在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Rat Sphingosine 1-phosphate receptor 2 (S1pr2)-VLPs

  • 中文名稱:
    Recombinant Rat Sphingosine 1-phosphate receptor 2 (S1pr2)-VLPs
  • 貨號:
    CSB-MP020651RA
  • 規格:
    ¥5250
  • 圖片:
    • CSB-MP020651RA is detected by Mouse anti-6*His monoclonal antibody.
  • 其他:

產品詳情

  • 純度:
    The purity information is not available for VLPs proteins.
  • 生物活性:
    Not Test
  • 基因名:
  • Uniprot No.:
  • 別名:
    AGR16;Endothelial differentiation G-protein coupled receptor 5;G-protein coupled receptor H218;Sphingosine 1-phosphate receptor Edg-5 (S1P receptor Edg-5)
  • 種屬:
    Rattus norvegicus (Rat)
  • 蛋白長度:
    Full Length
  • 來源:
    Mammalian cell
  • 分子量:
    40.4 kDa
  • 表達區域:
    1-352aa
  • 氨基酸序列
    MGGLYSEYLNPEKVQEHYNYTKETLDMQETPSRKVASAFIIILCCAIVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGPVTLSLTPLQWFAREGSAFITLSASVFSLLAIAIERQVAIAKVKLYGSDKSCRMLMLIGASWLISLILGGLPILGWNCLDHLEACSTVLPLYAKHYVLCVVTIFSVILLAIVALYVRIYFVVRSSHADVAGPQTLALLKTVTIVLGVFIICWLPAFSILLLDSTCPVRACPVLYKAHYFFAFATLNSLLNPVIYTWRSRDLRREVLRPLLCWRQGKGATGRRGGNPGHRLLPLRSSSSLERGLHMPTSPTFLEGNTVV
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    C-terminal 10xHis-tagged(This tag can be tested only under denaturing conditions)
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein indeionized sterile water to a concentration of 0.1-1.0 mg/mL.Aliquot for long-term storage at -80℃. Solubilize for 60 minutes at room temperature with occasional gentle mixing. Avoid vigorous shaking or vortexing.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事項:
    The VLPs are expressed from human 293 cells (HEK293).Mix the sample gently by repeatedly pipetting it up and down. Do not vortex.Repeated freezing and thawing is not recommended.Store the protein at -20℃/-80℃ upon receiving it, and ensure to avoid repeated freezing and thawing, otherwise, it will affect the protein activity. The immunization strategy should be optimized (antigen dose, regimen and adjuvant).
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Receptor for the lysosphingolipid sphingosine 1-phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effects on most types of cells and tissues. Receptor for the chemokine-like protein FAM19A5. Mediates the inhibitory effect of FAM19A5 on vascular smooth muscle cell proliferation and migration.
  • 基因功能參考文獻:
    1. Sphingosine-1 phosphate (S1P)-mediated activation of S1PR2 plays an important role in regulating intestinal epithelial cell proliferation and migration. S1P significantly upregulated the expression of c-Myc, cyclin D1, E-cadherin and zona occluden-1 (ZO-1), which was completely inhibited by downregulation of S1PR2 expression with a shRNA. PMID: 27814635
    2. TGR5 activation reduced ICAM-1, TGF-beta1 and FN expressions induced by high glucose in glomerular mesangial cells, the mechanism might be through suppressing S1P/S1P2 signaling, thus ameliorating diabetic nephropathy. PMID: 27317945
    3. S1P contracted control colon via S1PR1 and S1PR2 and inflamed colon exclusively via S1PR2. Calcium influx (control) or release (inflamed) and calcium sensitization are involved in S1P-induced contraction. Exacerbated response to S1P in colitic colon segments may explain altered colonic motility reported in patients and experimental models of inflammatory bowel disease. PMID: 28493876
    4. Inhibition of S1PR2 down-regulate the expressions of SphK1 and MCP-1 in glomerular mesangial cells under high glucose. PMID: 25575056
    5. Conjugated bile acids promote cholangiocarcinoma growth through S1PR2. PMID: 24700501
    6. extracellular S1P induces COX-2 expression via activation of S1P2 and subsequent Gi and p42/p44 MAPK-dependent signaling in renal mesangial cells leading to enhanced PGE2 formation and cell migration that essentially requires COX-2. PMID: 24064301
    7. S1P may play an important role in the pathophysiology of portal hypertension with Rho kinase activation by way of S1P(2) . PMID: 22505286
    8. Results indicate that the impaired functions (such as chemotactic, wound healing, and morphogenetic responses) in senescent endothelial cells are mediated by the S1P(2) receptor. PMID: 22139303
    9. S1P2 receptor was significantly up-regulated under diabetic condition. S1P2 receptor mediated fibronectin expression through the activation of S1P-S1P2-MAPK axis in mesangial cells under high glucose condition. PMID: 22406263
    10. Conjugated bile acids activate the ERK1/2 and AKT signaling pathways primarily through S1P(2) in primary rodent hepatocytes. PMID: 21932398
    11. S1P modulates central intracellular signaling cascades and is antiproliferative in PC Cl(3) cells. S1P(2) receptor expression is modulated by insulin and TSH, two central growth factors in thyroid cell regulation. PMID: 15713536
    12. S1P (sphingosine-1-phosphate receptor)1 and S1P3 receptors promote, whereas S1P2 receptors antagonize, smooth muscle cell proliferation and phenotypic modulation in vitro in response to sphingosine-1-phosphate (S1P), or in vivo after vascular injury PMID: 18535287
    13. Data demonstrate the importance of S1P and the S1P(2) receptor as regulators of allergen-induced activation of mast cells in their natural environment in the rat lung. PMID: 19636535

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 1 family
  • 組織特異性:
    Expressed in all developing tissues with highest levels detected in primitive, transformed cells. Relative abundance: lung > kidney = skin = gut > spleen > brain > liver.
  • 數據庫鏈接:


主站蜘蛛池模板: 国产肉丝袜在线观看| 国产精品卡1卡2卡三卡四| 午夜伦yy44880影院| 亚洲国产成人精品无码区蜜柚| 人妻少妇熟女javhd| 亚洲精品无码一区二区| 丰满的人妻hd高清日本| 天堂va欧美va亚洲va好看va| 少妇人妻大乳在线视频不卡 | 精品综合久久久久久97| 日本无遮挡吸乳视频| 少妇人妻av毛片在线看| 国产成人无码a区在线| 无码精品人妻一区二区三区98 | 五月婷婷之综合缴情| 成人免费播放视频777777| 成年女人免费碰碰视频| 国产成人亚洲精品狼色在线| av无码一区二区二三区1区6区| 丰满少妇做爰视频爽爽和| 日本va欧美va欧美va精品| 色欲精品国产一区二区三区av| 国产高清不卡无码视频| 国产网曝门亚洲综合在线| 天天综合网天天综合色| 人人色在线视频播放| 国产白浆喷水在线视频| 亚洲欧美在线观看品| 亚洲情综合五月天| 日本簧片在线观看| 又大又粗又爽又黄的少妇毛片| 亚洲伊人色欲综合网无码中文 | 国产裸体歌舞一区二区| 在线欧美中文字幕农村电影| 97国产精东麻豆人妻电影 | 成年女人午夜性视频| 国产高清自产拍av在线| 少妇挑战三个黑人惨叫4p国语| 东京热毛片无码dvd一二三区| 亚洲乱码在线卡一卡二卡新区| 真实的国产乱xxxx在线|