在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Rat Sphingosine 1-phosphate receptor 2 (S1pr2), partial

  • 中文名稱:
    大鼠S1pr2重組蛋白
  • 貨號:
    CSB-YP020651RA1
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    大鼠S1pr2重組蛋白
  • 貨號:
    CSB-EP020651RA1
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    大鼠S1pr2重組蛋白
  • 貨號:
    CSB-EP020651RA1-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    大鼠S1pr2重組蛋白
  • 貨號:
    CSB-BP020651RA1
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    大鼠S1pr2重組蛋白
  • 貨號:
    CSB-MP020651RA1
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    S1pr2; Edg5; Sphingosine 1-phosphate receptor 2; S1P receptor 2; S1P2; AGR16; Endothelial differentiation G-protein coupled receptor 5; G-protein coupled receptor H218; Sphingosine 1-phosphate receptor Edg-5; S1P receptor Edg-5
  • 種屬:
    Rattus norvegicus (Rat)
  • 蛋白長度:
    Partial
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effects on most types of cells and tissues. Receptor for the chemokine-like protein FAM19A5. Mediates the inhibitory effect of FAM19A5 on vascular smooth muscle cell proliferation and migration.
  • 基因功能參考文獻:
    1. Sphingosine-1 phosphate (S1P)-mediated activation of S1PR2 plays an important role in regulating intestinal epithelial cell proliferation and migration. S1P significantly upregulated the expression of c-Myc, cyclin D1, E-cadherin and zona occluden-1 (ZO-1), which was completely inhibited by downregulation of S1PR2 expression with a shRNA. PMID: 27814635
    2. TGR5 activation reduced ICAM-1, TGF-beta1 and FN expressions induced by high glucose in glomerular mesangial cells, the mechanism might be through suppressing S1P/S1P2 signaling, thus ameliorating diabetic nephropathy. PMID: 27317945
    3. S1P contracted control colon via S1PR1 and S1PR2 and inflamed colon exclusively via S1PR2. Calcium influx (control) or release (inflamed) and calcium sensitization are involved in S1P-induced contraction. Exacerbated response to S1P in colitic colon segments may explain altered colonic motility reported in patients and experimental models of inflammatory bowel disease. PMID: 28493876
    4. Inhibition of S1PR2 down-regulate the expressions of SphK1 and MCP-1 in glomerular mesangial cells under high glucose. PMID: 25575056
    5. Conjugated bile acids promote cholangiocarcinoma growth through S1PR2. PMID: 24700501
    6. extracellular S1P induces COX-2 expression via activation of S1P2 and subsequent Gi and p42/p44 MAPK-dependent signaling in renal mesangial cells leading to enhanced PGE2 formation and cell migration that essentially requires COX-2. PMID: 24064301
    7. S1P may play an important role in the pathophysiology of portal hypertension with Rho kinase activation by way of S1P(2) . PMID: 22505286
    8. Results indicate that the impaired functions (such as chemotactic, wound healing, and morphogenetic responses) in senescent endothelial cells are mediated by the S1P(2) receptor. PMID: 22139303
    9. S1P2 receptor was significantly up-regulated under diabetic condition. S1P2 receptor mediated fibronectin expression through the activation of S1P-S1P2-MAPK axis in mesangial cells under high glucose condition. PMID: 22406263
    10. Conjugated bile acids activate the ERK1/2 and AKT signaling pathways primarily through S1P(2) in primary rodent hepatocytes. PMID: 21932398
    11. S1P modulates central intracellular signaling cascades and is antiproliferative in PC Cl(3) cells. S1P(2) receptor expression is modulated by insulin and TSH, two central growth factors in thyroid cell regulation. PMID: 15713536
    12. S1P (sphingosine-1-phosphate receptor)1 and S1P3 receptors promote, whereas S1P2 receptors antagonize, smooth muscle cell proliferation and phenotypic modulation in vitro in response to sphingosine-1-phosphate (S1P), or in vivo after vascular injury PMID: 18535287
    13. Data demonstrate the importance of S1P and the S1P(2) receptor as regulators of allergen-induced activation of mast cells in their natural environment in the rat lung. PMID: 19636535

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 1 family
  • 組織特異性:
    Expressed in all developing tissues with highest levels detected in primitive, transformed cells. Relative abundance: lung > kidney = skin = gut > spleen > brain > liver.
  • 數據庫鏈接:


主站蜘蛛池模板: 男人边做边吃奶头视频| 国产极品粉嫩泬免费观看| 中文字幕日韩欧美一区二区三区| www.-级毛片线天内射视视| 色综合久久久久综合99| 国产成人综合一区人人| 秋霞av鲁丝片一区二区| 亚洲精品久久久中文字幕痴女| 精品无码人妻一区二区三区品| 免费国产成人高清在线观看网站| 中文字幕va一区二区三区| 窝窝午夜看片| 色欲人妻aaaaaaa无码| 亚洲另类成人小说综合网| 688欧美人禽杂交狂配| 免费网站观看www在线观看| 色婷婷久久综合中文久久蜜桃av| 国产免费麻传媒精品国产av| 久久亚洲精品无码观看不卡| 国产色a在线观看| 久久99热人妻偷产国产| 亚洲人成网站在线观看69影院| 特黄做受又硬又粗又大视频小说| 极品少妇被后入内射视| 亚洲精品美女久久久久久久| 国产萌白酱喷水视频在线观看 | 日韩精品av一区二区三区| 草草久久97超级碰碰碰| 婷婷综合缴情亚洲| 久久久久久亚洲精品不卡| 国内精品久久久人妻中文字幕 | 国产sm调教折磨视频| 老司机无码精品a| 热の综合热の国产热の潮在线| 中文字幕人妻丝袜乱一区三区| 久久99热人妻偷产国产| av天堂永久资源网亚洲高清| 亚洲日韩一中文字暮av| 日日摸天天爽天天爽视频| 国产欧美日韩专区发布 | 久久精品国产只有精品96|