在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse Tyrosine-protein phosphatase non-receptor type 12 (Ptpn12)

Recombinant Mouse Tyrosine-protein phosphatase non-receptor type 12 (Ptpn12)

  • 中文名稱：
    小鼠Ptpn12重組蛋白
  • 貨號：
    CSB-YP019026MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Ptpn12重組蛋白
  • 貨號：
    CSB-EP019026MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Ptpn12重組蛋白
  • 貨號：
    CSB-EP019026MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Ptpn12重組蛋白
  • 貨號：
    CSB-BP019026MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Ptpn12重組蛋白
  • 貨號：
    CSB-MP019026MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Ptpn12
  • Uniprot No.：
  • 別名：
    Ptpn12; Tyrosine-protein phosphatase non-receptor type 12; EC 3.1.3.48; MPTP-PEST; Protein-tyrosine phosphatase P19; P19-PTP
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full length protein
  • 表達(dá)區(qū)域：
    1-775
  • 氨基酸序列
    MEQVEILRRF IQRVQAMKSP DHNGEDNFAR DFMRLRRLST KYRTEKIYPT ATGEKEENVK KNRYKDILPF DHSRVKLTLK TPSQDSDYIN ANFIKGVYGP KAYVATQGPL ANTVIDFWRM IWEYNVVIIV MACREFEMGR KKCERYWPLY GEDPITFAPF KISCENEQAR TDYFIRTLLL EFQNESRRLY QFHYVNWPDH DVPSSFDSIL DMISLMRKYQ EHEDVPICIH CSAGCGRTGA ICAIDYTWNL LKAGKIPEEF NVFNLIQEMR TQRHSAVQTK EQYELVHRAI AQLFEKQLQL YEIHGAQKIA DGNEITTGTM VSSIDSEKQD SPPPKPPRTR SCLVEGDAKE EILQPPEPHP VPPILTPSPP SAFPTVTTVW QDSDRYHPKP VLHMASPEQH PADLNRSYDK SADPMGKSES AIEHIDKKLE RNLSFEIKKV PLQEGPKSFD GNTLLNRGHA IKIKSASSSV VDRTSKPQEL SAGALKVDDV SQNSCADCSA AHSHRAAESS EESQSNSHTP PRPDCLPLDK KGHVTWSLHG PENATPVPDS PDGKSPDNHS QTLKTVSSTP NSTAEEEAHD LTEHHNSSPL LKAPLSFTNP LHSDDSDSDG GSSDGAVTRN KTSISTASAT VSPASSAESA CTRRVLPMSI ARQEVAGTPH SGAEKDADVS EESPPPLPER TPESFVLADM PVRPEWHELP NQEWSEQRES EGLTTSGNEK HDAGGIHTEA SADSPPAFSD KKDQITKSPA EVTDIGFGNR CGKPKGPREP PSEWT
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Dephosphorylates a range of proteins, and thereby regulates cellular signaling cascades. Dephosphorylates cellular tyrosine kinases, such as ERBB2 and PTK2B/PYK2, and thereby regulates signaling via ERBB2 and PTK2B/PYK2. Selectively dephosphorylates ERBB2 phosphorylated at 'Tyr-1112', 'Tyr-1196', and/or 'Tyr-1248'.
  • 基因功能參考文獻(xiàn)：
    1. PTPN12-deficient, ErbB2-dependent breast cancer cells were more resistant to anoikis and had augmented migratory and invasive properties. PMID: 26391955
    2. Integrin beta 8 and PTP-PEST form protein complexes at the leading edge of migrating cells and balance patterns of Rac1 and Cdc42 signaling by controlling the subcellular localization and phosphorylation status of Rho GDP dissociation inhibitor 1. PMID: 25666508
    3. Pyk2 deregulation played a pivotal role in the migration defect caused by PTPN12 deficiency. PMID: 24366546
    4. Regulation of the Src kinase-associated phosphoprotein 55 homologue by the protein tyrosine phosphatase PTP-PEST in the control of cell motility. PMID: 23897807
    5. macrophage fusion is critically dependent on PTP-PEST. PMID: 23589331
    6. Overexpression of PTP-PEST substantially inhibits lipopolysaccharide (LPS)-induced tyrosine phosphorylation of IkappaB kinase (IKKbeta) at Tyr188/199 in RAW264.7 cells. PMID: 23296707
    7. PTP-PEST is a key regulator of integrin-mediated functions in endothelial cells. PMID: 23105101
    8. the paxillin-PTP-PEST interaction contributes to integrin signaling PMID: 16317044
    9. PTP-PEST plays an essential function in early embryogenesis. PMID: 17070019
    10. PTP-PEST actively contributes to the cellular apoptotic response and reveal the importance of caspases as regulators of PTPs in apoptosis. PMID: 17130234
    11. PTP-PEST tempers T cell activation by dephosphorylating T cell receptor (TCR)-proximal signaling molecules, such as Lck, and that down-regulation of PTP-PEST may be a reason for the increased response to TCR triggering of previously activated T cells. PMID: 18457880
    12. Results show a regulatory role for PTP-PEST on dephosphorylation of c-Src at Y527 and phosphorylation at Y418 in the catalytic site. PMID: 19350555
    13. Data show that ERK phosphorylates FAK S910 and recruits PIN1 and PTP-PEST, which colocalize with FAK at the lamellipodia of migrating cells. PMID: 19595712

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cytoplasm. Cell junction, focal adhesion. Cell projection, podosome.
  • 蛋白家族：
    Protein-tyrosine phosphatase family, Non-receptor class 4 subfamily
  • 數(shù)據(jù)庫鏈接：


主站蜘蛛池模板： 国产成人a人亚洲精品无码 | 国产精品久久人妻无码网站蜜臀| 亚洲色大成网站在线| 日韩精品亚洲色大成网站| 中国真实偷乱视频| 免费人妻av无码专区| 久久亚洲精品无码播放| 国产午睡沙发被弄醒完整版| 国产av午夜精品一区二区三区| 国产成人av无码精品| 男人的好看免费观看在线视频| 国产永久免费观看的黄网站| 亚洲精品在看在线观看高清| 51精品国产人成在线观看| 亚洲女女女同性video| 99久视频只有精品2019| 亚洲国产精久久久久久久| 日产一区日产2区| 国产在线精品一区二区在线看 | 国产黑色丝袜在线看片不卡顿| 中文在线8资源库| 又色又爽又高潮免费视频国产| 欧美变态另类牲交| 欧美性猛交xxxx黑人猛交| 国产情侣真实露脸在线| 亚洲国产av天码精品果冻传媒| 久久婷婷五月综合色俺也想去| 国产又黄又爽又色的免费视频| 国产在线观看码高清视频| 小说区亚洲综合第1页| 亚洲无线码免费| 国产亚洲视频中文字幕97精品| 夜夜躁狠狠躁日日躁孕妇| 末发育娇小性色xxxxx| 自拍偷自拍亚洲精品牛影院| 少妇人妻系列无码专区视频| 狠狠cao2020高清视频| 国内精品久久久久久久电影视 | 久久亚洲一区二区三区四区五区| 国产成人亚洲日韩欧美| 久久久国产精品人人片|