在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Transforming growth factor beta activator LRRC33 (NRROS), partial

In Stock
  • 中文名稱:
    小鼠Nrros重組蛋白
  • 貨號:
    CSB-EP807383MO
  • 說明書:
  • 規格:
    ¥2328
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 基因名:
    Nrros
  • Uniprot No.:
  • 別名:
    Nrros; Lrrc33Transforming growth factor beta activator LRRC33; Leucine-rich repeat-containing protein 33; Negative regulator of reactive oxygen species
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Partial
  • 來源:
    E.coli
  • 分子量:
    73.2 kDa
  • 表達區域:
    29-651aa
  • 氨基酸序列
    ASQGGCKVVDGVADCRGLNLASVPSSLPPHSRMLILDANPLKDLWNHSLQAYPRLENLSLHSCHLDRISHYAFREQGHLRNLVLADNRLSENYKESAAALHTLLGLRRLDLSGNSLTEDMAALMLQNLSSLEVVSLARNTLMRLDDSIFEGLEHLVELDLQRNYIFEIEGGAFDGLTELRRLNLAYNNLPCIVDFSLTQLRFLNVSYNILEWFLAAREEVAFELEILDLSHNQLLFFPLLPQCGKLHTLLLQDNNMGFYRELYNTSSPQEMVAQFLLVDGNVTNITTVNLWEEFSSSDLSALRFLDMSQNQFRHLPDGFLKKTPSLSHLNLNQNCLKMLHIREHEPPGALTELDLSHNQLAELHLAPGLTGSLRNLRVFNLSSNQLLGVPTGLFDNASSITTIDMSHNQISLCPQMVPVDWEGPPSCVDFRNMGSLRSLSLDGCGLKALQDCPFQGTSLTHLDLSSNWGVLNGSISPLWAVAPTLQVLSLRDVGLGSGAAEMDFSAFGNLRALDLSGNSLTSFPKFKGSLALRTLDLRRNSLTALPQRVVSEQPLRGLQTIYLSQNPYDCCGVEGWGALQQHFKTVADLSMVTCNLSSKIVRVVELPEGLPQGCKWEQVDTGL
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 6xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Tris-based buffer,50% glycerol
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Key regulator of transforming growth factor beta-1 (TGFB1) specifically required for microglia function in the nervous system. Required for activation of latent TGF-beta-1 in macrophages and microglia: associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGFB1, and regulates integrin-dependent activation of TGF-beta-1. TGF-beta-1 activation mediated by LRRC33/NRROS is highly localized: there is little spreading of TGF-beta-1 activated from one microglial cell to neighboring microglia, suggesting the existence of localized and selective activation of TGF-beta-1 by LRRC33/NRROS. Indirectly plays a role in Toll-like receptor (TLR) signaling: ability to inhibit TLR-mediated NF-kappa-B activation and cytokine production is probably a consequence of its role in TGF-beta-1 signaling (Probable).
  • 基因功能參考文獻:
    1. NRROS-deficient (Nrros(-/-)) mice show defects in motor functions and die before 6 months of age. Nrros(-/-) mice display astrogliosis and lack normal CD11b(hi)CD45(lo) microglia, but they show no detectable demyelination or neuronal loss. perivascular macrophage-like myeloid cells populate the Nrros(-/-) CNS. Cx3cr1-driven deletion of Nrros shows its crucial role in microglial establishment during early embryonic stages. PMID: 28459434
    2. this study presents NRROS as a novel negative regulator of RANKL-induced osteoclastogenesis. PMID: 26442864
    3. results suggest that LRRC33 and TLRs may form a negative-feedback loop, which is important for the maintenance of immune homeostasis. PMID: 24550525
    4. NRROS provides a hitherto undefined mechanism for regulating ROS production--one that enables phagocytes to produce higher amounts of ROS, if required to control invading pathogens, while minimizing unwanted collateral tissue damage PMID: 24739962
  • 亞細胞定位:
    Cell membrane; Single-pass type I membrane protein. Endoplasmic reticulum membrane; Single-pass type I membrane protein.
  • 組織特異性:
    Mainly expressed in cells of hematopoietic origin, such as in immune organs such as lymph nodes, thymus and spleen. Among leukocytes, expressed at higher level in myeloid cell such as macrophages, neutrophils and dendritic cells. Highly expressed in centr
  • 數據庫鏈接:


主站蜘蛛池模板: 欧美三级韩国三级日本三斤| 亚洲国产一区二区精品无码| 亚洲日本乱码一区二区产线一∨| 国产精品系列无码专区| 国产无人区码一码二码三mba | 久久精品免费国产大片| 日韩av第一页在线播放| 久久婷婷五月综合国产尤物app| 国产精品国产高清国产av | 亚洲色欲久久久久综合网| 高潮喷吹一区二区在线观看| 天堂在线www资源在线| 男女啪啪网站大全免费 | 国产亚洲日韩在线a不卡| 精品亚洲成a人无码成a在线观看 | 国产乱码精品一区二区三区四川人| 欧美老人巨大xxxx做受| 波多野结衣网站| 亚洲最大av一区二区三区| 亚洲国产精品无码久久秋霞| 老色69久久九九精品高潮| 日本一本二本三区免费 | 亚洲欧美色一区二区三区| 中出あ人妻熟女中文字幕| 乌克兰性欧美精品高清| 国产一卡二卡三卡四卡视频版| 久久久久九九精品影院| 无码人妻精品一区二 | 亚洲国产欧美在线成人app| 成人做爰视频www| 女人下边被添全过视频的网址| 亚洲乱码一区二三四区ava| 国产精品国产午夜免费看福利| 久久精品国产2020| 亚洲精品久久久久久久久久久| 欧美zozo另类特级| 久久九九精品国产免费看小说| 国产亚洲精品成人aa片| 久久这里只精品国产免费10| 亚洲性人人天天夜夜摸| 18禁成年无码免费网站|