在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mus musculus Receptor-type tyrosine-protein phosphatase S (Ptprs), partial

In Stock
  • 中文名稱:
    小鼠Ptprs重組蛋白
  • 貨號:
    CSB-BP019064MO
  • 規格:
    ¥3168
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 基因名:
  • Uniprot No.:
  • 別名:
    PTPNU-3 Receptor-type tyrosine-protein phosphatase sigma
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Partial
  • 來源:
    Baculovirus
  • 分子量:
    35.8 kDa
  • 表達區域:
    1631-1907aa
  • 氨基酸序列
    EPGEHVTGMELEFKRLASSKAHTSRFITASLPCNKFKNRLVNILPYESSRVCLQPIRGVEGSDYINASFIDGYRQQKAYIATQGPLAETTEDFWRALWENNSTIVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGAPKSGEGFIDFIGQVHKTKEQFGQDGPISVHCSAGVGRTGVFITLSIVLERMRYEGVVDIFQTVKVLRTQRPAMVQTEDEYQFCFQAALEYLGSFDHYAT
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged and C-terminal Myc-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycans. Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth. Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb. Functions as tyrosine phosphatase. Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3. Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases. Down-regulates TLR9-mediated activation of NF-kappa-B, as well as production of TNF, interferon alpha and interferon beta.
  • 基因功能參考文獻:
    1. Receptor protein tyrosine phosphatase sigma (RPTPsigma) regulates neuronal extension and acts as a presynaptic nexus for multiple protein and proteoglycan interactions during synaptogenesis PMID: 25385546
    2. Data demonstrate that synoviocytes are regulated by an RPTPsigma-dependent proteoglycan switch in vivo, which can be targeted for rheumatoid arthritis therapy. PMID: 25995222
    3. represents an evolutionarily conserved pDC-specific inhibitory receptor, and is required to prevent spontaneous IFN production and immune-mediated intestinal inflammation PMID: 26231120
    4. PTPRS-deficient bone marrow cells display increased cobblestone area-forming cell capacity and augmented transendothelial migration capacity, which was abrogated by RAC inhibition. PMID: 25415437
    5. the major binding sites for RPTPsigma in adult mouse brain are on neurons and are not proteoglycan GAG chains, as RPTPsigma binding overlaps with the neuronal marker NeuN and was not altered by treatments which eliminate chondroitin or heparan sulfate. PMID: 24530640
    6. Protein tyrosine phosphatase sigma targets apical junction complex proteins in the intestine and regulates epithelial permeability. PMID: 24385580
    7. The results of this study demonistrated that RPTPsigma limits synapse number and regulates synapse structure and function in the mature central nervous system. PMID: 22519304
    8. Structural insights into the homology and differences between mouse protein tyrosine phosphatase-sigma and human protein tyrosine phosphatase-sigma. PMID: 22027896
    9. study reports that RPTPsigma acts bimodally in sensory neuron extension, mediating chondroitin sulfate proteoglycan inhibition and Heparan sulfate proteoglycan growth promotion PMID: 21454754
    10. RPTPsigma modulates the actin cytoskeleton by regulating Rac GTPase activity through p250GAP. PMID: 20550964
    11. Our data suggest that RPTPsigma may function to prevent axonal growth after injury in the adult mammalian spinal cord and could be a target for promoting long distance regeneration after spinal cord injury. PMID: 19780196
    12. Enhanced rate of nerve regeneration and directional errors after sciatic nerve injury in PTPsigma knockout mice PMID: 12097500
    13. Data demonstrate that the alpha-hemolysin elevates the activity of receptor-like protein tyrosine phosphatase sigma (rPTPsigma). PMID: 15522239
    14. results support a model in which RPTPsigma inhibits axon regeneration in the adult injured optic nerves. PMID: 15797710
    15. N-cadherin is a physiological substrate for PTPsigma and it participates with beta-catenin in PTPsigma-mediated inhibition of axon growth PMID: 17060446
    16. PTPsigma binds with high affinity to neural chondroitin sulfate proteoglycans(CPSGs); binding involves chondroitin sulfate chains & a specific site on 1st immunoglobulin-like domain of PTPsigma; results indicate PTPsigma can act as a receptor for CSPGs PMID: 19833921

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Perikaryon. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Cell junction, synapse, synaptosome. Cell junction, synapse, postsynaptic density. Cell projection, neuron projection. Cell projection, growth cone.
  • 蛋白家族:
    Protein-tyrosine phosphatase family, Receptor class 2A subfamily
  • 組織特異性:
    Detected in brain cortex, cerebellum and thoracic spinal cord (at protein level). Detected in motor cortex and white matter of the spinal cord, but not in spinal cord gray matter. Isoform 1 and isoform 6 are predominantly expressed in the brain (cerebrum
  • 數據庫鏈接:


主站蜘蛛池模板: 婷婷五月综合色中文字幕| 国产精品久久久久久免费软件| a毛片免费全部播放自慰| 久青草久青草视频在线观看| 色悠久久久久久久综合网| 亚洲乱码日产精品bd在线观看| 2022久久国产精品免费热麻豆| 精品国产av一区二区果冻传媒| 国产精品 欧美 亚洲 制服| 欧美乱大交xxxxx潮喷l头像| 凹凸国产熟女精品视频| 久久爱www人成狠狠爱综合网| 国产啪精品视频网站免费尤物| 小荡货好紧好爽奶头大视频| 亚洲产国偷v产偷v自拍色戒| 在线播放免费人成毛片试看| 男女做爰无遮挡性视频| 无码成a毛片免费| 成人性生交大片免费看| 亚洲香蕉网久久综合影视| 日本无码一区二区三区不卡免费| 天天爱天天做狠狠久久做| 极品少妇hdxx麻豆hdxx| 国产av大陆精品一区二区三区| 国产成人av在线免播放观看| 亚洲 小说 欧美 激情 另类| 日本肉体xxxx裸体137大胆| 偷窥国产亚洲免费视频| 日本又黄又爽gif动态图| 人妻少妇中文字幕久久| 中文字字幕在线中文无码| 日韩亚洲国产综合高清| 欧美综合天天夜夜久久| 精品少妇ay一区二区三区| 最新的国产成人精品2022| 亚洲男人的天堂在线aⅴ视频 | 免费国精产品自偷自偷免费看| 国产精品丝袜肉丝出水| 国产果冻豆传媒麻婆精东| 国产欧美一区二区精品久久久| 曰韩少妇内射免费播放|