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  4. Recombinant Mouse Trichoplein keratin filament-binding protein (Tchp)

Recombinant Mouse Trichoplein keratin filament-binding protein (Tchp)

  • 中文名稱：
    小鼠Tchp重組蛋白
  • 貨號：
    CSB-YP663635MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Tchp重組蛋白
  • 貨號：
    CSB-EP663635MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Tchp重組蛋白
  • 貨號：
    CSB-EP663635MO-B
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Tchp重組蛋白
  • 貨號：
    CSB-BP663635MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Tchp重組蛋白
  • 貨號：
    CSB-MP663635MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Tchp
  • Uniprot No.：
  • 別名：
    Tchp; Trichoplein keratin filament-binding protein; Protein TCHP; Mitochondrial protein with oncostatic activity; Mitostatin
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達區(qū)域：
    1-497
  • 氨基酸序列
    MALPTLPSYW SSRKHMDLRQ RQHQQEDQFR QQWEQNSRYF RTWDIHNSKQ IEWSSKISYQ RSMHAYHCEK MKEEKRKILE LRRERLRELL LEEQDLLAAE LDELRLSMGL REQRLREQHQ DLKSAREEQR KLIAERLLYE HWKKNNPKLR ELELDLHKKH VINSWATQKE EKKQQEATEK QENKRLENQY AAARREAEAR MRVEEERRQL EGRLQAEALR QQMEELKQKE MEATKLKKEQ ENLLRQRWEL ERLEEERRQM AALRRKTELG RFLKHQYNAQ LNRRTQEIQE ELEVDGRILQ ALLEKEGELQ QVELARREQA RADAAWMKQV IEEQLQLEKA REAELQQLLR EEAKEMWEKR EAEWAREQVA RDRLMSEVLT GRQQQILEKI EQNRRAQEET LKHREKLIRS LEEGKQLAQR AKEESEELKL ARKQELEAQV AERQGQEWEA ARQEEEEEEE ARQAEEHSNA LLQQEAKTMA EKGYQPKLHG HLRIAWD
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Tumor suppressor which has the ability to inhibit cell growth and be pro-apoptotic during cell stress. May act as a 'capping' or 'branching' protein for keratin filaments in the cell periphery. May regulate K8/K18 filament and desmosome organization mainly at the apical or peripheral regions of simple epithelial cells. Is a negative regulator of ciliogenesis.
  • 基因功能參考文獻：
    1. Ndel1 acts as a novel upstream regulator of the trichoplein-Aurora A pathway to inhibit primary cilia assembly. PMID: 26880200
    2. MITOSTATIN may acts as a tumor suppressor gene in prostate cancer. PMID: 21573075
  • 亞細胞定位：
    Cytoplasm, cytoskeleton. Cytoplasm. Cell membrane. Mitochondrion.
  • 蛋白家族：
    TCHP family
  • 組織特異性：
    Expressed in all tissues examined, including brain, liver, small intestine, large intestine, lung and heart. Found concentrated in tubular structures within hepatocytes, and in the apical cortical region and desmosomes of the apical junctional domain in e
  • 數(shù)據(jù)庫鏈接：


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