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PTTG1

Securin is a protein in humans that is encoded by PTTG1 gene. Regulatory protein, which plays a central role in chromosome stability, in the p53/TP53 pathway, and DNA repair. Probably acts by blocking the action of key proteins. During the mitosis, it blocks Separase/ESPL1 function, preventing the proteolysis of the cohesin complex and the subsequent segregation of the chromosomes. At the onset of anaphase, it is ubiquitinated, conducting to its destruction and to the liberation of ESPL1. Its function is however not limited to a blocking activity, since it is required to activate ESPL1. Negatively regulates the transcriptional activity and related apoptosis activity of TP53. The negative regulation of TP53 may explain the strong transforming capability of the protein when it is overexpressed.

PTTG1 Antibodies

PTTG1 for Homo sapiens (Human)

PTTG1 Proteins

PTTG1 Proteins for Rattus norvegicus (Rat)

PTTG1 Proteins for Homo sapiens (Human)

PTTG1 Proteins for Gorilla gorilla gorilla (Lowland gorilla)

PTTG1 Proteins for Pan troglodytes (Chimpanzee)

PTTG1 Proteins for Bos taurus (Bovine)

PTTG1 Proteins for Sus scrofa (Pig)

PTTG1 Proteins for Mus musculus (Mouse)

PTTG1 ELISA Kit

PTTG1 ELISA Kit for Homo sapiens (Human)



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