在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Saccharomyces cerevisiae GTP-binding protein YPT1 (YPT1)

Recombinant Saccharomyces cerevisiae GTP-binding protein YPT1 (YPT1)

  • 中文名稱：
    釀酒酵母YPT1重組蛋白
  • 貨號：
    CSB-BP360492SVG
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    釀酒酵母YPT1重組蛋白
  • 貨號：
    CSB-EP360492SVG-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    釀酒酵母YPT1重組蛋白
  • 貨號：
    CSB-MP360492SVG
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
    Name:YPT1 Synonyms:YP2 Ordered Locus Names:YFL038C
  • Uniprot No.：
  • 別名：
    YPT1; YP2; YFL038C; GTP-binding protein YPT1; Protein YP2; Rab GTPase YPT1; Transport GTPase YPT1
  • 種屬：
    Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-206
  • 氨基酸序列
    MNSEYDYLFK LLLIGNSGVG KSCLLLRFSD DTYTNDYIST IGVDFKIKTV ELDGKTVKLQ IWDTAGQERF RTITSSYYRG SHGIIIVYDV TDQESFNGVK MWLQEIDRYA TSTVLKLLVG NKCDLKDKRV VEYDVAKEFA DANKMPFLET SALDSTNVED AFLTMARQIK ESMSQQNLNE TTQKKEDKGN VNLKGQSLTN TGGGCC
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. YPT1 regulates the trafficking of secretory vesicles from the endoplasmic reticulum (ER) to the Golgi. Vesicular transport depends on shuttling of YPT1 between membrane and cytosol by GDI1, probably by recycling it to its membrane of origin after a vesicle fusion event. Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum. Also involved in the recycling of membrane proteins.
  • 基因功能參考文獻：
    1. TRAPPIII and Ypt1 control membrane trafficking events under normal growth conditions and during autophagy. PMID: 29109089
    2. Since these there proteinases belong to the CPY pathway, YPT1 is even believed to up-regulate this trafficking pathway in yeast cells. Future studies, however, should be carried out to discover the mechanisms that allow YPT1 to recruit these proteins into yeast vacuoles PMID: 26895320
    3. that changes in Ypt1 and Ypt31 activity affect Golgi cisternal progression, early-to-transitional and transitional-to-late, respectively PMID: 26906739
    4. Ypt1 binds and activates Hrr25 to spatially regulate its kinase activity. PMID: 26195667
    5. Finally, three sequential steps of this pathway are delineated: Atg9-dependent exit from the ER en route to autophagy, Ypt1- and core Atgs-mediated pre-autophagsomal-structure organization, and Ypt51-mediated delivery of APs to the vacuole PMID: 26181331
    6. results suggest that Ypt1p is involved in the cellular protection process under heat stress conditions PMID: 26169936
    7. These findings establish a role for an autophagy-specific Ypt1 module in the regulation of ER-phagy. Moreover, because Ypt1 is a known key regulator of ER-to-Golgi transport, these findings establish a second role for Ypt1 at the ER PMID: 23924895
    8. Findings show that Ypt1/Rab1 infindings show that Ypt1/Rab1 interacts with Atg1/Ulk1 in yeast and mammalian cells. PMID: 23716696
    9. Trs85 and Ypt1 are localized to the preautophagosomal structure in an Atg9-dependent manner. PMID: 23129774
    10. Our findings establish that Ypt1 contributes to regulation of UPR signaling dynamics by promoting the decay of HAC1 RNA, suggesting a potential regulatory mechanism for linking vesicle trafficking to the UPR and ER homeostasis PMID: 22844259
    11. Ypt1 and Atg11 colocalize with Trs85, a Ypt1 activator subunit, and together they regulate selective autophagy. PMID: 22509044
    12. Ypt1 is essential for autophagy. PMID: 20375281
    13. alpha-Synuclein expression blocks ER-to-Golgi vesicular trafficking; in a genomewide screen, the largest class of toxicity modifiers were proteins functioning at this step including Ypt1p which associated with cytoplasmic alphaSyn inclusions PMID: 16794039
    14. These results show that Trs65 plays a role in the Ypt guanine nucleotide exchanger activity of TRAPP II in concert with the two other TRAPP II-specific subunits. PMID: 17475775
    15. These results confirm the link between translation and vesicular trafficking and reinforce the implication of eIF5A in protein synthesis. PMID: 18568365
    16. Study presents the structure of a heteropentameric TRAPPI assembly complexed with Ypt1p & leads to proposal for mechanism for guanine nucleotide exchange in which each subunit in the TRAPPI subassembly contributes to the activity of this multimer. PMID: 18585354
    17. identify the kinetic and thermodynamic bases by which TRAPP catalyzes nucleotide exchange from Ypt1p PMID: 19361519
    18. Data show that Gyp1p, a GAP for Ypt1p, specifically interacts with Ypt32p, and that this interaction is important for the localization and stability of Gyp1p. PMID: 19666511

    顯示更多

    收起更多

  • 亞細胞定位：
    Endoplasmic reticulum membrane; Peripheral membrane protein. Golgi apparatus membrane; Peripheral membrane protein. Cytoplasm. Preautophagosomal structure membrane; Lipid-anchor; Cytoplasmic side. Note=ER and Golgi when GTP-bound. Cytoplasmic when bound to GDI1.
  • 蛋白家族：
    Small GTPase superfamily, Rab family
  • 數據庫鏈接：

    KEGG: sce:YFL038C

    STRING: 4932.YFL038C



主站蜘蛛池模板： 久久久久久久久888| 18成禁人视频免费| 精品无码国产日韩制服丝袜 | 丰满人妻在公车被猛烈进入电影| 99久久久国产精品无码免费| 丝袜无码一区二区三区| 中国china体内裑精亚洲日本| 久久精品人妻中文系列| 高潮毛片无遮挡高清免费| 情欲少妇人妻100篇| 日本熟妇hdsex视频| 最新精品国偷自产在线美女足| 少妇无码av无码专区在线观看| 国产午夜大地久久| 国产经典三级av在线播放| 三级男人添奶爽爽爽视频| 亚洲人亚洲精品成人网站| 欧美亚洲国产精品久久蜜芽| 国产肉丝袜视频在线观看| 人与性动交aaaabbbb| 免费特级毛片| 人妻出轨av中文字幕| 国产精品门事件av| 无码国产色欲xxxx视频| 欧美日韩免费专区在线| 精品无人区麻豆乱码1区2区| 国产 亚洲 制服 无码 中文| 丰满少妇女裸体bbw| 日本十八禁黄无遮禁视频免费| 国产精品禁18久久久夂久| 色偷偷亚洲男人本色| 欧美亚洲综合成人a∨在线| 久久久一本精品久久精品六六| 内射精品无码中文字幕| 日本新janpanese乱熟| 久久久久久无码日韩欧美| 曰批视频免费30分钟成人| 精品久久久久久久久久中文字幕| 中文字幕日产熟女乱码| 国产麻豆精品福利在线观看| 18禁高潮出水呻吟娇喘蜜芽|