在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Rat Securin (Pttg1)

Recombinant Rat Securin (Pttg1)

  • 中文名稱：
    大鼠Pttg1重組蛋白
  • 貨號：
    CSB-YP019074RA
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    大鼠Pttg1重組蛋白
  • 貨號：
    CSB-EP019074RA
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    大鼠Pttg1重組蛋白
  • 貨號：
    CSB-EP019074RA-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    大鼠Pttg1重組蛋白
  • 貨號：
    CSB-BP019074RA
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    大鼠Pttg1重組蛋白
  • 貨號：
    CSB-MP019074RA
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Pttg1; Pttg; Securin; Pituitary tumor-transforming gene 1 protein
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    2-199
  • 氨基酸序列
    ATLIFVDKD NEEPGSRLAS KDGLKLGSGV KALDGKLQVS TPRVGKVFGA PGLPKASRKA LGTVNRVTEK PVKSSKPLQS KQPTLSVKKI TEKSTKTQGS APAPDDAYPE IEKFFPFDPL DFESFDLPEE HQISLLPLNG VPLMILNEER GLEKLLHLDP PSPLQKPFLP WESDPLPSPP SALSALDVEL PPVCYDADI
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of p53/TP53. The negative regulation of p53/TP53 may explain the strong transforming capability of the protein when it is overexpressed. May also play a role in DNA repair via its interaction with Ku, possibly by connecting DNA damage-response pathways with sister chromatid separation.
  • 基因功能參考文獻：
    1. EAP1 (Pttg1) gene may be involved in the neuroendocrine control of female puberty in correlation with the kisspeptin signaling. PMID: 27250217
    2. Altered Cx43 expression modulates Pituitary tumor transforming gene expression, which correlates with prolactinoma development. PMID: 25023895
    3. calcium sensing receptor stimulates the synthesis of PTTG mRNA in a nonmetastasizing model for humoral hypercalcemia of malignancy and, in the process, might induce angiogenesis via VEGF. PMID: 12970167
    4. pttg1 could predict inter-individual susceptibility to D-galactosamine induced hepatotoxicity PMID: 19800905
  • 相關疾病：
    Has strong transforming capabilities on a variety of cell lines including NIH 3T3 fibroblasts and on athymic nude mice. Overexpressed in animals suffering from pituitary adenomas. The transforming capability may be due to its interaction and regulation of p53/TP53 pathway.
  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    Securin family
  • 組織特異性：
    Expressed at low level in most tissues, except in adult testis, where it is highly expressed. Expressed in both spermatocytes and spermatids.
  • 數據庫鏈接：


主站蜘蛛池模板： 无码av专区丝袜专区| 高清破外女出血av毛片| 精品国产一区二区三区久久狼 | 人妻系列无码一区二区三区| 国产又粗又猛又爽又黄的视频在线观看动漫| 少妇系列之白嫩人妻| 亚洲欧洲无码一区二区三区| 亚洲国产精品日本无码网站| 欧美视频网站www色| 四虎永久地址www成人| 成人午夜国产内射主播| 精品久久国产综合婷婷五月| 久久97久久97精品免视看| 精品国产aⅴ无码一区二区| 无码人妻丰满熟妇区毛片18| 国产麻豆精品福利在线| 色欲久久久中文字幕综合网| 日本丰满熟妇videos| 欧美zozo另类特级| 99久久精品国产一区二区| 男女无遮挡xx00动态图120秒| 免费体验区试看120秒 | 亚洲gv天堂无码男同在线观看| 2019国产品在线视频| 亚洲 成人 无码 在线观看| 日韩理论午夜无码| 五月婷婷久久草| 欧美极品少妇无套实战| 欧美第一黄网免费网站| 国产高清乱理伦片| 欧美精品一国产成人综合久久| 无码人妻精品一区二区| 久久精品成人免费国产| 人摸人人人澡人人超碰97| 国产农村老太xxxxhdxx| 亚洲在线国产日韩欧美| 久久婷婷狠狠综合激情| 拍真实国产伦偷精品| 欧美人与动牲交zooz乌克兰| 国产亚洲日韩在线aaaa| 久久久久亚洲精品|