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  4. Recombinant Phoneutria nigriventer GAMMA-ctenitoxin-Pn1a

Recombinant Phoneutria nigriventer GAMMA-ctenitoxin-Pn1a

  • 中文名稱：
    Recombinant Phoneutria nigriventer GAMMA-ctenitoxin-Pn1a
  • 貨號：
    CSB-YP348586EUV
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Phoneutria nigriventer GAMMA-ctenitoxin-Pn1a
  • 貨號：
    CSB-EP348586EUV
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Phoneutria nigriventer GAMMA-ctenitoxin-Pn1a
  • 貨號：
    CSB-EP348586EUV-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Phoneutria nigriventer GAMMA-ctenitoxin-Pn1a
  • 貨號：
    CSB-BP348586EUV
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Phoneutria nigriventer GAMMA-ctenitoxin-Pn1a
  • 貨號：
    CSB-MP348586EUV
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    N/A
  • Uniprot No.：
  • 別名：
    ; GAMMA-ctenitoxin-Pn1a; GAMMA-CNTX-Pn1a; Insecticidal neurotoxin Tx4(5-5); PnTx4(5-5); PnTx4-5-5; Toxin Pn4A
  • 種屬：
    Phoneutria nigriventer (Brazilian armed spider) (Ctenus nigriventer)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    35-81
  • 氨基酸序列
    CADING ACKSDCDCCG DSVTCDCYWS DSCKCRESNF KIGMAIRKKF C
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    This insecticidal neurotoxin targets two types of channels/receptors. It reversibly inhibits the N-methyl-D-aspartate (NMDA)-subtype of ionotropic glutamate receptor (GRIN). It inhibits glutamate uptake from rat brain synaptosomes, and blocks GRIN in hippocampal slices. It also acts on sodium channels of both insects and mammals. On sodium channel insects, it strongly slows down channel inactivation (EC(50)=212.5 nM) and causes an increase (105%) in peak amplitude (at 1 uM) of B.germanica sodium channel (Nav), whereas it inhibits all mammalien sodium channels tested with the following order of potency: Nav1.3/SCN3A (IC(50)=1.5 uM) > Nav1.6/SCN8A > Nav1.5/SCN5A > Nav1.4/SCN4A >= Nav1.2/SCN2A. In vivo, it is highly toxic to house fly (Musca domestica), cockroach (Periplaneta americana), and cricket (Acheta domesticus). In different rat pain models (induced by PGE2, carrageenan or glutamate), it shows antinociceptive effect that may be related to an inhibitory activity on the glutamatergic system.
  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Spider toxin Tx2 family
  • 組織特異性：
    Expressed by the venom gland.


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