在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Pde10a)

Recombinant Mouse cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A (Pde10a)

  • 中文名稱：
    小鼠Pde10a重組蛋白
  • 貨號：
    CSB-YP807478MO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Pde10a重組蛋白
  • 貨號：
    CSB-EP807478MO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Pde10a重組蛋白
  • 貨號：
    CSB-EP807478MO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Pde10a重組蛋白
  • 貨號：
    CSB-BP807478MO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Pde10a重組蛋白
  • 貨號：
    CSB-MP807478MO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Pde10a; cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A; EC 3.1.4.17; EC 3.1.4.35
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-790
  • 氨基酸序列
    MSNDSTEGTV GSCNATGLTD EKVKAYLSLH PQVLDEFVSE SVSAETVEKW LKRKTNKAKD EPSPKEVSRY QDTNMQGVVY ELNSYIEQRL DTGGDNHLLL YELSSIIRIA TKADGFALYF LGECNNSLCV FIPPGMKEGQ PRLIPAGPIT QGTTISAYVA KSRKTLLVED ILGDERFPRG TGLESGTRIQ SVLCLPIVTA IGDLIGILEL YRHWGKEAFC LSHQEVATAN LAWASVAIHQ VQVCRGLAKQ TELNDFLLDV SKTYFDNIVA IDSLLEHIMI YAKNLVNADR CALFQVDHKN KELYSDLFDI GEEKEGKPIF KKTKEIRFSI EKGIAGQVAR TGEVLNIPDA YADPRFNREV DLYTGYTTRN ILCMPIVSRG SVIGVVQMVN KISGSAFSKT DENNFKMFAV FCALALHCAN MYHRIRHSEC IYRVTMEKLS YHSICTSEEW QGLMRFNLPA RICRDIELFH FDIGPFENMW PGIFVYMIHR SCGTSCFELE KLCRFIMSVK KNYRRVPYHN WKHAVTVAHC MYAILQNNNG LFTDLERKGL LIACLCHDLD HRGFSNSYLQ KFDHPLAALY STSTMEQHHF SQTVSILQLE GHNIFSTLSS SEYEQVLEII RKAIIATDLA LYFGNRKQLE EMYQTGSLNL HNQSHRDRVI GLMMTACDLC SVTKLWPVTK LTANDIYAEF WAEGDEMKKL GIQPIPMMDR DKRDEVPQGQ LGFYNAVAIP CYTTLTQILP PTEPLLKACR DNLNQWEKVI RGEETAMWIS GPGPAPSKST PEKLNVKVED
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate. May play a critical role in regulating cAMP and cGMP levels in the striatum, a region of the brain that contributes to the control of movement and cognition.
  • 基因功能參考文獻：
    1. Through a combination of pharmacological and genetic tools, study provides convergent evidence of D2 (rather than D1) pathway dominant effects of PDE10A inhibition in rodents PMID: 26256420
    2. A knock-in mouse model carrying the homologous p.Tyr97Cys variant had decreased striatal PDE10A and also displayed motor abnormalities PMID: 27058446
    3. Its alteration leads to a cause of Huntington disease. PMID: 25018107
    4. phosphorylation of PDE10 has an impact on the interaction with other signaling proteins in the corpus striatum PMID: 25762721
    5. data show that PDE10A plays a pivotal role in striatal signaling and striatum-mediated salience attribution PMID: 24698799
    6. findings reveal a dynamic interplay between PDE10A activity, level of neuronal network depolarization and degree of dopaminergic tone in the ability of D1 receptors to facilitate the GABAergic transmission to SNpr neurons. PMID: 23973317
    7. PDE10A deficiency produces a decrease in caloric intake without affecting meal frequency, daytime versus nighttime feeding behavior, or locomotor activity. PMID: 24101672
    8. PDE10A-deficient mice showed changes in appetitively as well as aversively motivated responding, and in visuospatial learning and memory, which could not be reduced to neuromotor impairments. PMID: 21130175
    9. Observed suppression of PDE10A activity significantly inhibits gene expression in the striatum and predicts neuroprotective effects in models of Huntington's disease. PMID: 20923867
    10. Striatal phosphodiesterase mRNA and protein levels are reduced in Huntington's disease transgenic mice prior to the onset of motor symptoms. PMID: 14751289
    11. findings suggest that PDE10A is involved in regulating striatal output, possibly by reducing the sensitivity of medium spiny neurons to glutamatergic excitation PMID: 16769090
    12. PDE10A knockout mice showed a significant change in striatal dopamine turnover, which was accompanied by an enhanced locomotor response to amphetamine PMID: 18061215

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm.
  • 蛋白家族：
    Cyclic nucleotide phosphodiesterase family
  • 組織特異性：
    Detected in striatum (at protein level). Detected in testis and brain.
  • 數據庫鏈接：


主站蜘蛛池模板： 成人无码免费一区二区三区| 成人国产一区二区精品小说| 麻豆md0077饥渴少妇| 宅宅少妇无码| 中文字幕在线亚洲精品| 亚洲国产精品18久久久久久| 天天做天天爱天天要天天| 永久免费观看美女裸体视频的网站| 亚洲狠狠婷婷综合久久久久图片| 国产精品特级露脸av毛片| 无码人妻丰满熟妇区免费| 亚洲一区二区制服在线| 国产又色又爽又黄的在线观看| 国产日产人妻精品精品| 国产精品乱码一区二区三区| 国产aⅴ爽av久久久久久| 伊人色综合网久久天天| 亚洲xxxx做受欧美| 国产精品视频免费播放| 午夜免费无码福利视频麻豆| 77se77亚洲欧美在线| 亚洲综合欧美在线一区在线播放| 国产又大又硬又粗| 欧美日韩精品一区二区视频| 久久爱www人成狠狠爱综合网| 亚洲乱码中文字幕综合234| 极品少妇的粉嫩小泬视频| 韩国精品一区二区三区四区 | 国产高清在线精品一区免费| 国产精欧美一区二区三区 | 国产又粗又硬又大爽黄老大爷视频 | 精品无码成人片一区二区98| 97久久综合区小说区图片区| 3p人妻少妇对白精彩视频| 欧美综合乱图图区乱图图区| 国产伦精品一区二区三区免.费 | 少妇和邻居做不戴套视频| 九九久久精品国产| 精品夜夜爽欧美毛片视频| 亚洲中文字幕av不卡无码| 少妇午夜av一区|