在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Receptor-type tyrosine-protein phosphatase S (Ptprs), partial

Recombinant Mouse Receptor-type tyrosine-protein phosphatase S (Ptprs), partial

  • 中文名稱：
    小鼠Ptprs重組蛋白
  • 貨號：
    CSB-YP019064MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Ptprs重組蛋白
  • 貨號：
    CSB-EP019064MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Ptprs重組蛋白
  • 貨號：
    CSB-MP019064MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Ptprs; Receptor-type tyrosine-protein phosphatase S; R-PTP-S; EC 3.1.3.48; PTPNU-3; Receptor-type tyrosine-protein phosphatase sigma; R-PTP-sigma
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Cell surface receptor that binds to glycosaminoglycans, including chondroitin sulfate proteoglycans and heparan sulfate proteoglycans. Binding to chondroitin sulfate and heparan sulfate proteoglycans has opposite effects on PTPRS oligomerization and regulation of neurite outgrowth. Contributes to the inhibition of neurite and axonal outgrowth by chondroitin sulfate proteoglycans, also after nerve transection. Plays a role in stimulating neurite outgrowth in response to the heparan sulfate proteoglycan GPC2. Required for normal brain development, especially for normal development of the pituitary gland and the olfactory bulb. Functions as tyrosine phosphatase. Mediates dephosphorylation of NTRK1, NTRK2 and NTRK3. Plays a role in down-regulation of signaling cascades that lead to the activation of Akt and MAP kinases. Down-regulates TLR9-mediated activation of NF-kappa-B, as well as production of TNF, interferon alpha and interferon beta.
  • 基因功能參考文獻：
    1. Receptor protein tyrosine phosphatase sigma (RPTPsigma) regulates neuronal extension and acts as a presynaptic nexus for multiple protein and proteoglycan interactions during synaptogenesis PMID: 25385546
    2. Data demonstrate that synoviocytes are regulated by an RPTPsigma-dependent proteoglycan switch in vivo, which can be targeted for rheumatoid arthritis therapy. PMID: 25995222
    3. represents an evolutionarily conserved pDC-specific inhibitory receptor, and is required to prevent spontaneous IFN production and immune-mediated intestinal inflammation PMID: 26231120
    4. PTPRS-deficient bone marrow cells display increased cobblestone area-forming cell capacity and augmented transendothelial migration capacity, which was abrogated by RAC inhibition. PMID: 25415437
    5. the major binding sites for RPTPsigma in adult mouse brain are on neurons and are not proteoglycan GAG chains, as RPTPsigma binding overlaps with the neuronal marker NeuN and was not altered by treatments which eliminate chondroitin or heparan sulfate. PMID: 24530640
    6. Protein tyrosine phosphatase sigma targets apical junction complex proteins in the intestine and regulates epithelial permeability. PMID: 24385580
    7. The results of this study demonistrated that RPTPsigma limits synapse number and regulates synapse structure and function in the mature central nervous system. PMID: 22519304
    8. Structural insights into the homology and differences between mouse protein tyrosine phosphatase-sigma and human protein tyrosine phosphatase-sigma. PMID: 22027896
    9. study reports that RPTPsigma acts bimodally in sensory neuron extension, mediating chondroitin sulfate proteoglycan inhibition and Heparan sulfate proteoglycan growth promotion PMID: 21454754
    10. RPTPsigma modulates the actin cytoskeleton by regulating Rac GTPase activity through p250GAP. PMID: 20550964
    11. Our data suggest that RPTPsigma may function to prevent axonal growth after injury in the adult mammalian spinal cord and could be a target for promoting long distance regeneration after spinal cord injury. PMID: 19780196
    12. Enhanced rate of nerve regeneration and directional errors after sciatic nerve injury in PTPsigma knockout mice PMID: 12097500
    13. Data demonstrate that the alpha-hemolysin elevates the activity of receptor-like protein tyrosine phosphatase sigma (rPTPsigma). PMID: 15522239
    14. results support a model in which RPTPsigma inhibits axon regeneration in the adult injured optic nerves. PMID: 15797710
    15. N-cadherin is a physiological substrate for PTPsigma and it participates with beta-catenin in PTPsigma-mediated inhibition of axon growth PMID: 17060446
    16. PTPsigma binds with high affinity to neural chondroitin sulfate proteoglycans(CPSGs); binding involves chondroitin sulfate chains & a specific site on 1st immunoglobulin-like domain of PTPsigma; results indicate PTPsigma can act as a receptor for CSPGs PMID: 19833921

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Single-pass type I membrane protein. Cell projection, axon. Perikaryon. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Cell junction, synapse, synaptosome. Cell junction, synapse, postsynaptic density. Cell projection, neuron projection. Cell projection, growth cone.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Receptor class 2A subfamily
  • 組織特異性：
    Detected in brain cortex, cerebellum and thoracic spinal cord (at protein level). Detected in motor cortex and white matter of the spinal cord, but not in spinal cord gray matter. Isoform 1 and isoform 6 are predominantly expressed in the brain (cerebrum
  • 數據庫鏈接：


主站蜘蛛池模板： 欧美人与禽zozzo性伦交| 少妇性l交大片毛多| 国产成人午夜福利在线观看视频| 国产午夜成人无码免费| 无码中文字幕乱在线观看| 国产日韩在线时看高清视频 | 玩弄丰满熟妇xxxxx性60| 久久经精品久久精品免费观看| 国产亚洲曝欧美不卡精品| 亚洲欧美成人一区二区三区| 欧美丰满少妇xxxx性| 日本欧美一区二区三区在线播放| 中文字幕欧美亚州视频免费| 国产精品人成视频免费999| 久久9精品区-无套内射无码| 99热精品国自产拍天天拍| 国产亚洲精品在av| 成年女性特黄午夜视频免费看| 亚洲色无码专区在线观看精品| 黄网站免费永久在线观看下载| 成人做爰视频www| 麻豆国产人妻欲求不满谁演的| 天美传媒精品1区2区3区| 国产乱子伦一区二区三区四区五区 | 欧洲性久久精品| 国产精品禁忌a片特黄a片| 久久午夜福利电影| 久久久久人妻精品一区蜜桃| 国产模特嫩模私拍视频在线| 美国一区二区三区无码视频| 男女性色大片免费网站| av成人无码无在线观看| 秋霞国产精品一区二区| 国产精品丰臀| 国产婷婷成人久久av免费高清| 久久爱www人成狠狠爱综合网| 日日日日做夜夜夜夜无码| 麻豆精品久久久久久久99蜜桃| 少妇特殊按摩高潮惨叫无码| 久久婷婷人人澡人人爽人人喊| 日韩免费无码专区精品观看|