399
  • 氨基酸序列
    MAQRQPHSPNQTLISITNDTESSSSVVSNDNTNKGWSGDNSPGIEALCAIYITYAVIISV GILGNAILIKVFFKTKSMQTVPNIFITSLAFGDLLLLLTCVPVDATHYLAEGWLFGRIGC KVLSFIRLTSVGVSVFTLTILSADRYKAVVKPLERQPSNAILKTCVKAGCVWIVSMIFAL PEAIFSNVYTFRDPNKNMTFESCTSYPVSKKLLQEIHSLLCFLVFYIIPLSIISVYYSLI ARTLYKSTLNIPTEEQSHARKQIESRKRIARTVLVLVALFALCWLPNHLLYLYHSFTSQT YVDPSAMHFIFTIFSRVLAFSNSCVNPFALYWLSKSFQKHFKAQLFCCKAERPEPPVADT SLTTLAVMGTVPGTGSIQMSEISVTSFTGCSVKQAEDRF
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Role in sperm cell division, maturation, or function. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.
  • 基因功能參考文獻:
    1. These results suggest that human BRS-3, similar to GRPR/NMBR, is frequently ectopically-expressed by lung-cancer cells in which, it is functional, affecting cell signaling/growth. PMID: 29410320
    2. mammalian homologue of CCHa2-R, Bombesin receptor subtype-3 (Brs3), is an orphan receptor that is expressed in the islet beta-cells PMID: 26020940
    3. High BRS3 expression is associated with liver metastases of pancreas neuroendocrine tumors. PMID: 25241033
    4. The role of the human BRS-3 receptor in glucose homeostasis. PMID: 24220502
    5. Data show that gastrin-releasing peptide receptor/bombesin receptor subtype-3 positive cells and protein expression in tumors decreased by treatment with RC-3095 or gemcitabine alone or greater in combination. PMID: 24326363
    6. BRS-3 plays an important role in glucose metabolism. PMID: 23291341
    7. BRS-3 agonist-dependent signaling mediates CREB phosphorylation and transactivation through protein kinase (PK)A, (PK)C, and mitogen-activated protein/extracellular regulated kinase kinase (MEK)-1 pathways. PMID: 22127929
    8. These results identify a potential role for BRS-3 in islet physiology, with agonism directly promoting glucose-stimulated insulin secretion PMID: 21878513
    9. results indicate that the sequence variation in the E3 loop is responsible for the species difference between rat and human BRS-3, and multiple residues in the E3 loop are involved in interactions with the agonist dY-bombesin PMID: 12102638
    10. Study found that the BRS-3 agonist stimulated adhesion of NCI-N417 cells in laminin-coated culture wells suggesting that BRS-3 may be involved in invasion and metastasis of certain cancer cells PMID: 16979789
    11. Data suggest that activator protein 2alpha and peroxisome-proliferator-activated receptor alpha may be especially involved in the ozone-inducible up-regulation mechanism of bombesin receptor subtype 3 expression. PMID: 17355223
    12. The secretion of TGF-beta1 increased and the synthesis of PGE2 decreased from BRS-3-activated BEC, which were correlated with the proliferation and collagen synthesis of HLF. PMID: 17714959

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 1 family
  • 組織特異性:
    In germ cells in testis. Lung carcinoma cells.
  • 數據庫鏈接:

    HGNC: 1113

    OMIM: 300107

    KEGG: hsa:680

    STRING: 9606.ENSP00000359682

    UniGene: Hs.121484



主站蜘蛛池模板: 免费国产高清毛不卡片基地| 国产成人8x人网站视频| 国产亚洲精品久久久久久青梅| 奇米综合四色77777久久| 少妇激情一区二区三区视频小说 | 国产精品美脚玉足脚交| 北条麻妃一区二区三区av高清| 亚洲中文字幕无码av在线| 99久久国产露脸精品| 国产成人av免费观看| 无套内谢的新婚少妇国语播放| 欧美日韩无线码在线观看| 天堂在线www资源在线| 亚洲成a人片在线观看无码下载 | 人妻无码手机在线中文| 女人被狂躁c到高潮喷水电影| 任你躁x7x7x7x7在线观看| 欧美黑人激情性久久| 中文字幕无码专区人妻系列| 精品国产免费一区二区三区香蕉| 99久久久无码国产精品9| 久欠精品国国产99国产精2021| 99蜜桃臀久久久欧美精品网站| 久久av无码αv高潮αv喷吹| 精选国产av精选一区二区三区 | 日本va欧美va欧美va精品| 性亚洲videofree高清| 日韩a毛片免费观看| 日本丰满妇人成熟免费中文字幕 | 国产精品一区二区无线| 午夜dy888国产精品影院| 大j8黑人w巨大888a片| 欧美极品少妇性运交| 精品久久久久久成人av| 偷国产乱人伦偷精品视频| 国产免费高清69式视频在线观看| 天堂а√中文在线| 亚洲第一成年免费网站| 亚洲精品蜜桃久久久久久| 人人妻人人玩人人澡人人爽| 中文字幕久久精品波多野结百度 |