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  4. Recombinant Probable lysine-specific histone demethylase 1 (spr-5), partial

Recombinant Probable lysine-specific histone demethylase 1 (spr-5), partial

  • 中文名稱：
    秀麗隱桿線蟲spr-5重組蛋白
  • 貨號(hào)：
    CSB-YP894087CXY
  • 說明書：
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    秀麗隱桿線蟲spr-5重組蛋白
  • 貨號(hào)：
    CSB-EP894087CXY
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    秀麗隱桿線蟲spr-5重組蛋白
  • 貨號(hào)：
    CSB-EP894087CXY-B
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    秀麗隱桿線蟲spr-5重組蛋白
  • 貨號(hào)：
    CSB-BP894087CXY
  • 說明書：
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    秀麗隱桿線蟲spr-5重組蛋白
  • 貨號(hào)：
    CSB-MP894087CXY
  • 說明書：
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    spr-5
  • Uniprot No.：
  • 別名：
    spr-5; Y40B1B.6Probable lysine-specific histone demethylase 1; EC 1.-.-.-; P110b homolog; Suppressor of presenilin 5
  • 種屬：
    Caenorhabditis elegans
  • 蛋白長(zhǎng)度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng)：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Probable histone demethylase that specifically demethylates 'Lys-4' of histone H3, a specific tag for epigenetic transcriptional activation, thereby acting as a corepressor. Acts by oxidizing the substrate by FAD to generate the corresponding imine that is subsequently hydrolyzed. Demethylates both mono- and di-methylated 'Lys-4' of histone H3. Participates in the transcriptional repression of the presenilin protein hop-1. May act via the formation of a multiprotein complex that remodel or modify the chromatin. Together with met-2, set-17 and set-26, required for transgenerational fertility.
  • 基因功能參考文獻(xiàn)：
    1. SPR-5 interacts with FNCM-1. SPR-5 absence suppresses the embryonic lethality and larval arrest observed in fncm-1 mutants. PMID: 29588287
    2. germ cells deficient for spr-5 and let-418 mainly reprogram as neurons, suggesting that neuronal fate might be the first to be derepressed in early embryogenesis. PMID: 24749077
    3. SPR-5 and MET-2 function cooperatively to reestablish an epigenetic ground state during passage through the germ line. PMID: 24979765
    4. Studies indicate that cellular identity in is the sum of interplay between PcG and Trx-G group proteins, as well as histone modifying enzymes MES-4 and SPR-5. PMID: 21538806
    5. Data suggest that SPR-5 may function directly in DSBR. PMID: 21768382

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  • 亞細(xì)胞定位：
    Nucleus.
  • 蛋白家族：
    Flavin monoamine oxidase family
  • 數(shù)據(jù)庫鏈接：


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