在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Rat Z-DNA-binding protein 1 (Zbp1)

  • 中文名稱:
    大鼠Zbp1重組蛋白
  • 貨號(hào):
    CSB-YP837712RA
  • 規(guī)格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    大鼠Zbp1重組蛋白
  • 貨號(hào):
    CSB-EP837712RA
  • 規(guī)格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    大鼠Zbp1重組蛋白
  • 貨號(hào):
    CSB-EP837712RA-B
  • 規(guī)格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    大鼠Zbp1重組蛋白
  • 貨號(hào):
    CSB-BP837712RA
  • 規(guī)格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    大鼠Zbp1重組蛋白
  • 貨號(hào):
    CSB-MP837712RA
  • 規(guī)格:
  • 來源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    Zbp1; Dlm1; Z-DNA-binding protein 1; Tumor stroma and activated macrophage protein DLM-1
  • 種屬:
    Rattus norvegicus (Rat)
  • 蛋白長(zhǎng)度:
    full length protein
  • 表達(dá)區(qū)域:
    1-409
  • 氨基酸序列
    MAEASVDLGT GDNLEQKILQ VLSDAGSPVQ IDQLLKKLQV PKKILNQVLY RLKKEGRVSS PAPATWSLGG DGASGDGAPE IPEDSAAQPS LEERILRFLE TKGPQRALHI AKALGMTTAK EVNPILYSMR NKHLLTVSDT QMWTIYRSSQ EGQERACSGV GQESPAVIYQ QNPINMICQQ GPNSLISISN SKAIQIGHGN VMSRQTICGD PGPGTPHHAP LPVLEDAAAQ DTPPGTHGAQ LIHLNKSMLR RVQLGHGNEM NLERDPVEHP IFSFSSSPPE STTTADPETA FNMQTPEPGP HPEGGTTQIV HIKSCLLEDT TVGNNNKMTI HRRSKGGTKE SADSQELKED TGASSEATPP RSCLHTPSDS TLLTSELTAM ALGDGSPQIT ESMLREDEVQ AAETCQTQD
  • 蛋白標(biāo)簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Key innate sensor that recognizes and binds Z-RNA structures, which are produced by a number of viruses, such as herpesvirus, orthomyxovirus or flavivirus, and triggers different forms of cell death. Once activated upon Z-RNA-binding, ZBP1 interacts with RIPK3, inducing the complementary pathways of apoptosis, necroptosis and pyroptosis. Acts as a key activator of necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members: ZBP1-dependent necroptosis involves RIPK3 stimulation, which phosphorylates and activates MLKL, triggering execution of programmed necrosis. In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: ZBP1 recognizes and binds Z-RNA structures that are produced in infected nuclei by orthomyxoviruses, such as the influenza A virus (IAV), leading to ZBP1 activation, RIPK3 stimulation and subsequent MLKL phosphorylation, triggering disruption of the nuclear envelope and leakage of cellular DNA into the cytosol. ZBP1-dependent cell death in response to IAV infection promotes interleukin-1 alpha (IL1A) induction in an NLRP3-inflammasome-independent manner: IL1A expression is required for the optimal interleukin-1 beta (IL1B) production, and together, these cytokines promote infiltration of inflammatory neutrophils to the lung, leading to the formation of neutrophil extracellular traps. In some cell types, also able to restrict viral replication by promoting cell death-independent responses. In response to flavivirus infection in neurons, promotes a cell death-independent pathway that restricts viral replication: together with RIPK3, promotes a death-independent transcriptional program that modifies the cellular metabolism via up-regulation expression of the enzyme ACOD1/IRG1 and production of the metabolite itaconate. Itaconate inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes.
  • 亞細(xì)胞定位:
    Cytoplasm. Nucleus.
  • 數(shù)據(jù)庫鏈接:


主站蜘蛛池模板: 乌克兰美女浓毛bbw| 2020每日更新国产精品视频| 又色又爽又高潮免费视频国产 | 色综合天天综合网中文 | 色777狠狠狠综合| 欧美自拍亚洲综合图区| 三级国产三级在线| 亚洲欧美另类久久久精品| 欧美性欧美巨大黑白大战| 成人亚洲一区无码久久| 亚洲卡一卡二新区| 国产成人无码一区二区在线播放| 亚洲亚洲人成综合网络| 超碰色偷偷男人的天堂| 亚洲成片在线观看12345| 亚洲午夜福利精品无码不卡| 色爽黄1000部免费软件下载| 国产精品一区二区在线观看| 久久亚洲中文字幕精品一区| 麻豆国产丝袜白领秘书在线观看| www成人国产高清内射| 国产精品久久久久久无毒不卡| 亚洲熟妇色xxxxx欧美老妇| 日韩精品无码免费一区二区三区| 日本高清色本在线www| 国产又粗又硬又大爽黄老大爷视频 | 丰满熟妇人妻av无码区| 国产精品久久毛片av大全日韩| 亚洲伊人久久综合成人| 亚洲自偷自偷偷色无码中文| 麻豆国产一区二区三区四区| 亚洲国产精品一区二区久久hs| 欧美99久久无码一区人妻a片| 国产 日韩 另类 视频一区| 日产精品久久久久久久| 久久久亚洲欧洲日产国产成人无码| 欧美国产日韩a在线观看| 国产午夜亚洲精品理论片不卡| 国产亚洲精品美女久久久| 无码日韩精品一区二区免费| 亚洲午夜久久久久妓女影院|