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  4. Recombinant Protein lin-12 (lin-12), partial

Recombinant Protein lin-12 (lin-12), partial

  • 中文名稱：
    秀麗隱桿線蟲lin-12重組蛋白
  • 貨號：
    CSB-YP321265CXY
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    秀麗隱桿線蟲lin-12重組蛋白
  • 貨號：
    CSB-EP321265CXY
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    秀麗隱桿線蟲lin-12重組蛋白
  • 貨號：
    CSB-EP321265CXY-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    秀麗隱桿線蟲lin-12重組蛋白
  • 貨號：
    CSB-BP321265CXY
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    秀麗隱桿線蟲lin-12重組蛋白
  • 貨號：
    CSB-MP321265CXY
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    lin-12
  • Uniprot No.：
  • 別名：
    lin-12; R107.8Protein lin-12; Abnormal cell lineage protein 12
  • 種屬：
    Caenorhabditis elegans
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Essential signaling protein which has a major role in many developmental processes; involved in cell fate decisions that require cell-cell interactions. Probable membrane-bound receptor for putative ligands lag-2, apx-1, dsl-1 and osm-11. Upon ligand activation, and releasing from the cell membrane, the lin-12/Notch intracellular domain (NICD) forms a transcriptional activator complex with lag-1 and lag-3 and regulates expression of various genes. Required for ventral cell fates in the postembryonic mesodermal lineage (M lineage) and in uterine precursor cells. Activity in cell fate decisions and tumorigenesis is negatively regulated by sel-10. Best known for involvement in cell-fate decisions during development, but also plays roles in other events. Regulates recovery from the dauer larval state. Modulates chemosensory avoidance of octanol and quiescence during molting. Promotes basement membrane mobility during tissue remodeling. Involved in establishing left-right asymmetry during intestinal organogenesis.
  • 基因功能參考文獻：
    1. These findings provide additional evidence highlighting the roles of LIN-12/Notch signaling in coordinating the formation of various components of the functional C. elegans egg-laying system. PMID: 24512688
    2. LIN-12 signaling is necessary for the suppression of lag-1 expression in the anchor cell in Caenorhabditis elegans. PMID: 23483278
    3. Here we identify two cis-regulatory regions from lin-12, both of them are specified by the presence of a conserved EXD/HOX composite binding site. the two Notch paralogs in the C. elegans nervous system. PMID: 23305862
    4. The termination of NOTCH signaling is tightly linked to cell-cycle progression. PMID: 23047528
    5. LIN-14 inhibition of LIN-12 contributes to precision and timing of C. elegans vulval fate patterning. PMID: 20951046
    6. Endocytosis-mediated downregulation of LIN-12/Notch upon Ras activation in Caenorhabditis elegans PMID: 12478297
    7. findings show that in addition to the MAPK phosphatase lip-1, LIN-12 activates expression of many different negative regulators of the EGFR-MAPK pathway in vulva precursor cells, which seem likely to inhibit activity of this pathway at different steps PMID: 14752159
    8. Lateral signal-inhibiting activity of LIN-12 resides in the extracellular domain and occurs at the apical surface of the vulval precursor cells. PMID: 16236769
    9. results suggest that lin-12, mir-61, and vav-1 form a feedback loop that helps maximize lin-12 activity in spatial patterning 2 of vulval precursor cells PMID: 16239437
    10. egl-43 acts downstream of or parallel to lin-12 in the anchor cell and ventral uterine precursor cell cell-fate specification at an early developmental stage PMID: 17215301
    11. Loss of sel-2 activity leads to basolateral mislocalization and increased accumulation of LIN-12 in vulval precursor cells (VPCs) in which LET-23 is not active, and to impaired downregulation of basolateral LET-23 in VPCs in which LIN-12 is active. PMID: 17215302
    12. study determined that dual regulation by LIN-12 and FOS-1 is required for egl-13 expression at specification and for complete rescue of egl-13 mutants PMID: 17942488
    13. Results suggest that the LIN-12/Notch pathway and the Sma/Mab TGFbeta pathway function independently in regulating dorsoventral patterning of the M lineage, with LIN-12/Notch required for ventral M lineage fates. PMID: 18036582
    14. C. elegans OSM-11 and homologous proteins act as coactivators for Notch receptors, allowing precise regulation of Notch receptor signaling in developmental programs in both vertebrates and invertebrates. PMID: 18700817

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  • 亞細胞定位：
    Apical cell membrane; Single-pass type I membrane protein.; [lin-12/Notch intracellular domain]: Nucleus.
  • 數據庫鏈接：

    KEGG: cel:CELE_R107.8

    STRING: 6239.R107.8

    UniGene: Cel.10278



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