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  4. Recombinant Mouse Zinc finger E-box-binding homeobox 1 (Zeb1), partial

Recombinant Mouse Zinc finger E-box-binding homeobox 1 (Zeb1), partial

  • 中文名稱：
    小鼠Zeb1重組蛋白
  • 貨號：
    CSB-YP727061MO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Zeb1重組蛋白
  • 貨號：
    CSB-EP727061MO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Zeb1重組蛋白
  • 貨號：
    CSB-EP727061MO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Zeb1重組蛋白
  • 貨號：
    CSB-BP727061MO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Zeb1重組蛋白
  • 貨號：
    CSB-MP727061MO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Zeb1
  • Uniprot No.：
  • 別名：
    Zeb1; Tcf8; Zfhx1a; Zfx1a; Zfx1haZinc finger E-box-binding homeobox 1; Delta EF1; Transcription factor 8; TCF-8; Zinc finger homeobox protein 1a; MEB1
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Acts as a transcriptional repressor. Binds to E-box sequences in the immunoglobulin heavy chain enhancer as well as in the regulatory regions of many other tissue-specific genes. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3'). Promotes tumorigenicity by repressing stemness-inhibiting microRNAs.
  • 基因功能參考文獻：
    1. The results suggest that the interaction between Zeb1, Hdac2, and eNOS is required for early mesendodermal differentiation of naive mouse embryonic stem cells. PMID: 29599503
    2. miR-1199-5p acts in a reciprocal double-negative feedback loop with the epithelial-mesenchymal transition transcription factor Zeb1 PMID: 29079737
    3. Trichostatin A (TSA, a HDAC inhibitor) addition significantly attenuates MTX unsensitivity caused by dysfunction of LMO2/ZEB1 signaling. In conclusion, these findings have identified a molecular mechanism underlying LMO2/ZEB1-mediated leukaemogenesis, paving a way for treating T-ALL with a new strategy of epigenetic inhibitors. PMID: 29778661
    4. NAC1 downregulates the E-cadherin repressor ZEB1 directly via transcriptional repression. PMID: 28781078
    5. These data establish ZEB1 as a key factor in the tumor microenvironment and for maintaining tumor-associated macrophages' tumor-promoting functions. PMID: 29038174
    6. astrocyte precursor invasion into the Zeb1(-/-) mutant white matter is delayed, and induction of their differentiation is postponed. PMID: 27806288
    7. The authors report that zinc finger and homeobox transcription factor-1 (Zeb1), a master regulator of epithelial polarity, controls neuronal differentiation by transcriptionally repressing polarity genes in neuronal progenitors. PMID: 27178982
    8. activation of hepatic H19RNA promoted cholestatic liver fibrosis through the ZEB1/EpCAM signaling pathway PMID: 28407375
    9. Furthermore, activation of the EMT program on its own, as orchestrated by Zeb1, is sufficient to incite metastatic outgrowth by causing carcinoma cells to enter stably into a metastasis-initiating cell state. PMID: 27530323
    10. Epithelial mesenchymal transformation-transcription factor Zeb1 is a key driver of pancreatic tumour progression from early tumorigenesis to late-stage metastasis, underscoring the important role of EMT activation in these processes. PMID: 28414315
    11. Data suggest that, in a cell transdifferentiation system to convert mouse embryonic fibroblasts into functional neurons (transplanted into hippocampus), expression of Zeb1 is up-regulated during the early stages of transdifferentiation; knockdown of Zeb1 expression dramatically attenuates cell transdifferentiation efficiency; Zeb1 overexpression up-regulates expression of neuron-specific genes. PMID: 28500132
    12. This work has established a new role for ZEB1 as an inhibitor of senescence in cancer cells, thus expanding the set of cancer cell hallmarks regulated by ZEB1. PMID: 27965283
    13. The results suggest that an antagonistic cascade exists between the TGF-beta1/Smad/deltaEF1 pathways and Npr1 expression and receptor signaling that is relevant to renal and vascular remodeling, and may be critical in the regulation of blood pressure and cardiovascular homeostasis. PMID: 26934489
    14. Porphyromonas gingivalis regulates ZEB1 expression in gingival epithelial cells. PMID: 26639759
    15. decrease of ZEB1 expression resulted in inhibitory effects on the B16F10 CD133+CD44+ cancer-stem-cell-like properties, and reduced the tumorigenesis and metastatic potential in the melanoma model PMID: 26559025
    16. CRP suppresses expression of N-cadherin (p < 0.01), a mesenchymal marker of EMT, and ZEB-1, an EMT-related transcription factor (p < 0.01). These findings suggest that CRP inhibits EMT in a MCA-38 tumor-bearing mouse model. PMID: 25864110
    17. Zeb1 affects epithelial cell adhesion by diverting glycosphingolipid metabolism. PMID: 25643708
    18. Ras induction of ZEB1 is required for tumour initiation in a lung adenocarcinoma model via Pten repression. A lower threshold of ZEB1 is sufficient for cancer initiation, whereas further induction is necessary for tumour metastasis. PMID: 25434817
    19. ZEB1, an epithelial-to-mesenchymal transition activator and transcriptional repressor of miR-200, relieves miR-200 repression of PD-L1 on tumour cells. PMID: 25348003
