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  4. Recombinant Rat Syntaxin-binding protein 5 (Stxbp5), partial

Recombinant Rat Syntaxin-binding protein 5 (Stxbp5), partial

  • 中文名稱：
    大鼠Stxbp5重組蛋白
  • 貨號：
    CSB-YP896240RA
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    大鼠Stxbp5重組蛋白
  • 貨號：
    CSB-EP896240RA
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    大鼠Stxbp5重組蛋白
  • 貨號：
    CSB-EP896240RA-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大鼠Stxbp5重組蛋白
  • 貨號：
    CSB-BP896240RA
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大鼠Stxbp5重組蛋白
  • 貨號：
    CSB-MP896240RA
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Stxbp5
  • Uniprot No.：
  • 別名：
    Stxbp5; Llgl3; Syntaxin-binding protein 5; Lethal(2) giant larvae protein homolog 3; Tomosyn-1
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Inhibits translocation of GLUT4 from intracellular vesicles to the plasma membrane. Plays a regulatory role in calcium-dependent exocytosis and neurotransmitter release. Inhibits membrane fusion between transport vesicles and the plasma membrane. May modulate the assembly of trans-SNARE complexes between transport vesicles and the plasma membrane. Competes with STXBP1 for STX1 binding.
  • 基因功能參考文獻：
    1. We suggest that tomosyn uses its CTD to arrest SNARE-dependent fusion reactions, whereas its NTD is required for the recruitment of tomosyn to vesicle fusion sites through syntaxin interaction. PMID: 25063806
    2. Unstructured loops in the WD40 domain mediate tomosyn's binding to SNAP25 and are involved in tomosyn's organization on the plasma membrane. PMID: 24782308
    3. Overexpression of transduced rat tomosyn 1 significantly impaired mouse hippocampus-dependent spatial memory & strategy in the water maze. It impaired paired-pulse facilitation in CA3 mossy fiber synapses. PMID: 23519441
    4. tomosyn controls synaptic vesicle fusion positively by serving as a placeholder for VAMP2. PMID: 20633536
    5. tomosyn is a soluble SNARE that directly competes with synaptobrevin in the formation of SNARE complexes and thus may function in down-regulating exocytosis. PMID: 12782620
    6. Tomosyn inhibits the priming step and impairs the efficiency of vesicle pool refilling in a calcium-dependent manner. PMID: 14983051
    7. tomosyn demarcates the plasma membrane by binding to syntaxin-1 phosphorylated by ROCK, and thereby regulates extension and retraction of neurites PMID: 15240567
    8. formation of a tight SNARE complex is important for the function of tomosyn PMID: 15316007
    9. Can negatively regulate exocytosis independently of syntaxin. PMID: 16033762
    10. This study investigates the role of tomosyn in the calcium metabolism pathway. PMID: 16186257
    11. In the pancreatic beta-cell, tomosyn negatively regulates insulin exocytosis. PMID: 16505218
    12. Tomosyn-1 is involved in a post-docking event that prepares secretory granules for fusion and is necessary to sustain exocytosis of pancreatic beta-cells in response to insulin secretagogues. PMID: 16787939
    13. Tomosyn inhibits neurotransmitter release by catalyzing oligomerization of the SNARE complex through the N-terminal WD-40 repeat domain in addition to the inhibitory activity of the C-terminal (VAMP)-like domain. PMID: 18936251
    14. conformational change of tomosyn mediated by the intramolecular interactions of the tail domain controls its inhibitory activity on the SNARE complex formation, leading to a regulated inhibition of neurotransmitter release. PMID: 19258327

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  • 亞細胞定位：
    Cytoplasm. Cell membrane; Peripheral membrane protein. Cytoplasmic vesicle membrane; Peripheral membrane protein. Cell junction, synapse. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle. Note=Cytoplasmic, and associated with vesicular membranes and the plasma membrane. Detected at synapses and on synaptic vesicles.
  • 蛋白家族：
    WD repeat L(2)GL family
  • 組織特異性：
    Isoform 1 is detected in heart, brain, lung, liver, skeletal muscle, kidney and testis. Isoform 2 is detected in brain and in testis. Isoform 3 is detected in testis.
  • 數據庫鏈接：


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