在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Rat Steroid 17-alpha-hydroxylase/17,20 lyase (Cyp17a1)

Recombinant Rat Steroid 17-alpha-hydroxylase/17,20 lyase (Cyp17a1)

  • 中文名稱：
    Recombinant Rat Steroid 17-alpha-hydroxylase/17,20 lyase(Cyp17a1)
  • 貨號：
    CSB-YP006392RA
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Rat Steroid 17-alpha-hydroxylase/17,20 lyase(Cyp17a1)
  • 貨號：
    CSB-EP006392RA-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Rat Steroid 17-alpha-hydroxylase/17,20 lyase(Cyp17a1)
  • 貨號：
    CSB-BP006392RA
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Rat Steroid 17-alpha-hydroxylase/17,20 lyase(Cyp17a1)
  • 貨號：
    CSB-MP006392RA
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Cyp17a1; Cyp17Steroid 17-alpha-hydroxylase/17,20 lyase; EC 1.14.14.19; 17-alpha-hydroxyprogesterone aldolase; EC 1.14.14.32; CYPXVII; Cytochrome P450 17A1; Cytochrome P450-C17; Cytochrome P450c17; Steroid 17-alpha-monooxygenase
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Full length protein
  • 表達區域：
    1-507
  • 氨基酸序列
    MWELVGLLLL ILAYFFWVKS KTPGAKLPRS LPSLPLVGSL PFLPRRGHMH VNFFKLQEKY GPIYSLRLGT TTTVIIGHYQ LAREVLIKKG KEFSGRPQMV TQSLLSDQGK GVAFADAGSS WHLHRKLVFS TFSLFKDGQK LEKLICQEAK SLCDMMLAHD KESIDLSTPI FMSVTNIICA ICFNISYEKN DPKLTAIKTF TEGIVDATGD RNLVDIFPWL TIFPNKGLEV IKGYAKVRNE VLTGIFEKCR EKFDSQSISS LTDILIQAKM NSDNNNSCEG RDPDVFSDRH ILATVGDIFG AGIETTTTVL KWILAFLVHN PEVKKKIQKE IDQYVGFSRT PTFNDRSHLL MLEATIREVL RIRPVAPMLI PHKANVDSSI GEFTVPKDTH VVVNLWALHH DENEWDQPDQ FMPERFLDPT GSHLITPTQS YLPFGAGPRS CIGEALARQE LFVFTALLLQ RFDLDVSDDK QLPRLEGDPK VVFLIDPFKV KITVRQAWMD AQAEVST
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    A cytochrome P450 monooxygenase involved in corticoid and androgen biosynthesis. Catalyzes 17-alpha hydroxylation of C21 steroids, which is common for both pathways. A second oxidative step, required only for androgen synthesis, involves an acyl-carbon cleavage. The 17-alpha hydroxy intermediates, as part of adrenal glucocorticoids biosynthesis pathway, are precursors of cortisol. Hydroxylates steroid hormones, pregnenolone and progesterone to form 17-alpha hydroxy metabolites, followed by the cleavage of the C17-C20 bond to form C19 steroids, dehydroepiandrosterone (DHEA) and androstenedione. Has 16-alpha hydroxylase activity. Catalyzes 16-alpha hydroxylation of 17-alpha hydroxy pregnenolone, followed by the cleavage of the C17-C20 bond to form 16-alpha-hydroxy DHEA. Also 16-alpha hydroxylates androgens, relevant for estriol synthesis. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH-ferrihemoprotein reductase).
  • 基因功能參考文獻：
    1. Data suggest that CYP17A1 and aromatase/Cyp19a1 are induced in hippocampus by the environmental pollutant/retinoid X receptor agonist tributyltin; thus, tributyltin appears to stimulate estradiol biosynthesis. PMID: 24679120
    2. Data from a rat model of polycystic ovary syndrome suggest that hyperandrogenism develops and this may partially up-regulate expression of steroidogenic enzymes (CYP17 and P450scc [cholesterol side-chain cleavage enzyme]) in ovarian tissue. PMID: 22798247
    3. these data demonstrate the occurrence of P450C(17) in the deep cerebellar nuclei of the rat PMID: 22800812
    4. Data demonstrate, for the first time, the presence and anatomical distribution of P450C(17) in the vestibular nuclei. PMID: 21388459
    5. Dibromoacetic acid can directly target rat Leydig cells and downregulate testicular CYP17 expression with a resulting decreased testicular testosterone production. PMID: 21046364
    6. immunolocalization of 3beta-hydroxysteroid dehydrogense, cytochrome P450c17 and androgen receptor were investigated in rat cumuli oophori of late pre-ovulatory follicles and in post-ovulatory COCs bearing fertilized oocytes PMID: 19775733
    7. Results suggest that PCB126 may affect testicular steroidogenesis by downregulating P450(17alpha), P450(scc) and have inhibitory effect on the testicular functions. PMID: 20356859
    8. 17beta-estradiol is synthesized by P45017alpha and P450 aromatase localized in hippocampal neurons from endogenous cholesterol PMID: 14694190
    9. CYP17 is expressed in rat kidney throughout the life-span and has a role in autonomous hormonal steroidogenesis PMID: 15261307
    10. Cyp17a1 in beta-cells of rat pancreas and its local steroidogenesis are reported. PMID: 18556192
    11. GDF-9 plays an important role in promoting preantral follicle growth by up-regulating follicular androgen biosynthesis. GDF-9 is essential for CYP17A1 expression during follicular development from the preantral to the early antral stage. PMID: 19213837
    12. The expression of the mouse CYP17A1 gene is epigenetically controlled. PMID: 19403566

    顯示更多

    收起更多

  • 亞細胞定位：
    Endoplasmic reticulum membrane. Microsome membrane.
  • 蛋白家族：
    Cytochrome P450 family
  • 數據庫鏈接：


主站蜘蛛池模板： 88国产精品欧美一区二区三区| а√天堂8资源在线官网| 中文字幕亚洲欧美日韩在线不卡 | 人妻在线日韩免费视频| 极品少妇hdxx麻豆hdxx| 成 人 亚洲 综合天堂| 97无码免费人妻超级碰碰碰碰| 奇米777四色影视在线看| 疯狂做受xxxx高潮视频免费| 日本三级手机在线播放线观看| 内射小寡妇无码| 国产小受呻吟gv视频在线观看| a片免费视频在线观看| 中国熟妇牲交视频免费| 97久久超碰精品视觉盛宴| 国产成人无码精品亚洲| 99久久国产露脸国语对白 | 久久天天躁狠狠躁夜夜av浪潮| 国产老太睡小伙子视频| 忘忧草在线社区www中国中文| 无码一区二区三区av免费| 亚洲人成人无码www| 亚洲中文在线精品国产| 国产真实乱人偷精品人妻| 免费无码av片在线观看| 久久久一本精品99久久精品66直播| 军人粗大的内捧猛烈进出视频| 欧洲成人一区二区三区| 久久精品免费国产大片| 成年片色大黄全免费网站久久高潮 | 波多野结衣美乳人妻hd电影欧美| av无码久久久久不卡蜜桃| 天堂亚洲国产中文在线| 亚洲精品少妇30p| 四川老熟女下面又黑又肥| 动漫精品专区一区二区三区| 精品人妻av区波多野结衣| 日韩精品区一区二区三vr| 亚洲人成网站在线无码| 福利姬国产精品一区在线| 97久久综合区小说区图片区|