    20. uncover roles for Zeb1/2 family members in the developing Dorsal root ganglias PMID: 25942625
    21. Data indicate that transcription factor ZEB1 knockdown perturbs the expression of adipogenic regulators. PMID: 25163748
    22. Loss of Zeb2 in the melanocyte lineage results in a downregulation of the Microphthalmia-associated transcription factor (Mitf) and melanocyte differentiation markers concomitant with an upregulation of Zeb1. PMID: 24769727
    23. ASPP2 prevents beta-catenin from transactivating ZEB1 directly by forming an ASPP2-beta-catenin-E-cadherin ternary complex PMID: 25344754
    24. In culture, deltaEF1 repressed betaB1-crystallin promoter activity, suggesting that it may also turn off lens gene expression following surgery, contributing to "fibrotic Posterior capsular opacification" development. PMID: 25082886
    25. Kras/Tp53-mutant lung adenocarcinoma develops metastatic disease due to high expression of ZEB1 PMID: 24762440
    26. Hypoxia within spheres together with loss of Zeb1 repression synergize to cause superinduction of Hif1a, which in turn leads to induction of the DNA demethylase Aid/Aicda, demethylation of the Oct4 promoter/enhancer and multipotency. PMID: 23554223
    27. Because miR-200 represses Bmi1, induction of ZEB1 leads to induction of Bmi1. Rb1 pathway status then dictates the opposing effects of mutant Ras on the ZEB1-miR-200 loop in primary versus cancer cells. PMID: 24371144
    28. ZEB1 Promotes invasiveness of colorectal carcinoma cells through the opposing regulation of uPA and PAI-1. PMID: 23340304
    29. The pattern of gene expression associated with muscle differentiation is accelerated in ZEB1(-/-) mouse embryos. PMID: 23339872
    30. these results reveal roles for miR-200b and miR-429, and their target the Zeb1 gene, in the regulation of mammalian reproduction. PMID: 23765281
    31. induction of ZEB1 is required for Ras-initiated tumor formation. ZEB1 is then further induced by Ras, beyond the level seen with Rb1 mutation PMID: 23443660
    32. A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity. PMID: 22761313
    33. Expression of both Zeb1 was detected in the mesenchyme of the mouse palate, while miR-200b was expressed in the medial edge epithelium. PMID: 22261924
    34. Zeb1 , which were mediated by BMP4, play an important role in neural-crest-derived craniofacial organ morphogenesis, such as tooth development. PMID: 22350174
    35. deltaEF1 family proteins repress the expression of ESRPs to regulate alternative splicing during TGF-beta-induced EMT and the progression of breast cancers PMID: 22037216
    36. a noncoding point mutation of Zeb1 acts via a gain-of-function to disrupt regulation of Zeb1(Tw) expression, epithelial-mesenchymal cell fate or interactions, and structural development of the inner ear PMID: 21980308
    37. The association of misregulation of the ZEB1/miR-200b pathway with auditory and vestibular defects in the Twirler mutant mice uncovers a novel mechanism underlying deafness and balance disorders PMID: 21980309
    38. role in olfactory nerve abnormalities PMID: 11776395
    39. direct binding of TMPRSS2/ERG to the promoter of ZEB1 but not ZEB2 PMID: 21747944
    40. These findings implicate the miR-200 family and their targets, ZEB1 and ZEB2, as unique regulators of uterine quiescence and contractility during pregnancy and labor. PMID: 21079000
    41. Decreasing ZEB1 and ZEB2 expression with shRNAs was sufficient to re-establish epithelial features. PMID: 20025777
    42. dual effect of deltaEF1 in promoting breast cancer cell proliferation, by differentially regulating the cell cycle regulatory proteins. PMID: 20006705
    43. The ZEB1 transcription factor regulates the accumulation of adipose tissue. PMID: 20041147
    44. Result found ZEB1 to be essential for neural stem cell survival in vitro. PMID: 19785035
    45. Delta-EF1 is an in vivo negative regulator of Ihh expression in the growth plate. PMID: 19948490
    46. Expressed in a cell population immediately adjacent to cartilage anlagen as well as in developing tendons in embryonic limbs. PMID: 12609600
    47. Embryonic gene expression of Zfhep/deltaEF1 protein in the palate and neurons of the central nervous system. PMID: 14643678
    48. Data show that pro-collagen type I alpha 2 expression is activated through binding of Nkx2.5 and is repressed by the binding of deltaEF1/ZEB1 PMID: 15226419
    49. deltaEF1 has a role in suppressing integrin alpha 7 expression in myoblasts by displacing MYOD and competing for p300/CBP co-activator PMID: 16129691
    50. delta EF1 synergizes with FOXO transcription factors in B lymphocytes to strongly activate transcription from promoters of Ccng2 (encoding cyclin G2) and Rbl2 (p130). PMID: 16493026

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    Delta-EF1/ZFH-1 C2H2-type zinc-finger family
  • 組織特異性：
    Expressed in the external germinal layer (EGL) and internal granular layer (IGL) of the cerebellum (at protein level).
  • 數據庫鏈接：

    KEGG: mmu:21417

    STRING: 10090.ENSMUSP00000025081

    UniGene: Mm.3929



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