在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human 2-hydroxyacylsphingosine 1-beta-galactosyltransferase (UGT8)

  • 中文名稱:
    人UGT8重組蛋白
  • 貨號:
    CSB-CF618101HU
  • 規格:
  • 來源:
    in vitro E.coli expression system
  • 其他:

產品詳情

  • 基因名:
    UGT8
  • Uniprot No.:
  • 別名:
    UGT8; CGT; UGT4; 2-hydroxyacylsphingosine 1-beta-galactosyltransferase; Ceramide UDP-galactosyltransferase; Cerebroside synthase; UDP-galactose-ceramide galactosyltransferase
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區域:
    21-541
  • 氨基酸序列
    AKIIIVPPIMFESHMYIFKTLASALHERGHHTVFLLSEGRDIAPSNHYSLQRYPGIFNST TSDAFLQSKMRNIFSGRLTAIELFDILDHYTKNCDLMVGNHALIQGLKKEKFDLLLVDPN DMCGFVIAHLLGVKYAVFSTGLWYPAEVGAPAPLAYVPEFNSLLTDRMNLLQRMKNTGVY LISRLGVSFLVLPKYERIMQKYNLLPEKSMYDLVHGSSLWMLCTDVALEFPRPTLPNVVY VGGILTKPASPLPEDLQRWVNGANEHGFVLVSFGAGVKYLSEDIANKLAGALGRLPQKVI WRFSGPKPKNLGNNTKLIEWLPQNDLLGHSKIKAFLSHGGLNSIFETIYHGVPVVGIPLF GDHYDTMTRVQAKGMGILLEWKTVTEKELYEALVKVINNPSYRQRAQKLSEIHKDQPGHP VNRTIYWIDYIIRHNGAHHLRAAVHQISFCQYFLLDIAFVLLLGAALLYFLLSWVTKFIY RKIKSLWSRNKHSTVNGHYHNGILNGKYKRNGHIKHEKKVK
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Lyophilized from Tris/PBS-based buffer, 6% Trehalose, pH 8.0
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system. Galactosylates both hydroxy- and non-hydroxy fatty acid-containing ceramides and diglycerides.
  • 基因功能參考文獻:
    1. An increase in the immunolabelling of ceramide was observed in cells where UDP glycosyltransferase 8 (UGT8) was down-regulated as opposed to cells where UGT8 was either not regulated or was up-regulated. PMID: 28746357
    2. Data indicate that ceramide galactosyltransferase (UGT8), although enhanced in non-small cell lung carcinoma (NSCLC) tissues, does not meet the criteria of a lung tumor marker. PMID: 27620310
    3. Our study suggests that CGT expression is controlled by balanced expression of the negative modulator OLIG2 and positive regulator Nkx2.2, providing new insights into how expression of GalCer is tightly regulated in cell-type- and stage-specific manners. PMID: 24821492
    4. A new role was identified for UGT8 as a modulator of bile acid homeostasis. PMID: 25519837
    5. High expression of UGT8 accompanied by accumulation of GalCer in MDA-MB-231 cells is associated with a much higher proliferative index and a lower number of apoptotic cells in comparison to the MDA/LUC-shUGT8 cells. PMID: 24391908
    6. Comprehensive genomic analyses associate UGT8 variants with musical ability in a Mongolian population. PMID: 23118445
    7. UGT8 is a significant index of tumour aggressiveness and is seen in lung metastases of breast cancer. PMID: 20648017
    8. Single-nucleotide polymorphisms (SNPs) were found in UGT8 gene PMID: 12376738
    9. the GC-box and CRE function cooperatively, and that the CRE regulates the cell-specific expression of the hCGT gene PMID: 15229398
    10. We postulate that molecular link between defective GALT enzyme, which result in classic galactosemia and the cerebroside galactosyl transferase, responsible for galactosylation of cerebrosides, is dependent on concentrations of UDP-galactose. PMID: 16125333
    11. Gene expression of galactosyl ceramide synthase associated with poor pathohistological grading in breast cancer PMID: 19125296

    顯示更多

    收起更多

  • 亞細胞定位:
    Membrane; Single-pass membrane protein. Endoplasmic reticulum.
  • 蛋白家族:
    UDP-glycosyltransferase family
  • 數據庫鏈接:

    HGNC: 12555

    OMIM: 601291

    KEGG: hsa:7368

    STRING: 9606.ENSP00000311648

    UniGene: Hs.144197



主站蜘蛛池模板: 色翁荡息又大又硬又粗又爽| 久久久精品人妻无码专区不卡| 亚洲精品乱码久久久久久久久久久久| 欧美一夜爽爽爽爽爽爽| 青青草国产精品免费观看| 国产成人a在线观看视频| 国产在线视频一区二区三区| 后入到高潮免费观看| 女人与拘性猛交视频| 久久99精品久久久久久齐齐| 国产成人精品无码一区二区三区| 免费午夜福利不卡片在线播放| 成人精品一区日本无码网| 337p日本欧洲亚洲大胆色噜噜| 99久久精品国产成人综合 | 久久久亚洲色| 亚洲综合一区国产精品| 99久久精品6在线播放| 久久精品蜜芽亚洲国产av| 亚无码乱人伦一区二区| 久久66热人妻偷产精品| 人体内射精一区二区三区| 亚洲大尺度无码无码专线一区| 在线人人车操人人看视频| 亚洲h成年动漫在线观看网站| 日本又黄又爽gif动态图| 国产免费无遮挡吸乳视频| 日韩精品一卡2卡三卡4卡| 成人无遮挡18禁免费视频| 无码国产色欲xxxxx视频| 午夜理论片yy44880影院| 男插女高潮一区二区| aⅴ亚洲 日韩 色 图网站 播放| 性xxxx搡xxxxx搡欧美| 日产日韩亚洲欧美综合下载| 亚洲欧美日韩国产自偷| 一进一出抽搐gif| 久久www色情成人免费| 欧洲美熟女乱又伦av| 精品人妻系列无码一区二区三区| 精品人妻系列无码人妻不卡|