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  4. Recombinant Sheep Serotonin N-acetyltransferase (AANAT)

Recombinant Sheep Serotonin N-acetyltransferase (AANAT)

  • 中文名稱：
    Recombinant Sheep Serotonin N-acetyltransferase(AANAT)
  • 貨號：
    CSB-YP641837SH
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Sheep Serotonin N-acetyltransferase(AANAT)
  • 貨號：
    CSB-EP641837SH
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Sheep Serotonin N-acetyltransferase(AANAT)
  • 貨號：
    CSB-EP641837SH-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Sheep Serotonin N-acetyltransferase(AANAT)
  • 貨號：
    CSB-BP641837SH
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Sheep Serotonin N-acetyltransferase(AANAT)
  • 貨號：
    CSB-MP641837SH
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    AANAT
  • Uniprot No.：
  • 別名：
    AANAT; SNAT; Serotonin N-acetyltransferase; Serotonin acetylase; EC 2.3.1.87; Aralkylamine N-acetyltransferase; AA-NAT
  • 種屬：
    Ovis aries (Sheep)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-207
  • 氨基酸序列
    MSTPSVHCLK PSPLHLPSGI PGSPGRQRRH TLPANEFRCL TPEDAAGVFE IEREAFISVS GNCPLNLDEV QHFLTLCPEL SLGWFVEGRL VAFIIGSLWD EERLTQESLA LHRPRGHSAH LHALAVHRSF RQQGKGSVLL WRYLHHVGAQ PAVRRAVLMC EDALVPFYQR FGFHPAGPCA IVVGSLTFTE MHCSLRGHAA LRRNSDR
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin.
  • 基因功能參考文獻：
    1. Our study proves that IL-1beta suppresses melatonin secretion and its action seems to be targeted on the reduction of pineal AA-NAT protein expression PMID: 26339621
    2. These results support that serotonin N-Acetyltransferase phosphorylation is not sufficient for complex formation with 14-3-3, as structurally constrained anchor residues play a critical function in stabilizing the protein-protein interaction. PMID: 21216250
    3. structural kink and local rigidity imposed by Pro-64 may enhance activity by favoring configurations of Loop 1 that facilitate catalysis and do not become immobilized by intramolecular interactions PMID: 18362150
  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    Acetyltransferase family, AANAT subfamily
  • 組織特異性：
    Highest expression in the pineal gland, followed by retina. Expressed at much lower levels in brainstem and pituitary gland. AANAT activity also detected at low levels in the olfactory lobe.
  • 數據庫鏈接：

    KEGG: oas:443531

    UniGene: Oar.638



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