在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Saccharomyces cerevisiae APC/C activator protein CDC20 (CDC20), partial

  • 中文名稱:
    Recombinant Saccharomyces cerevisiae APC/C activator protein CDC20(CDC20) ,partial
  • 貨號:
    CSB-YP335189SVG
  • 規(guī)格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Saccharomyces cerevisiae APC/C activator protein CDC20(CDC20) ,partial
  • 貨號:
    CSB-EP335189SVG
  • 規(guī)格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    Recombinant Saccharomyces cerevisiae APC/C activator protein CDC20(CDC20) ,partial
  • 貨號:
    CSB-EP335189SVG-B
  • 規(guī)格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Saccharomyces cerevisiae APC/C activator protein CDC20(CDC20) ,partial
  • 貨號:
    CSB-BP335189SVG
  • 規(guī)格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Saccharomyces cerevisiae APC/C activator protein CDC20(CDC20) ,partial
  • 貨號:
    CSB-MP335189SVG
  • 規(guī)格:
  • 來源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    CDC20; YGL116WAPC/C activator protein CDC20; Cell division control protein 20
  • 種屬:
    Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    Activator protein that regulates the ubiquitin ligase activity and substrate specificity of the anaphase promoting complex/cyclosome (APC/C). At the metaphase-to-anaphase transition, recognizes and binds proteins containing a D-box including the B-type cyclins CLB2 and CLB5, HSL1 and securin PDS1, and recruits them in a C-box-dependent manner to the APC/C for ubiquitination and subsequent proteolysis. Required for sister chromatid separation and disassembly of the mitotic spindle. Target of the spindle checkpoint pathway through participation in the mitotic checkpoint complex (MCC) and the MAD2-CDC20 subcomplex. MCC and presumably the MAD2-CDC20 subcomplex inhibit the ubiquitin ligase activity of the anaphase promoting complex/cyclosome (APC/C) by preventing its activation by CDC20 until proper attachment of all chromosomes to the spindle.
  • 基因功能參考文獻:
    1. Small N-terminal regions of both Cdc20 (RxxL-type D box) and Cdc5 (KEN motif) were identified as transferable degradation domains (degrons) that mediated efficient targeting by APC/C-Cdh1 (anaphase-promoting complex/cyclosome-Cdh1). PMID: 25540434
    2. Bub3 has a previously unknown function at the kinetochore in activating APC/C-Cdc20 for normal mitotic progression. PMID: 25987604
    3. Both catalysis of Mad1:C-Mad2 at the kinetochores and Mad2-Cdc20 binding away from kinetochores are required for a proficient checkpoint. PMID: 23000150
    4. study analyzed the role of Cdc20 autoubiquitination in the spindle assembly checkpoint PMID: 22940250
    5. This study finds that the majority of Cdc20 turnover does not involve a second activator molecule but instead depends on in cis Cdc20 autoubiquitination while it is bound to its activator-binding site on the anaphase-promoting complex (APC) core. PMID: 22079111
    6. Mad3 is required for the stable binding of Mad2 to Cdc20 in vivo, which is sufficient to inhibit APC activity and is the most downstream event in spindle checkpoint activation. PMID: 22209528
    7. data suggest important roles of ubiquitination in mediating IGF-1R signaling and degradation PMID: 17406666
    8. model aimed at unifying previous analyses of checkpoint function by focusing on the Mad3-Cdc20 interaction PMID: 17369399

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    WD repeat CDC20/Fizzy family
  • 數(shù)據(jù)庫鏈接:

    KEGG: sce:YGL116W

    STRING: 4932.YGL116W



主站蜘蛛池模板: 日韩精品少妇无码受不了| 精品玖玖玖视频在线观看| 欧美日韩一卡2卡三卡4卡 乱码欧美孕交| 国产精品亚洲a∨天堂| 天天av天天翘天天综合网| 艳妇臀荡乳欲伦69调教视频| 精品毛片乱码1区2区3区 | 极品白嫩的小少妇| 久久精品中文字幕大胸| 久久九九有精品国产23百花影院 | 亚洲欧洲日产国码韩国| 亚洲精品国产高清在线观看| 欧美丰满老妇性猛交| 久久人搡人人玩人妻精品首页| 日产日韩亚洲欧美综合下载| 欧美性色老妇人| 国产奶头好大揉着好爽视频 | 精品国际久久久久999波多野| 国产精品久久久久久久久久久久人四虎 | 宅男色影视亚洲人在线| 国产成人精品视频ⅴa片软件竹菊| 久久人人爽人人爽人人爽| 国产成人欧美日本在线观看| 亚洲伊人久久精品影院| 中国女人内谢69xxxx视频| 欲色影视天天一区二区三区色香欲| 国产精品一区在线蜜臀| 内射人妻少妇无码一本一道| 亚洲一区二区三区香蕉| 亚洲人成小说网站色在线| 男女无遮挡猛进猛出免费观看视频 | 久久久久女教师免费一区| 国模无码人体一区二区| 香草乱码一二三四区别| 少妇激情一区二区三区视频小说| 亚洲深深色噜噜狠狠爱网站 | 亚洲欧美中文日韩在线视频一| 少妇人妻挤奶水中文视频毛片 | 秋霞成人午夜鲁丝一区二区三区| 熟睡中被义子侵犯在线播放| 欧美黑人巨大xxxxx视频|