在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Rat Omega-3 fatty acid receptor 1 (O3far1), partial

  • 中文名稱:
    大鼠Ffar4重組蛋白
  • 貨號:
    CSB-YP639132RA1
  • 規(guī)格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    大鼠Ffar4重組蛋白
  • 貨號:
    CSB-EP639132RA1
  • 規(guī)格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    大鼠Ffar4重組蛋白
  • 貨號:
    CSB-EP639132RA1-B
  • 規(guī)格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    大鼠Ffar4重組蛋白
  • 貨號:
    CSB-BP639132RA1
  • 規(guī)格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    大鼠Ffar4重組蛋白
  • 貨號:
    CSB-MP639132RA1
  • 規(guī)格:
  • 來源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    Ffar4; Gpr120; O3far1; Free fatty acid receptor 4; G-protein coupled receptor 120; Omega-3 fatty acid receptor 1
  • 種屬:
    Rattus norvegicus (Rat)
  • 蛋白長度:
    Partial
  • 蛋白標(biāo)簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能:
    G-protein-coupled receptor for long-chain fatty acids (LCFAs) with a major role in adipogenesis, energy metabolism and inflammation. Signals via G-protein and beta-arrestin pathways. LCFAs sensing initiates activation of phosphoinositidase C-linked G proteins GNAQ and GNA11 (G(q)/G(11)), inducing a variety of cellular responses via second messenger pathways such as intracellular calcium mobilization, modulation of cyclic adenosine monophosphate (cAMP) production, and mitogen-activated protein kinases (MAPKs). After LCFAs binding, associates with beta-arrestin ARRB2 that acts as an adapter protein coupling the receptor to specific downstream signaling pathways, as well as mediating receptor endocytosis. In response to dietary fats, plays an important role in the regulation of adipocyte proliferation and differentiation. Acts as a receptor for omega-3 polyunsaturated fatty acids (PUFAs) at primary cilium of perivascular preadipocytes, initiating an adipogenic program via cAMP and CTCF-dependent chromatin remodeling that ultimately results in transcriptional activation of adipogenic genes and cell cycle entry. Induces differentiation of brown and beige adipocytes probably via autocrine and endocrine functions of FGF21 hormone. Contributes to the thermogenic activation of brown adipose tissue and the browning of white adipose tissue. Activates brown adipocytes by initiating intracellular calcium signaling leading to mitochondrial depolarization and fission, and overall increased mitochondrial respiration. Consequently stimulates fatty acid uptake and oxidation in mitochondria together with UCP1-mediated thermogenic respiration, eventually reducing fat mass. Regulates bi-potential differentiation of bone marrow mesenchymal stem cells toward osteoblasts or adipocytes likely by up-regulating distinct integrins. In response to dietary fats regulates hormone secretion and appetite. Stimulates GIP and GLP1 secretion from enteroendocrine cells as well as GCG secretion in pancreatic alpha cells, thereby playing a role in the regulation of blood glucose levels. Negatively regulates glucose-induced SST secretion in pancreatic delta cells. Mediates LCFAs inhibition of GHRL secretion, an appetite-controlling hormone. In taste buds, contributes to sensing of dietary fatty acids by the gustatory system. During the inflammatory response, promotes anti-inflammatory M2 macrophage differentiation in adipose tissue. Mediates the anti-inflammatory effects of omega-3 PUFAs via inhibition of NLRP3 inflammasome activation. In this pathway, interacts with adapter protein ARRB2 and inhibits the priming step triggered by Toll-like receptors (TLRs) at the level of TAK1 and TAB1. Further inhibits the activation step when ARRB2 directly associates with NLRP3, leading to inhibition of proinflammatory cytokine release. Mediates LCFAs anti-apoptotic effects.
  • 基因功能參考文獻(xiàn):
    1. Data show that G protein-coupled receptor 120 protein (GPR120) appears strongly on interstitial cells and also on spermatogenic cells. PMID: 28192519
    2. GPR120 expression in beta-cells and GPR120-mediated insulinotropic effects are altered in obesity and diabetic states in distinct ways, and these alterations may be mediated by PPARgamma. PMID: 27980130
    3. demonstrated a GPR120-mediated novel anti-inflammatory pathway in specific intestinal epithelial cell types that could be of therapeutic relevance to intestinal inflammatory disorders PMID: 26791484
    4. results indicated that the beneficial metabolic role of DHA was attributed to its ability to regulate glucose via the GPR120-mediated AMPK pathway in the skeletal muscles PMID: 26134561
    5. These results suggest that GPR120 plays an important role in the cell motile activity induced by TPA in WB-F344 cells. PMID: 25380627
    6. These data shows a widespread expression of GPR120 in the gut epithelium and can not confirm a major role for GPR120 in the regulation of GLP-1 secretion. PMID: 24520357
    7. rat GPR120 is a G-protein-coupled receptor whose ligand is a free fatty acid, and it may play an important role in the FFA-associated physiological responses. PMID: 18320172

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cell membrane; Multi-pass membrane protein. Endosome membrane; Multi-pass membrane protein. Lysosome membrane; Multi-pass membrane protein. Cell projection, cilium membrane; Multi-pass membrane protein.
  • 蛋白家族:
    G-protein coupled receptor 1 family
  • 數(shù)據(jù)庫鏈接:


主站蜘蛛池模板: 免费无码精品黄av电影| 国产成人欧美日韩在线电影| 日韩欧美国产aⅴ另类| 免费观看的av毛片的网站| 老熟女五十路乱子交尾中出一区| 黑人巨茎大战欧美白妇| 丁香色婷婷国产精品视频| 99久久久国产精品免费蜜臀| 亚洲va久久久噜噜噜久久天堂| 成人电线在线播放无码| 国产成人高清亚洲一区妲妃| 在线精品国产一区二区三区| 老熟女重囗味hdxx70星空| 亚洲天堂男人影院| 亚洲日本一区二区一本一道| 国产在线观看无码的免费网站| 毛片完整版的免费观看| 鲁一鲁av2019在线| 日韩人妻无码一区二区三区俄罗斯| 337p日本欧洲亚洲大胆精筑| 就去干成人网| 6080yyy午夜理论片中无码| 在线 | 一区二区三区| 久久国产精品萌白酱免费| 亚洲精品无码久久毛片波多野吉衣| 午夜精品射精入后重之免费观看| 漂亮人妻被中出中文字幕| 亚洲成a人片77777kkkk| 8av国产精品爽爽ⅴa在线观看| 99久久免费国产精品| 熟妇的奶头又大又长奶水视频| 亲嘴扒胸摸屁股激烈网站 | 亚洲综合另类小说专区| 曰本无码人妻丰满熟妇啪啪| 中文字幕欧美日韩va免费视频| 久久精品国产999久久久| 巨乳美乳一区二区三区| 午夜熟女插插xx免费视频| 国产精品香港三级国产av| 久久人人超碰精品caoporen| 精品香蕉99久久久久网站|