在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Pongo pygmaeus Leptin (LEP)

  • 中文名稱:
    Recombinant Pongo pygmaeus Leptin(LEP)
  • 貨號(hào):
    CSB-YP012870EXP
  • 規(guī)格:
  • 來(lái)源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Pongo pygmaeus Leptin(LEP)
  • 貨號(hào):
    CSB-EP012870EXP
  • 規(guī)格:
  • 來(lái)源:
    E.coli
  • 其他:
  • 中文名稱:
    Recombinant Pongo pygmaeus Leptin(LEP)
  • 貨號(hào):
    CSB-EP012870EXP-B
  • 規(guī)格:
  • 來(lái)源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Pongo pygmaeus Leptin(LEP)
  • 貨號(hào):
    CSB-BP012870EXP
  • 規(guī)格:
  • 來(lái)源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Pongo pygmaeus Leptin(LEP)
  • 貨號(hào):
    CSB-MP012870EXP
  • 規(guī)格:
  • 來(lái)源:
    Mammalian cell
  • 其他:

產(chǎn)品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    LEP; OBLeptin; Obesity factor
  • 種屬:
    Pongo pygmaeus (Bornean orangutan)
  • 蛋白長(zhǎng)度:
    full length protein
  • 表達(dá)區(qū)域:
    1-146
  • 氨基酸序列
    VPIQKVQDDT KTLIKTVITR INDISHTQSV SSKQKVTGLD FIPGLHPILT LSKMDQTLAV YQQILTSMPS RNVIQISNDL ENLRDLLHVL AFSKSCHLPW ASGLETLDRL GGVLEASGYS TEVVALSRLQ RSLQDMLWQL DLSPGC
  • 蛋白標(biāo)簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲(chǔ)存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項(xiàng):
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity. In the arcuate nucleus of the hypothalamus, activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides. In addition to its known satiety inducing effect, has a modulatory role in nutrient absorption. In the intestine, reduces glucose absorption by enterocytes by activating PKC and leading to a sequential activation of p38, PI3K and ERK signaling pathways which exerts an inhibitory effect on glucose absorption. Acts as a growth factor on certain tissues, through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1, via JAK2-STAT3 pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1 pathways. May also play an apoptotic role via JAK2-STAT3 pathway and up-regulation of BIRC5 expression. Pro-angiogenic, has mitogenic activity on vascular endothelial cells and plays a role in matrix remodeling by regulating the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). In innate immunity, modulates the activity and function of neutrophils by increasing chemotaxis and the secretion of oxygen radicals. Increases phagocytosis by macrophages and enhances secretion of pro-inflammatory mediators. Increases cytotoxic ability of NK cells. Plays a pro-inflammatory role, in synergy with IL1B, by inducing NOS2 wich promotes the production of IL6, IL8 and Prostaglandin E2, through a signaling pathway that involves JAK2, PI3K, MAP2K1/MEK1 and MAPK14/p38. In adaptive immunity, promotes the switch of memory T-cells towards T helper-1 cell immune responses. Increases CD4(+)CD25(-) T-cell proliferation and reduces autophagy during TCR (T-cell receptor) stimulation, through MTOR signaling pathway activation and BCL2 up-regulation.
  • 亞細(xì)胞定位:
    Secreted.
  • 蛋白家族:
    Leptin family


主站蜘蛛池模板: 乱中年女人伦av| 国产午夜亚洲精品国产成人小说| 亚洲中久无码永久在线观看同| 无码人妻熟妇av又粗又大| 国产熟妇高潮呻吟喷水| 国产卡二卡三卡四卡免费网址 | 亚洲vs日韩vs欧美vs久久| 国产精品国产对白熟妇| 日本乱妇乱子视频| 伊人久久精品一区二区三区| 国产婷婷色一区二区三区在线| 一二三四视频在线观看日本| 亚洲免费视频免在线观看| 国产一区二区内射最近更新| 成人欧美日韩一区二区三区| 免费国产h视频在线观看| 国产成人一区二区无码不卡在线| 99re久久精品国产首页| 爽爽影院免费观看| 男女啪啪做爰高潮无遮挡| 一本久久伊人热热精品中文字幕| 老湿机香蕉久久久久久| 亚洲国产精品综合久久20| 大战熟女丰满人妻av| 亚洲中文字幕无码中文| 嫩草研究院久久久精品| 亚洲aⅴ无码成人网站国产app | 欧美va亚洲va在线观看| 国产黑色丝袜在线观看下| 99久e在线精品视频在线| 午夜不卡无码中文字幕影院| 激情内射日本一区二区三区| 国产99视频精品免费视看9| 欧洲精品无码一区二区三区在线播放 | 成人天堂婷婷青青视频在线观看 | 色又黄又爽18禁免费视频| 麻豆成人av不卡一二三区| 久久久久99精品成人片三人毛片 | 国产亚洲精品久久久久久青梅| 国产成人亚洲综合精品| 熟妇人妻激情偷爽文|