在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Rat H (+)/Cl (-) exchange transporter 3, partial

Recombinant Rat H (+)/Cl (-) exchange transporter 3, partial

  • 中文名稱：
    Recombinant Rat H(+)/Cl(-) exchange transporter 3 ,partial
  • 貨號：
    CSB-YP345556RA
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Rat H(+)/Cl(-) exchange transporter 3 ,partial
  • 貨號：
    CSB-EP345556RA
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Rat H(+)/Cl(-) exchange transporter 3 ,partial
  • 貨號：
    CSB-EP345556RA-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Rat H(+)/Cl(-) exchange transporter 3 ,partial
  • 貨號：
    CSB-BP345556RA
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Rat H(+)/Cl(-) exchange transporter 3 ,partial
  • 貨號：
    CSB-MP345556RA
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Clcn3
  • Uniprot No.：
  • 別名：
    Clcn3H(+)/Cl(-) exchange transporter 3; Chloride channel protein 3; ClC-3; Chloride transporter ClC-3
  • 種屬：
    Rattus norvegicus (Rat)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons. The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons. The presence of conserved gating glutamate residues is typical for family members that function as antiporters.; Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons. May play an important role in neuronal cell function through regulation of membrane excitability by protein kinase C. It could help neuronal cells to establish short-term memory.
  • 基因功能參考文獻：
    1. Galactosemia caused the osmotic stress in lenses; it also markedly leads to the upregulations of aldose reductase, P-glycoprotein, and Clcn3 in lens epithelial cells, together resulting in obvious osmotic expansion in vitro and in vivo. PMID: 29527534
    2. Results have shown that the expression of ClC-3 was reduced in hypertrophic H9c2 cells, primary rat neonatal cardiomyocytes and myocardium of C57/BL/6 mice and that ClC-3 played an important role in beta-adrenergic cardiac hypertrophy. PMID: 29158167
    3. Data suggest that ClC3/Clcn3 expression is up-regulated by mechanical stimulation (persistent static compression here) in osteoblastic cell line and appears to participate in mechanically sensitive osteogenesis and gene expression regulation. PMID: 26436462
    4. Tyrosine 284 phosphorylation in the ClC-3 channel targeted by Src kinase is an important molecular mechanism for ClC-3 channel activation. PMID: 23536605
    5. Data suggest that Clcn3 activity and chloride ion movement due to hypotonic solution are more prominent in smooth muscle cell from femoral artery than from femoral vein; regulation of Clcn3 activity via tyrosine phosphorylation is prominent in veins. PMID: 23181279
    6. Our results demonstrated for the first time that rat bone marrow endothelial progenitor cells expressed volume-sensitive chloride currents and the corresponding gene and protein Clcn3. PMID: 22168445
    7. ClC-3 has protective effects on H2O2-induced apoptosis of basilar artery smooth muscle cells through influencing the mitochondrial signaling pathway. PMID: 21373935
    8. ClC-3 mRNA and protein expression levels were significantly higher in aortic smooth muscle and brain tissues of diabetic rats, but significantly decreased in kidney medulla tissue, relative to non-DM controls PMID: 20519092
    9. Downregulation of ClC-3 channel with ClC-3 antisense transfection reduced static pressure-evoked cell proliferation and cell cycle transition. PMID: 19910686
    10. ClC-3 is strongly expressed in the apical membrane of the caput epididymidis and the vas deferens and is less abundant in cells of the body and cauda epididymidis. PMID: 12475763
    11. Upregulation of ClC-3 is an adaptive response of inflamed pulmonary artery, which enhances the viability of pulmonary artery smooth muscle cells against reactive oxygen species. PMID: 15723096
    12. By increasing postsynaptic potentials in a Cl(-) dependent fashion, CLC-3 channels regulate neuronal excitability postsynaptically in immature neurons. PMID: 17046694
    13. PAF induces intracellular acidosis via activation of the Ca(2+)-dependent Cl(-) channel ClC-3, resulting in apoptosis of intestinal epithelial cells. PMID: 18339705
    14. The present study was to investigate the role of ClC-3 in cell cycle progression/distribution and the underlying mechanisms of proliferation. PMID: 18823498

    顯示更多

    收起更多

  • 亞細胞定位：
    [Isoform 1]: Lysosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein. Early endosome membrane; Multi-pass membrane protein.; [Isoform 2]: Early endosome membrane; Multi-pass membrane protein. Late endosome membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Chloride channel (TC 2.A.49) family, ClC-3/CLCN3 subfamily
  • 組織特異性：
    Abundant in brain, especially in the olfactory bulb, hippocampus, and cerebellum. A moderate expression is seen in the lung, kidney and adrenal gland.
  • 數據庫鏈接：


主站蜘蛛池模板： √最新版天堂资源网在线下载 | 成 人 黄 色 大片| 欧美第一黄网免费网站| 国产一区二区三区四区五区vm| 中文 在线 日韩 亚洲 欧美| 国产无遮挡又爽又黄的视频| 国产性色播播毛片| 亚洲国产一区二区三区在线观看| 精品久久久无码中文字幕边打电话| 中文国产乱码在线人妻一区二区| 人妻无码久久中文字幕专区| 欧美亚洲日韩不卡在线在线观看| 又色又爽又黄的视频软件app| 夜夜爽夜夜叫夜夜高潮漏水 | 久久久久久久综合狠狠综合| 人人妻人人狠人人爽 | 野外做受又硬又粗又大视频√| 国产熟女一区二区三区四区五区| 人妻少妇久久中文字幕456| 国产av福利久久| 成人性做爰aaa片免费看曹查理| 亚洲一区二区三区高清av| 大香线蕉伊人精品超碰| 国产亚洲精品自在久久vr| 亚洲愉拍自拍欧美精品| 日日鲁鲁鲁夜夜爽爽狠狠| 亚洲欧美成人综合图区| av制服丝袜白丝国产网站| 亚洲精品成人久久久| 超碰香蕉人人网99精品| 末发育娇小性色xxxxx| 久久人人97超碰caoporen| 丰满少妇69激情啪啪无| 男人添女人下部高潮视频| 一区二三区国产好的精华液o9| 人妻激情文学| 成年无码av片在线| 欧美级特黄aaaaaa片| 中文字幕精品av乱码在线| 久久天天躁狠狠躁夜夜网站| 亚洲精品久久久久久久观小说|